Monurol

Urinary tract infection, Escherichia coli, Enterococcus faecalis

Treatment

2 FDA approvals

0 Active Studies for Monurol

Treatment for

Urinary tract infection

What is Monurol

FosfomycinThe Generic name of this drug

Treatment SummaryFosfomycin is an antibiotic discovered in 1969 by Spanish scientists. It is available in both oral and intravenous forms, and is usually taken as a single 3-gram dose. Fosfomycin is most commonly used to treat uncomplicated urinary tract infections in women, but it has a broad spectrum of activity and can be used to treat other bacterial infections. This drug is generally well tolerated with a good safety profile.

Monurolis the brand name

image of different drug pills on a surface

Monurol Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Monurol

Fosfomycin

1996

Approved as Treatment by the FDA

Fosfomycin, also known as Monurol, is approved by the FDA for 2 uses such as Enterococcus faecalis and Escherichia coli .

Enterococcus faecalis

Escherichia coli

Effectiveness

How Monurol Affects PatientsFosfomycin is primarily used to treat urinary tract infections, but has also been found to work with other antibiotics to fight bacteria. It has been effective against certain tough-to-treat bacteria like MRSA and multi-drug resistant enterobacteria. This is because fosfomycin works differently than other antibiotics, meaning there is a lower chance of it becoming resistant. Fosfomycin can also help the body's immune system by modifying the response to inflammation and helping white blood cells destroy germs. Additionally, fosfomycin is able to penetrate and break down biofilms, and can kill bacteria

How Monurol works in the bodyFosfomycin works by disabling a key enzyme that helps create bacterial cell walls. By blocking the enzyme, it prevents bacteria from forming the structure that holds them together. Fosfomycin is also able to enter bacterial cells in two different ways, allowing it to do its job more effectively. Finally, it can stop bacteria from attaching to cells in areas like the urinary or respiratory tract.

When to interrupt dosage

The amount of Monurol is contingent upon the determined affliction, including Urinary tract infection, Enterococcus faecalis and Escherichia coli. Dosage varies, based on the method of administration (e.g. Powder, for solution - Intravenous or Oral) featured in the table beneath.

Condition

Dosage

Administration

Urinary tract infection

, 3000.0 mg, 2000.0 mg, 8000.0 mg, 4000.0 mg

, Oral, Powder, Powder - Oral, Powder, for solution, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Oral, Granule, for solution, Granule, for solution - Oral

Escherichia coli

, 3000.0 mg, 2000.0 mg, 8000.0 mg, 4000.0 mg

, Oral, Powder, Powder - Oral, Powder, for solution, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Oral, Granule, for solution, Granule, for solution - Oral

Enterococcus faecalis

, 3000.0 mg, 2000.0 mg, 8000.0 mg, 4000.0 mg

, Oral, Powder, Powder - Oral, Powder, for solution, Intravenous, Powder, for solution - Intravenous, Powder, for solution - Oral, Granule, for solution, Granule, for solution - Oral

Warnings

Monurol Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Fosfomycin may interact with Pulse Frequency

There are 20 known major drug interactions with Monurol.

Common Monurol Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Fosfomycin.

Abacavir

Minor

Fosfomycin may decrease the excretion rate of Abacavir which could result in a higher serum level.

Aclidinium

Minor

Fosfomycin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Fosfomycin may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Fosfomycin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Monurol Toxicity & Overdose RiskAnimals have been found to tolerate doses of fosfomycin up to 50-125 times higher than what is typically prescribed to humans without any severe side effects, though some rabbits and dogs experienced minor to moderate diarrhea. For humans, an overdose may lead to hearing loss, balance issues, reduced taste perception, and a metallic taste. If someone overdoses on fosfomycin, they should be given treatment to alleviate their symptoms and provide supportive care.

Monurol Novel Uses: Which Conditions Have a Clinical Trial Featuring Monurol?

Two investigations are currently being conducted to analyze the effect of Monurol in treating Enterococcus faecalis, Urinary tract infection and Escherichia coli.

Condition

Clinical Trials

Trial Phases

Urinary tract infection

0 Actively Recruiting

Enterococcus faecalis

0 Actively Recruiting

Escherichia coli

0 Actively Recruiting

Monurol Reviews: What are patients saying about Monurol?

5Patient Review

8/6/2018

Monurol for Bacterial Urinary Tract Infection

Unfortunately, this led to some sudden and intense diarrhea. However, it did clear up the infection within three days.

5Patient Review

2/6/2022

Monurol for Urinary Tract Infection

This medication worked very well for me, despite some initial digestive issues. I'm really happy to have found a solution that works.

5Patient Review

11/26/2021

Monurol for Bacterial Urinary Tract Infection

I really wish my doctor had prescribed this to me sooner. I get UTIs semi-regularly and the pills are always so unpleasant, not to mention easy to forget. This product is excellent.

5Patient Review

9/6/2019

Monurol for Urinary Tract Infection

I was very hesitant to try this, as it just seemed like a packet of flavored powder. I'm also allergic to many antibiotics, but I decided to give it a chance. Within 3 hours of taking it, all my symptoms had disappeared. No more bloating, burning, or needing to go constantly. This drug is amazing! The only downside is the stomach cramps that come along with it; however, they were manageable.

4Patient Review

2/3/2019

Monurol for Urinary Tract Infection

I've tried Monurol a few times now to treat my UTIs, but I haven't had any luck with it. Each time, the infection comes back within a few months.

View All Reviews

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about monurol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is monurol a good antibiotic?

"Most people who voted found this review helpful. Monurol is a great medication for treating UTIs. It always works for me, getting rid of the infection and the accompanying pain, burning, and urgency."

Answered by AI

How long does it take monurol to work?

"You should notice an improvement in your symptoms within 2 to 3 days of taking fosfomycin (Monurol). However, if your symptoms do not improve, contact your healthcare provider."

Answered by AI

How long does it take for monurol to work for UTI?

"Although MONUROL only needs to be taken once, it is designed to remain in your bladder for more than three days in order to continuously kill the bacteria. MONUROL should start working to kill bacteria a few hours after taking it. As a result, you should experience an improvement in your symptoms after two or three days."

Answered by AI

What is monurol used to treat?

"This is an antibiotic that is used to treat bladder infections in women. It works by stopping the growth of bacteria. This antibiotic can only treat bacterial infections and not viral infections."

Answered by AI