64 Participants Needed

Cognitive Remediation for PTSD

PB
Overseen ByPascale Brillon Principal Investigator, Ph.D.

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests whether computer-based brain training, known as Cognitive Remediation Training, can help people with PTSD improve thinking skills and quality of life. Participants will either engage in specialized brain exercises or play regular computer games, both accompanied by group discussions about life quality. The study aims to determine if brain training can enhance memory, attention, and problem-solving more effectively than regular games. Suitable candidates for this trial are adults in Canada who have PTSD, speak French, have access to a computer with a camera, and can commit to the entire 8-week program. As an unphased trial, this study offers a unique opportunity to explore innovative treatments for PTSD and contribute to groundbreaking research.

Will I have to stop taking my current medications?

The trial requires that participants do not regularly use medications that affect brain function, like benzodiazepines (a type of medication often used for anxiety). If you are taking such medications, you may need to stop or adjust them to participate.

What prior data suggests that this cognitive remediation training is safe for individuals with PTSD?

Research has shown that cognitive remediation training, often used for PTSD, is generally well-received by participants. In past studies with similar computer-based brain exercises, no major negative effects were reported. These activities, which aim to boost memory, attention, and thinking skills, are usually safe for most people.

This approach has been tested in various settings and has shown positive results without major safety issues. Since this treatment doesn't involve surgery or injections and resembles playing computer games, it carries a low risk of side effects. Participants usually find these activities easy to do, and any discomfort, such as eye strain or tiredness from screen time, is typically mild and temporary.

Overall, evidence suggests that cognitive remediation training is a safe choice for those wanting to improve thinking skills and manage PTSD symptoms. However, discussing any concerns with a healthcare provider before starting the program is important.12345

Why are researchers excited about this trial?

Researchers are excited about Cognitive Remediation Training for PTSD because it offers a fresh approach by targeting cognitive functions directly. Unlike traditional therapies like cognitive behavioral therapy or medications that primarily address symptoms and emotional regulation, this method focuses on improving specific cognitive skills such as attention, memory, and problem-solving. By enhancing these cognitive abilities, the treatment aims to indirectly alleviate PTSD symptoms, potentially offering a novel pathway to recovery for individuals who may not fully benefit from existing treatments.

What evidence suggests that cognitive remediation training is effective for PTSD?

Research has shown that brain training exercises can improve memory and attention in people with PTSD. In this trial, participants will receive Cognitive Remediation Training, designed to address the thinking difficulties often seen in PTSD, thereby easing everyday tasks. A previous study found that a similar program, Goal Management Training (GMT), helped participants focus better and solve problems more effectively. These improvements suggest that this type of brain training might also aid in overall PTSD recovery.23456

Are You a Good Fit for This Trial?

This trial is for adults aged 18-45 living in Canada with a confirmed PTSD diagnosis, who speak and read French fluently. They must have computer access with a camera, secure internet, and private space for sessions. Participants need to be available for the full 8-week treatment protocol.

Inclusion Criteria

I have a computer with a camera and secure internet.
I have a private space for sessions.
I live in Canada.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in an 8-week program with weekly online sessions and at-home exercises

8 weeks
8 online sessions, 8 at-home exercises

Follow-up

Participants are monitored for safety and effectiveness after treatment

12 weeks
1 comprehensive assessment session

What Are the Treatments Tested in This Trial?

Interventions

  • Cognitive Remediation Training

Trial Overview

The study tests if specialized brain training can improve PTSD symptoms more effectively than regular computer games. It examines cognitive functions like memory and attention, quality of life, and daily functioning over an 8-week program with assessments before, after, and at 3 months.

How Is the Trial Designed?

2

Treatment groups

Experimental Treatment

Placebo Group

Group I: Cognitive Remediation TrainingExperimental Treatment1 Intervention
Group II: Video Games with Life Quality SupportPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Université du Québec a Montréal

Lead Sponsor

Trials
28
Recruited
5,600+

Citations

An Open-Label Feasibility Trial Examining the ...

The current study investigated the efficacy of an established cognitive remediation program, Goal Management Training (GMT), in improving cognitive functioning.

Psychosocial Factors and Efficacy of Remote Cognitive ...

The goal of this clinical trial is to evaluate whether computer-based brain training can help adults with post-traumatic stress disorder ...

Effectiveness of Cognitive Processing Therapy for PTSD in ...

This study provides promising data on the outcomes associated with a modified CPT protocol for treating PTSD in a high need but under-treated SMI population.

The effectiveness of cognitive processing therapy for ...

001, d = 2.91. Sustained improvements in PTSD symptoms were noted at the 3-month follow-up assessment. Psychosocial functioning notably improved ...

Cognitive Processing Therapy for PTSD

To date, CPT has been shown to improve common comorbid symptoms and clinical correlates of PTSD such as depression (12,33), suicidal ideation (34), health- ...

Long-Term Outcomes of Cognitive–Behavioral Treatments ...

CPT and PE resulted in lasting changes in PTSD and related symptoms over an extended period of time for female rape victims with extensive histories of trauma.