Faslodex

Breast, Malignant Neoplasms, PI3K Gene Mutation + 4 more

Treatment

8 FDA approvals

1 Active Study for Faslodex

Treatment for

Breast

What is Faslodex

Fulvestrant

The Generic name of this drug

Treatment Summary

Fulvestrant is a medication used to treat metastatic breast cancer in postmenopausal women whose cancer has progressed even after taking anti-estrogen therapy. It works by blocking the estrogen receptors in the body and reducing their levels. It is usually prescribed as a single drug, but can also be used in combination with alpelisib for certain types of breast cancer.

Faslodex

is the brand name

image of different drug pills on a surface

Faslodex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Faslodex

Fulvestrant

2010

Approved as Treatment by the FDA

Fulvestrant, commonly known as Faslodex, is approved by the FDA for 8 uses which include Progression, Disease and Advanced or Metastatic Breast Cancer .

Progression, Disease

Used to treat Progression, Disease in combination with Abemaciclib

Advanced or Metastatic Breast Cancer

Used to treat Advanced or Metastatic Breast Cancer in combination with Abemaciclib

PI3K Gene Mutation

Used to treat PI3K Gene Mutation in combination with Alpelisib

Disease

Used to treat disease progression after endocrine based therapy in combination with Alpelisib

PIK3CA Gene Mutation

Used to treat PIK3CA Gene Mutation in combination with Alpelisib

Malignant Neoplasms

Used to treat Advanced or Metastatic Breast Cancer in combination with Abemaciclib

Disease Progression

Used to treat Progression, Disease in combination with Abemaciclib

prior endocrine therapy

Used to treat prior endocrine therapy in combination with Abemaciclib

Effectiveness

How Faslodex Affects Patients

Fulvestrant is a drug that is injected directly into the muscle and works by blocking the effects of estrogen in the body. It does not have any estrogen-like effects itself.

How Faslodex works in the body

Fulvestrant works by stopping estrogen from attaching to cancer cells. It does this by attaching to the cells instead of estrogen, blocking the hormone from binding. It also breaks down the cells' estrogen receptors so they can no longer bind to the hormone. This prevents the growth of both tamoxifen-resistant and estrogen-sensitive breast cancer cells.

When to interrupt dosage

The measure of Faslodex relies upon the recognized affliction, including Progression, Disease, Breast and PIK3CA Gene Mutation. The quantity of dosage differs, as specified by the technique of delivery (e.g. Solution or Injection) featured in the table beneath.

Condition

Dosage

Administration

Breast

, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg

Solution - Intramuscular, Solution, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection - Intramuscular, Injection

PIK3CA Gene Mutation

, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg

Solution - Intramuscular, Solution, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection - Intramuscular, Injection

Malignant Neoplasms

, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg

Solution - Intramuscular, Solution, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection - Intramuscular, Injection

PI3K Gene Mutation

, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg

Solution - Intramuscular, Solution, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection - Intramuscular, Injection

Disease Progression

, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg

Solution - Intramuscular, Solution, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection - Intramuscular, Injection

Disease

, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg

Solution - Intramuscular, Solution, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection - Intramuscular, Injection

prior endocrine therapy

, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg

Solution - Intramuscular, Solution, , Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection - Intramuscular, Injection

Warnings

There are 2 known major drug interactions with Faslodex.

Common Faslodex Drug Interactions

Drug Name

Risk Level

Description

Ospemifene

Major

The risk or severity of adverse effects can be increased when Fulvestrant is combined with Ospemifene.

Fluoroestradiol F-18

Moderate

Fulvestrant may decrease effectiveness of Fluoroestradiol F-18 as a diagnostic agent.

Faslodex Toxicity & Overdose Risk

There has not been a case of overdosage in humans.

image of a doctor in a lab doing drug, clinical research

Faslodex Novel Uses: Which Conditions Have a Clinical Trial Featuring Faslodex?

There are 20 active investigations examining the potential of Faslodex to inhibit Progression of Disease, Breast Malignancies and Neoplasms.

Condition

Clinical Trials

Trial Phases

Breast

0 Actively Recruiting

Malignant Neoplasms

0 Actively Recruiting

Disease

0 Actively Recruiting

PIK3CA Gene Mutation

0 Actively Recruiting

Disease Progression

0 Actively Recruiting

PI3K Gene Mutation

1 Actively Recruiting

Phase 1

prior endocrine therapy

0 Actively Recruiting

Faslodex Reviews: What are patients saying about Faslodex?

Patient Review

4/4/2014

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

I've been using Faslodex for almost a year now and I'm really happy with it. The initial side effects were a bit much, but they lessened after each dose. Now the only issue I have is some soreness at the injection site, but even that goes away if I walk around on the day of treatment. My markers are almost normal now too, which is great. I'm enjoying everyday activities again and feeling good!

Patient Review

10/27/2016

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

I started this treatment on 4/20/15. My tumor markers decreased sharply at first, but have since gone up slightly and have now steadied for the last 4 months, which is encouraging. I've had bouts of nausea and times when I am too tired to move, but these pass and the good times outweigh the bad. I remain active, walking the beach in morning and horseback riding on weekends. I have excellent nurses and have had no ill effects from the injections themselves or issues with the injection sites.

Patient Review

6/5/2015

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

My diagnosis is stage four, but since I started receiving these injections twice a month (Faslodex + Xgeva), I haven't experienced any pain whatsoever - not even at the injection site!

Patient Review

6/3/2014

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

After just six doses of this medication, my stage-three tumor has shrunk significantly. I've been getting 500mg each month and have had no issues other than the occasional pain at the injection site.

4.7

Patient Review

7/16/2014

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

I was originally diagnosed with breast cancer in 2005 and it came back in 2012. I started receiving shots about a year ago and all tumors have been shrinking since then. The shots need to be warmed up beforehand or the pain will last for two weeks. My doctor and nurse are very good at making me comfortable during the process. Shots are not fun, but they're working so I can't complain too much. I have CAT scans every four months

4.7

Patient Review

1/19/2016

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

I've been on this medication for about two years now. The hot flashes are really bad—I wake up drenched in sweat most mornings. I also have issues with fatigue and pain at the injection site, as well as headaches. The symptoms vary from month to month, and I haven't been able to figure out any sort of pattern. Thankfully, though, the cancer hasn't spread elsewhere.

4.7

Patient Review

12/1/2021

Faslodex for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

I've been getting Faslodex injections for a year now, and my oncologist says everything is going well. I get two injections per month; they hurt where they stick you, but using a heating pad seems to help quite a bit. The only other downside is that my urine smells bad for three days after the injection, but I much prefer this method of treatment to the pills I was taking before.

4.3

Patient Review

2/16/2015

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

To reduce injection site pain, I take 2 ibuprofen an hour or more before the shots, AND immediately before the injection, I take one dose of the homeopathic remedy arnica montana 30C. This has been really effective for me in reducing pain around the injection site.

3.7

Patient Review

10/16/2019

Faslodex for malignant tumor or cancer

For a little over a week after this injection, I could smell something burning. It was quite intense and made the pain I was already feeling much worse.

3.3

Patient Review

5/31/2021

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

Faslodex has some pretty gnarly side effects, like making your pee stink to high heaven for at least a week post-treatment. Additionally, it dried me out something fierce. And I don't just mean externally, but also vaginal dryness, dry eyes, and an incrediblydry scalp. Right now my sinuses are so bad I have a headache, drippy nose, andsinus pain.

2.7

Patient Review

12/30/2019

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

It has kept me NED for going on 6 yrs now. Bad things are that if you have a bad back, it will aggravate it. More frequent UTI's and bad fatique. It also causes painful scar tissue.

1.7

Patient Review

6/24/2015

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

Has anyone taken Vaslodex while travelling overseas? I have a layover that will last more than six hours and am wondering if this is safe.

1.7

Patient Review

10/6/2018

Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy

Unfortunately, this drug did not work for me. My tumor doubled in size while taking it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about faslodex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Faslodex chemotherapy?

"Faslodex is a type of hormone therapy, not a chemotherapy drug or an aromatase inhibitor. Chemotherapy works by killing the cells in your body that multiply quickly."

Answered by AI

What is the drug Faslodex used for?

"Faslodex is a drug used to treat advanced-stage breast cancer that is positive for hormone receptors and negative for HER2. It works by downregulating estrogen receptors. It can be used alone or in combination with other targeted therapies."

Answered by AI

What are side effects of Faslodex?

"The side effects of the medication include pain at the injection site, headache, pain in the muscles, joints, or bones, back pain, pain in the hands, feet, arms, or legs, hot flashes, nausea and vomiting, and loss of appetite."

Answered by AI

Is Faslodex chemotherapy or immunotherapy?

"Faslodex is primarily used as a hormonal therapy to limit the amount of estrogen in the body, which may help to treat breast cancer. It is sometimes used in combination with other medications."

Answered by AI