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What is Forteo
TeriparatideThe Generic name of this drug
Treatment SummaryTeriparatide is a medication manufactured by Eli Lilly and Company that is used to strengthen bones in patients with osteoporosis. It is a form of recombinant human parathyroid hormone, which helps to stimulate bone growth.
Forteois the brand name
Forteo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Forteo
Teriparatide
2002
4
Approved as Treatment by the FDA
Teriparatide, otherwise called Forteo, is approved by the FDA for 4 uses which include Osteoporosis caused by glucocorticoid and Low Testosterone .Osteoporosis caused by glucocorticoid
Helps manage Osteoporosis caused by glucocorticoid
Low Testosterone
Helps manage Hypogonadism
Osteoporosis
Helps manage Primary Osteoporosis
Osteoporosis
Helps manage Osteoporosis
Effectiveness
How Forteo Affects PatientsTeriparatide is a synthetic hormone that helps to create new bone in men and women. It increases the amount of bone in your body, increases markers of bone growth, and makes your bones stronger. Taking teriparatide also temporarily increases the amount of calcium in your blood and increases the amount of calcium your body gets rid of in your urine. It can also cause your body to get rid of more phosphorus, which can lead to a drop in phosphorus levels in your blood.
How Forteo works in the bodyParathyroid hormone (PTH) is a hormone that helps to regulate calcium and phosphate levels in the body. Excess PTH can break down bones. Teriparatide is a synthetic form of PTH that works differently from regular PTH. It stimulates new bone growth, rather than breaking down existing bones. It does this by binding to PTH type 1 receptors, which are found on osteoblasts, osteocytes, and kidney cells. This binding triggers pathways in the body that stimulate bone growth and reduce bone breakdown. It also increases the expression of certain proteins that help promote bone growth and decrease proteins that inhibit bone growth.
When to interrupt dosage
The measure of Forteo is contingent upon the diagnosed affliction, including Osteoporosis brought about by glucocorticoid, Osteoporosis and Low Testosterone. The amount also fluctuates as per the technique of delivery (e.g. Subcutaneous or Solution) delineated in the table beneath.Condition
Dosage
Administration
Osteoporosis
, 0.25 mg/mL, 0.75 mg/mL, 2.0 mg/mL
, Solution, Subcutaneous, Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous
Low Testosterone
, 0.25 mg/mL, 0.75 mg/mL, 2.0 mg/mL
, Solution, Subcutaneous, Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous
Osteoporosis
, 0.25 mg/mL, 0.75 mg/mL, 2.0 mg/mL
, Solution, Subcutaneous, Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous
Osteoporosis caused by glucocorticoid
, 0.25 mg/mL, 0.75 mg/mL, 2.0 mg/mL
, Solution, Subcutaneous, Solution - Subcutaneous, Injection, solution, Injection, solution - Subcutaneous
Warnings
There are 20 known major drug interactions with Forteo.Common Forteo Drug Interactions
Drug Name
Risk Level
Description
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Teriparatide.
Carbutamide
Minor
The therapeutic efficacy of Carbutamide can be decreased when used in combination with Teriparatide.
Chlorpropamide
Minor
The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Teriparatide.
Glibornuride
Minor
The therapeutic efficacy of Glibornuride can be decreased when used in combination with Teriparatide.
Gliclazide
Minor
The therapeutic efficacy of Gliclazide can be decreased when used in combination with Teriparatide.
Forteo Toxicity & Overdose RiskThe lethal dose of teriparatide when given subcutaneously or intravenously in rats is 1000µg/m3 and 300µg/m3, respectively. In rare cases, people have accidentally been given 40 times the recommended dose of 800mcg, which resulted in nausea, weakness, lethargy, and low blood pressure. As there is no antidote for an overdose, treatment should involve stopping the teriparatide and monitoring calcium and phosphorus levels in the blood, as well as providing supportive measures such as hydration.
Forteo Novel Uses: Which Conditions Have a Clinical Trial Featuring Forteo?
62 active studies are being conducted to assess the potential of Forteo to alleviate Osteoporosis, Low Testosterone and related Osteoporotic conditions.Condition
Clinical Trials
Trial Phases
Osteoporosis caused by glucocorticoid
0 Actively Recruiting
Osteoporosis
0 Actively Recruiting
Low Testosterone
15 Actively Recruiting
Phase 1, Phase 4, Phase 2, Not Applicable
Osteoporosis
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3
Forteo Reviews: What are patients saying about Forteo?
5Patient Review
6/3/2019 I was so pleased with the results of this treatment. It not only repaired my broken bones, but it also strengthened the surrounding areas to prevent any future breakage.
4.7Patient Review
3/31/2019 The injection was simple, but I experienced stomach cramps about 20 minutes later.
4Patient Review
4/19/2021 I've had no issues with side effects and the needle injections are really not that bad. After one year of treatment, I saw a significant improvement in my bone density test results. Hoping for similar results this coming May from my second-year tests.
3.7Patient Review
11/30/2020 I took this medication for 18 months before I stopped. I gained weight while on it, but eventually got tired of having to inject myself daily. I then switched to Evista for a couple years, which helped me lose the weight again. However, now that I'm back on Forteo (for the final 6 months that my insurance will cover), I've been having problems with my memory. Not sure if it's related to the drug or not...
3Patient Review
7/8/2020 I am on my fourth month of Forteo for osteoporosis prevention. So far, no fractures or broken bones. I walk 4 miles several times a week and don't have any other health issues. However, by the third month, I started feeling occasional nausea which quickly became constant fatigue. I messaged my doctor and will now inject every other day to see if I can tolerate it better. My non-fasting lab showed elevated glucose of 145 which is new for me.
3Patient Review
4/22/2020 I've been using Forteo for a year now. My L spine was -3.7 a year ago and it's only at -3.1 now, which isn't that great of an improvement. My femur went from -1.5 to -2.4, so there hasn't been much progress there either unfortunately..
2.7Patient Review
7/27/2020 Since beginning this treatment, I've experienced an increase in pain and nausea with each injection. I'm now trying to every third day in order to try and get some benefit for my bones. The side effects are really taking a toll though.
2.3Patient Review
2/14/2019 I did not experience any benefits from this medication, and unfortunately about three months after starting the shots I lost a tooth. Be aware of the potential side effects before trying this treatment.
2Patient Review
9/6/2022 After just a few doses, I started having excruciating pain in my knee and leg. It got so bad that I couldn't walk without assistance. Needless to say, I stopped taking the medication and feel like I wasted a ton of money. Now, I don't know what to do about my osteoporosis.
1.7Patient Review
11/11/2022 The last unit I received was defective, and when I contacted the company they gave me a run-around rather than taking responsibility. It's hard enough to use this product as it is; having to deal with customer service on top of that is really frustrating.
Patient Q&A Section about forteo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the dangers of Forteo?
"One common side effect of this medication is feeling faint, tired, or confused."
Answered by AI
Is Forteo a daily injection?
"Forteo is typically given as a single daily injection beneath the skin. A common dosage is 20 micrograms (mcg) once per day."
Answered by AI
Does Forteo build bone?
"Forteo is a medication used to treat osteoporosis. It is a synthetic version of the human parathyroid hormone, which promotes the growth of new bone. Other osteoporosis medications work by inhibiting bone resorption, or breakdown."
Answered by AI
What does the drug Forteo do?
"Forteo (teriparatide injection) can reduces your risk of another fracture. It is a prescription medicine used to treat postmenopausal women who have osteoporosis who are at high risk for having broken bones (fractures) or who cannot use other osteoporosis treatments."
Answered by AI