Polaramine

Catarrh, Angioedema, Hives + 4 more
Treatment
11 FDA approvals
4 Active Studies for Polaramine

What is Polaramine

Dexchlorpheniramine maleateThe Generic name of this drug
Treatment SummaryDexchlorpheniramine is a type of anti-histamine used to treat allergy symptoms. It is a single form of the drug chlorpheniramine, which is more powerful and effective than other forms.
Dexchlorpheniramine Maleateis the brand name
image of different drug pills on a surface
Polaramine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dexchlorpheniramine Maleate
Dexchlorpheniramine maleate
1984
4

Approved as Treatment by the FDA

Dexchlorpheniramine maleate, also known as Dexchlorpheniramine Maleate, is approved by the FDA for 11 uses which include Allergic Rhinitis (AR) and Vasomotor Rhinitis .
Allergic Rhinitis (AR)
Helps manage Allergic Rhinitis (AR)
Vasomotor Rhinitis
Helps manage Vasomotor Rhinitis
Angioedema
Helps manage Angioedema
Urticaria
Helps manage Urticaria
Catarrh
Rhinitis, Vasomotor
Helps manage Vasomotor Rhinitis
Hypersensitivity
Hives
Helps manage Urticaria
Allergic Conjunctivitis (AC)
Helps manage Allergic Conjunctivitis (AC)
Angioedema
Helps manage Angioedema
Dermographism
Helps manage Dermographism

Effectiveness

How Polaramine Affects PatientsAllergic reactions occur when allergens attach to IgE antibodies on mast cells and basophils. This triggers the release of histamine and other chemicals, which can cause itching, flushing, headaches, and other symptoms. Dexchlorpheniramine is a drug that helps relieve these symptoms by blocking histamine from attaching to H1-receptors. It can provide temporary relief from sneezing, itchy eyes, runny nose and other issues caused by hay fever and allergies.
How Polaramine works in the bodyDexchlorpheniramine blocks the effects of histamine, which is a chemical that can cause swelling, itching, and other reactions. It does this by competing with histamine for sites on cells in the gut, blood vessels, and airways. Dexchlorpheniramine is more effective than regular chlorpheniramine in blocking histamine.

When to interrupt dosage

The recommended amount of Polaramine is contingent upon the determined circumstance, including Allergic Conjunctivitis (AC), Angioedema and Hay Fever. The dosage is contingent upon the mode of administration as stated in the table below.
Condition
Dosage
Administration
Catarrh
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Liquid, Liquid - Oral, Solution / drops, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Angioedema
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Liquid, Liquid - Oral, Solution / drops, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Hives
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Liquid, Liquid - Oral, Solution / drops, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Dermographism
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Liquid, Liquid - Oral, Solution / drops, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Rhinitis, Vasomotor
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Liquid, Liquid - Oral, Solution / drops, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Hypersensitivity
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Liquid, Liquid - Oral, Solution / drops, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Allergic Conjunctivitis (AC)
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
, Oral, Tablet, coated, Tablet, coated - Oral, Liquid, Liquid - Oral, Solution / drops, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral

Warnings

There are 20 known major drug interactions with Polaramine.
Common Polaramine Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Dexchlorpheniramine maleate.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Dexchlorpheniramine maleate.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Artemether.
Polaramine Toxicity & Overdose RiskOverdosing on a drug can cause decreased activity in the brain and nervous system.
image of a doctor in a lab doing drug, clinical research

Polaramine Novel Uses: Which Conditions Have a Clinical Trial Featuring Polaramine?

A total of 150 active trials are ongoing to ascertain the potential of Polaramine in alleviating Allergy, Dermographism and Catarrhal Symptoms.
Condition
Clinical Trials
Trial Phases
Angioedema
2 Actively Recruiting
Phase 2, Phase 4
Hives
1 Actively Recruiting
Phase 2
Hypersensitivity
0 Actively Recruiting
Allergic Conjunctivitis (AC)
2 Actively Recruiting
Phase 3
Catarrh
0 Actively Recruiting
Rhinitis, Vasomotor
0 Actively Recruiting
Dermographism
0 Actively Recruiting

Polaramine Reviews: What are patients saying about Polaramine?

5Patient Review
10/7/2009
Polaramine for Allergic Conjunctivitis
Took this drug for years and it really worked. I stopped taking it and still haven't had any allergic reactions, which is amazing.
2.3Patient Review
7/5/2015
Polaramine for Itching
I was recommended this by my GP for mosquito bites, but it didn't work at all. The only upside is that it made me sleepy.

Patient Q&A Section about polaramine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Polaramine?

"The following side effects may occur: drowsiness, dizziness, constipation, stomach upset, blurred vision, or dryness of the mouth, nose, or throat. If you experience any of these side effects, tell your doctor or pharmacist immediately."

Answered by AI

Is Polaramine a sedative?

"Polaramine may make you sleepy and magnify the effects of alcohol. Sleepiness may persist into the next day. Do not drive or operate machinery if affected; stay away from alcohol."

Answered by AI

What is Polaramine used for?

"Polaramine is a medication used to relieve symptoms associated with allergies, such as sneezing, a runny or itchy nose, and burning or itchy eyes. Polaramine can also be used to relieve symptoms associated with hives."

Answered by AI

Is Polaramine a steroid?

"Polaramine is an antihistamine that blocks the effects of histamine in your body. It is used to relieve symptoms of allergies and the common cold such as sneezing, runny nose, itching, watery eyes, hives, rashes, and itching."

Answered by AI

Clinical Trials for Polaramine

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Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
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