<p>Budesonide is a medication used to help get active, mild to moderate <a href="https://www.withpower.com/clinical-trials/ulcerative-colitis">ulcerative colitis</a> under control.</p>

Uceris

Proteinuria, Asthma, Itching + 16 more

Treatment

20 Active Studies for Uceris

Treatment for

Proteinuria

What is Uceris

Budesonide

The Generic name of this drug

Treatment Summary

Budesonide is a type of steroid used to treat inflammation of the lungs and intestines. It is used to treat asthma, COPD, Crohn's disease, and ulcerative colitis. Budesonide was approved by the FDA in 1994 and is sold under brand names such as Pulmicort and Entocort.

Rhinocort

is the brand name

image of different drug pills on a surface

Uceris Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Rhinocort

Budesonide

1994

134

Effectiveness

How Uceris Affects Patients

Budesonide is a medication used to decrease inflammation in the respiratory and digestive systems. The amount of budesonide taken can vary greatly between patients and it is known to be a relatively safe drug. However, patients should be aware of the risk of increased cortisol levels in the body and suppressed adrenal glands when taking this drug.

How Uceris works in the body

Corticosteroids reduce inflammation by stopping blood vessels from widening and white blood cells from moving to the inflamed area. They also change how genes are expressed, which affects how cells behave. Corticosteroids reduce the body's ability to create inflammation-causing molecules and increase the production of anti-inflammatory molecules. At lower doses, corticosteroids reduce inflammation, and at higher doses, they suppress the immune system. When taken for a long time, corticosteroids can also raise sodium levels and lower potassium levels in the body.

When to interrupt dosage

The quantity of Uceris is contingent upon the diagnosed condition, including Vasomotor Rhinitis, Crohn's Disease and Chronic Obstructive Pulmonary Disease (COPD). The amount of dosage varies, as per the administration technique (e.g. Enema; Kit; Tablet - Rectal or Respiratory (inhalation)) detailed in the below table.

Condition

Dosage

Administration

Crohn Disease

, 0.25 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 0.09 mg, 0.032 mg, 3.0 mg, 0.18 mg, 0.2 mg, 0.5 mg, 9.0 mg, 28.0 mg, 2.3 mg, 0.08 mg, 0.16 mg, 0.00008 mg/hour, 0.32 mg, 1.0 mg, 6.0 mg, 0.125 mg/mL, 4.0 mg, 0.064 mg/pump actuation, 0.4 mg/pump actuation, 0.1 mg/pump actuation, 2.0 mg/pump actuation, 0.2 mg/pump actuation, 0.182 mg/pump actuation

Respiratory (inhalation), Inhalant, , Inhalant - Respiratory (inhalation), Suspension, Suspension - Respiratory (inhalation), Aerosol, powder, Aerosol, powder - Respiratory (inhalation), Spray, metered, Nasal, Spray, metered - Nasal, Powder - Respiratory (inhalation), Powder, Aerosol, foam, Aerosol, foam - Rectal, Rectal, Capsule, delayed release pellets - Oral, Capsule, delayed release pellets, Tablet, extended release, Tablet, extended release - Oral, Enema; Kit; Tablet, Enema; Kit; Tablet - Rectal, Capsule, extended release - Oral, Capsule, extended release, Capsule, coated pellets - Oral, Nasal; Respiratory (inhalation), Aerosol - Respiratory (inhalation), Aerosol, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Oral, Inhalant - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Powder, metered, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Capsule - Oral, Capsule, Cutaneous, Aerosol, metered, Aerosol, metered - Respiratory (inhalation), Kit, Powder, metered - Respiratory (inhalation), Powder - Nasal; Respiratory (inhalation), Aerosol, metered - Nasal, Capsule, coated pellets, Kit - Rectal, Capsule, delayed release - Oral, Capsule, delayed release, Patch - Cutaneous, Patch

Colitis, Collagenous

Proteinuria

Nasal Congestion

Asthma

Itching

Skin Diseases

Acute Coryza

Ulcerative Colitis

Rhinitis, Vasomotor

Nasal Polyps

Crohn's Disease

Eosinophilic Esophagitis

Hypersensitivity

IGA Glomerulonephritis

Sinusitis

Crohn Disease

maintenance therapy

Chronic Obstructive Pulmonary Disease

Warnings

Uceris Contraindications

Condition

Risk Level

Notes

Asthma

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

Status Asthmaticus

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Budesonide may interact with Pulse Frequency

Severe Hypersensitivity Reactions

Do Not Combine

Budesonide may interact with Pulse Frequency

There are 20 known major drug interactions with Uceris.

Common Uceris Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Budesonide.

Abetimus

Major

The risk or severity of adverse effects can be increased when Budesonide is combined with Abetimus.

Uceris Toxicity & Overdose Risk

Acute overdose of corticosteroids is not common, however taking too much for too long can lead to an overproduction of corticosteroids and damage to the adrenal glands. In the case of overdose, the amount of corticosteroids taken should be reduced. A 200mg oral dose is deadly for female mice, and 400mg for male mice.

Uceris Novel Uses: Which Conditions Have a Clinical Trial Featuring Uceris?

516 active studies are presently examining the potential of Uceris to combat Chronic Obstructive Pulmonary Disease (COPD), Ulcerative Colitis and Allergic Reactions.

Condition

Clinical Trials

Trial Phases

Asthma

87 Actively Recruiting

Phase 1, Phase 4, Early Phase 1, Not Applicable, Phase 2, Phase 3

Itching

3 Actively Recruiting

Phase 3, Not Applicable

Chronic Obstructive Pulmonary Disease

72 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4

Proteinuria

5 Actively Recruiting

Phase 2, Phase 3, Phase 4, Phase 1

IGA Glomerulonephritis

0 Actively Recruiting

Ulcerative Colitis

17 Actively Recruiting

Phase 3, Phase 2, Phase 1, Not Applicable, Phase 4

Sinusitis

0 Actively Recruiting

Crohn's Disease

53 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1

Hypersensitivity

1 Actively Recruiting

Phase 4

Colitis, Collagenous

0 Actively Recruiting

Skin Diseases

0 Actively Recruiting

maintenance therapy

0 Actively Recruiting

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Eosinophilic Esophagitis

0 Actively Recruiting

Acute Coryza

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

Nasal Polyps

0 Actively Recruiting

Crohn Disease

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Uceris Reviews: What are patients saying about Uceris?

Patient Review

7/1/2014

Uceris for Ulcerated Colon

I was on Balsalaszide and it wasn't helping me, so my doctor put me on Uceris. The results were amazing! I went from four bloody diarrhea stools to just one within a day, and now my stools are pretty normal. I'm very happy with this treatment.

Patient Review

6/11/2018

Uceris for Ulcerated Colon

After a few weeks, my face became puffy and I had an increased heart rate.

4.3

Patient Review

8/19/2014

Uceris for Ulcerated Colon

Overall, this treatment has been great for my colitis. I'm glad that insurance covers it because it's really expensive. The constant urination is a bit annoying, but it's better than going to the bathroom every time I eat something.

Patient Review

11/24/2013

Uceris for Ulcerated Colon

Patient Review

5/16/2014

Uceris for Ulcerated Colon

This has been a literal life-saver for my son who was diagnosed with Refractory Celiac Disease and Lymphocitic Colitis. Many other medications have failed where this one succeeded in reducing pain, frequency of bathroom trips, and ultimately allowed him to return to school!

1.7

Patient Review

4/21/2016

Uceris for Ulcerated Colon

Uceris did not help me manage my colitis flare-up as advertised. If anything, it made the symptoms worse. I stopped taking it as soon as possible and Prednisone provided relief almost immediately.

Patient Review

7/10/2018

Uceris for Ulcerated Colon

I had a lot of negative side effects from this medication, including pain, loss of appetite, and more trips to the bathroom with blood in my stool. I'm glad it works for some people, but it definitely wasn't the right fit for me.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about uceris

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Uceris weaken your immune system?

"If you take UCERIS tablets, it may weaken your immune system. This means that you are more likely to get infections. To avoid getting sick, stay away from people who have contagious diseases like chickenpox or measles."

Answered by AI

Is Uceris a steroid?

"Budesonide is a medication used to help get active, mild to moderate ulcerative colitis under control."

Answered by AI

What are the side effects of Uceris?

"The following are some possible side effects: headache, dizziness, indigestion, nausea, vomiting, stomach pain, bloating, gas, constipation, feeling tired, back pain, joint pain, painful urination, cold symptoms such as stuffy nose, sneezing, sore throat, or pain anywhere in your body."

Answered by AI

How long does it take for Uceris to work?

"The second, more bothersome side effect, was fatigue.

It took about two weeks for the medication to take effect and my diarrhea to stop completely. I had two side effects: swelling in both ankles that lasted for a few days, and fatigue, which was more bothersome."

Answered by AI