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Amiloride for Arterial Stiffness in Obesity
Study Summary
This trial will test whether the ENaC inhibitor amiloride can improve endothelial function and arterial stiffness in obese, insulin resistant subjects. The trial will involve pre and postmenopausal women and age-matched men.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2017 Phase 1 trial • 42 Patients • NCT03031496Trial Design
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Who is running the clinical trial?
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- You currently smoke or use tobacco.I regularly take NSAIDs for pain or inflammation.I am not pregnant, breastfeeding, or if I am a woman capable of becoming pregnant, I am using contraception.I have a history of diabetes (type 1 or 2).My blood pressure is not well-controlled.I haven't had a heart attack, stroke, or heart surgery in the last year.Your potassium level is higher than 5.0 mqE/L when tested.I am between 30 and 70 years old.Your blood pressure is lower than 110/70.I do not have uncontrolled thyroid, severe liver disease, or severely reduced kidney function.Your body mass index (BMI) is between 25.1 and 50, or your waist size is over 88 cm (35 inches) if you're a woman, or over 102 cm (40 inches) if you're a man.You have high triglycerides, low "good" cholesterol, high blood pressure, or high blood sugar levels.I have active cancer, not including basal cell or early-stage squamous cell skin cancer.You exercise regularly for more than 3 days a week at a medium or high level of effort.You drink more than 14 drinks per week if you are a man, or more than 7 drinks per week if you are a woman.I am taking medication or supplements that affect my potassium levels.
- Group 1: Amiloride
- Group 2: Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Does scientific literature support the use of Amiloride Pill?
"There are a total of 8 clinical trials currently underway for Amiloride Pill. 2 of those trials have advanced to Phase 3. Although most of the research is based in Birmingham and Cambridgeshire, there are 20 different locations running these tests."
Are there any remaining vacancies for participants in this clinical trial?
"This trial, as listed on clinicaltrials.gov, is actively recruiting participants. It was first posted on July 15th, 2019 and was last updated on May 19th, 2022."
Would elderly patients be able to participate in this research?
"The age range for participants in this trial are individuals that are over 30 and below 70 years old."
How many people are volunteering to participate in this experiment?
"Yes, the research team is currently looking for volunteers to participate in this study. According to the information available on clinicaltrials.gov, the trial was first posted on 7/15/2019 and has since been edited on 5/19/2022. So far, 157 people have signed up at the single location where this study is taking place."
What are some conditions that Amiloride Pill is known to improve?
"Amiloride Pills are most often used to lower blood pressure in patients with hypertensive disease. However, this medication can also be given to those suffering from nephrolithiasis, congestive heart failure (chf), and polyuria."
Could I possibly take part in this research?
"This clinical trial is currently enrolling 157 patients that suffer from insulin resistance and are between 30-70 years old. The most important criteria for applicants are as follows: being aged 30 to 70 years old at randomization, having a Body mass index (BMI) of 25.1-50 kg/m2 or waist circumference > 88 cm (> 35 in) if you are a woman and >102 cm (>40 in) if you are a man."
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