Faslodex

Breast, Malignant Neoplasms, PI3K Gene Mutation + 4 more
Treatment
8 FDA approvals
1 Active Study for Faslodex

What is Faslodex

FulvestrantThe Generic name of this drug
Treatment SummaryFulvestrant is a medication used to treat metastatic breast cancer in postmenopausal women whose cancer has progressed even after taking anti-estrogen therapy. It works by blocking the estrogen receptors in the body and reducing their levels. It is usually prescribed as a single drug, but can also be used in combination with alpelisib for certain types of breast cancer.
Faslodexis the brand name
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Faslodex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Faslodex
Fulvestrant
2010
29

Approved as Treatment by the FDA

Fulvestrant, commonly known as Faslodex, is approved by the FDA for 8 uses which include Progression, Disease and Advanced or Metastatic Breast Cancer .
Progression, Disease
Used to treat Progression, Disease in combination with Abemaciclib
Advanced or Metastatic Breast Cancer
Used to treat Advanced or Metastatic Breast Cancer in combination with Abemaciclib
PI3K Gene Mutation
Used to treat PI3K Gene Mutation in combination with Alpelisib
Disease
Used to treat disease progression after endocrine based therapy in combination with Alpelisib
PIK3CA Gene Mutation
Used to treat PIK3CA Gene Mutation in combination with Alpelisib
Malignant Neoplasms
Used to treat Advanced or Metastatic Breast Cancer in combination with Abemaciclib
Disease Progression
Used to treat Progression, Disease in combination with Abemaciclib
prior endocrine therapy
Used to treat prior endocrine therapy in combination with Abemaciclib

Effectiveness

How Faslodex Affects PatientsFulvestrant is a drug that is injected directly into the muscle and works by blocking the effects of estrogen in the body. It does not have any estrogen-like effects itself.
How Faslodex works in the bodyFulvestrant works by stopping estrogen from attaching to cancer cells. It does this by attaching to the cells instead of estrogen, blocking the hormone from binding. It also breaks down the cells' estrogen receptors so they can no longer bind to the hormone. This prevents the growth of both tamoxifen-resistant and estrogen-sensitive breast cancer cells.

When to interrupt dosage

The measure of Faslodex relies upon the recognized affliction, including Progression, Disease, Breast and PIK3CA Gene Mutation. The quantity of dosage differs, as specified by the technique of delivery (e.g. Solution or Injection) featured in the table beneath.
Condition
Dosage
Administration
Breast
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
PIK3CA Gene Mutation
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Malignant Neoplasms
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
PI3K Gene Mutation
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Disease Progression
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
Disease
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular
prior endocrine therapy
, 250.0 mg/mL, 50.0 mg/mL, 250.0 mg
, Intramuscular, Solution, Solution - Intramuscular, Injection, solution, Injection, solution - Intramuscular, Injection, Injection - Intramuscular

Warnings

There are 2 known major drug interactions with Faslodex.
Common Faslodex Drug Interactions
Drug Name
Risk Level
Description
Ospemifene
Major
The risk or severity of adverse effects can be increased when Fulvestrant is combined with Ospemifene.
Fluoroestradiol F-18
Moderate
Fulvestrant may decrease effectiveness of Fluoroestradiol F-18 as a diagnostic agent.
Faslodex Toxicity & Overdose RiskThere has not been a case of overdosage in humans.
image of a doctor in a lab doing drug, clinical research

Faslodex Novel Uses: Which Conditions Have a Clinical Trial Featuring Faslodex?

There are 20 active investigations examining the potential of Faslodex to inhibit Progression of Disease, Breast Malignancies and Neoplasms.
Condition
Clinical Trials
Trial Phases
Breast
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Disease
0 Actively Recruiting
PIK3CA Gene Mutation
0 Actively Recruiting
Disease Progression
0 Actively Recruiting
PI3K Gene Mutation
1 Actively Recruiting
Phase 2
prior endocrine therapy
0 Actively Recruiting

Faslodex Reviews: What are patients saying about Faslodex?

5Patient Review
4/4/2014
Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy
I've been using Faslodex for almost a year now and I'm really happy with it. The initial side effects were a bit much, but they lessened after each dose. Now the only issue I have is some soreness at the injection site, but even that goes away if I walk around on the day of treatment. My markers are almost normal now too, which is great. I'm enjoying everyday activities again and feeling good!
5Patient Review
10/27/2016
Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy
I started this treatment on 4/20/15. My tumor markers decreased sharply at first, but have since gone up slightly and have now steadied for the last 4 months, which is encouraging. I've had bouts of nausea and times when I am too tired to move, but these pass and the good times outweigh the bad. I remain active, walking the beach in morning and horseback riding on weekends. I have excellent nurses and have had no ill effects from the injections themselves or issues with the injection sites.
5Patient Review
6/5/2015
Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy
My diagnosis is stage four, but since I started receiving these injections twice a month (Faslodex + Xgeva), I haven't experienced any pain whatsoever - not even at the injection site!
5Patient Review
6/3/2014
Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy
After just six doses of this medication, my stage-three tumor has shrunk significantly. I've been getting 500mg each month and have had no issues other than the occasional pain at the injection site.
4.7Patient Review
7/16/2014
Faslodex for Metastatic Breast Cancer Progression Post-Antiestrogen Therapy
I was originally diagnosed with breast cancer in 2005 and it came back in 2012. I started receiving shots about a year ago and all tumors have been shrinking since then. The shots need to be warmed up beforehand or the pain will last for two weeks. My doctor and nurse are very good at making me comfortable during the process. Shots are not fun, but they're working so I can't complain too much. I have CAT scans every four months
View All Reviews
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Patient Q&A Section about faslodex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Faslodex chemotherapy?

"Faslodex is a type of hormone therapy, not a chemotherapy drug or an aromatase inhibitor. Chemotherapy works by killing the cells in your body that multiply quickly."

Answered by AI

What is the drug Faslodex used for?

"Faslodex is a drug used to treat advanced-stage breast cancer that is positive for hormone receptors and negative for HER2. It works by downregulating estrogen receptors. It can be used alone or in combination with other targeted therapies."

Answered by AI

What are side effects of Faslodex?

"The side effects of the medication include pain at the injection site, headache, pain in the muscles, joints, or bones, back pain, pain in the hands, feet, arms, or legs, hot flashes, nausea and vomiting, and loss of appetite."

Answered by AI

Is Faslodex chemotherapy or immunotherapy?

"Faslodex is primarily used as a hormonal therapy to limit the amount of estrogen in the body, which may help to treat breast cancer. It is sometimes used in combination with other medications."

Answered by AI

Clinical Trials for Faslodex

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