Polaramine

Catarrh, Angioedema, Hives + 4 more

Treatment

11 FDA approvals

5 Active Studies for Polaramine

What is Polaramine

Dexchlorpheniramine maleate

The Generic name of this drug

Treatment Summary

Dexchlorpheniramine is a type of anti-histamine used to treat allergy symptoms. It is a single form of the drug chlorpheniramine, which is more powerful and effective than other forms.

Dexchlorpheniramine Maleate

is the brand name

image of different drug pills on a surface

Polaramine Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Dexchlorpheniramine Maleate

Dexchlorpheniramine maleate

1984

4

Approved as Treatment by the FDA

Dexchlorpheniramine maleate, also known as Dexchlorpheniramine Maleate, is approved by the FDA for 11 uses which include Vasomotor Rhinitis and Allergic Rhinitis (AR) .

Vasomotor Rhinitis

Helps manage Vasomotor Rhinitis

Allergic Rhinitis (AR)

Helps manage Allergic Rhinitis (AR)

Angioedema

Helps manage Angioedema

Urticaria

Helps manage Urticaria

Catarrh

Rhinitis, Vasomotor

Helps manage Vasomotor Rhinitis

Hypersensitivity

Hives

Helps manage Urticaria

Allergic Conjunctivitis (AC)

Helps manage Allergic Conjunctivitis (AC)

Angioedema

Helps manage Angioedema

Dermographism

Helps manage Dermographism

Effectiveness

How Polaramine Affects Patients

Allergic reactions occur when allergens attach to IgE antibodies on mast cells and basophils. This triggers the release of histamine and other chemicals, which can cause itching, flushing, headaches, and other symptoms. Dexchlorpheniramine is a drug that helps relieve these symptoms by blocking histamine from attaching to H1-receptors. It can provide temporary relief from sneezing, itchy eyes, runny nose and other issues caused by hay fever and allergies.

How Polaramine works in the body

Dexchlorpheniramine blocks the effects of histamine, which is a chemical that can cause swelling, itching, and other reactions. It does this by competing with histamine for sites on cells in the gut, blood vessels, and airways. Dexchlorpheniramine is more effective than regular chlorpheniramine in blocking histamine.

When to interrupt dosage

The recommended amount of Polaramine is contingent upon the determined circumstance, including Allergic Conjunctivitis (AC), Angioedema and Hay Fever. The dosage is contingent upon the mode of administration as stated in the table below.

Condition

Dosage

Administration

Catarrh

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Liquid - Oral, Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Syrup - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Syrup

Angioedema

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Liquid - Oral, Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Syrup - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Syrup

Hives

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Liquid - Oral, Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Syrup - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Syrup

Dermographism

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Liquid - Oral, Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Syrup - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Syrup

Rhinitis, Vasomotor

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Liquid - Oral, Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Syrup - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Syrup

Hypersensitivity

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Liquid - Oral, Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Syrup - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Syrup

Allergic Conjunctivitis (AC)

, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg

Tablet, coated - Oral, , Tablet, coated, Liquid - Oral, Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution, Solution - Oral, Tablet, multilayer, Tablet, multilayer - Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Syrup - Oral, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Syrup

Warnings

There are 20 known major drug interactions with Polaramine.

Common Polaramine Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Dexchlorpheniramine maleate.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Dexchlorpheniramine maleate.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Artemether.

Polaramine Toxicity & Overdose Risk

Overdosing on a drug can cause decreased activity in the brain and nervous system.

image of a doctor in a lab doing drug, clinical research

Polaramine Novel Uses: Which Conditions Have a Clinical Trial Featuring Polaramine?

A total of 150 active trials are ongoing to ascertain the potential of Polaramine in alleviating Allergy, Dermographism and Catarrhal Symptoms.

Condition

Clinical Trials

Trial Phases

Angioedema

2 Actively Recruiting

Phase 4, Phase 1, Phase 2

Hives

0 Actively Recruiting

Hypersensitivity

1 Actively Recruiting

Phase 4

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 2

Catarrh

0 Actively Recruiting

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Dermographism

0 Actively Recruiting

Polaramine Reviews: What are patients saying about Polaramine?

5

Patient Review

10/7/2009

Polaramine for Allergic Conjunctivitis

Took this drug for years and it really worked. I stopped taking it and still haven't had any allergic reactions, which is amazing.

2.3

Patient Review

7/5/2015

Polaramine for Itching

I was recommended this by my GP for mosquito bites, but it didn't work at all. The only upside is that it made me sleepy.

Patient Q&A Section about polaramine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of Polaramine?

"The following side effects may occur: drowsiness, dizziness, constipation, stomach upset, blurred vision, or dryness of the mouth, nose, or throat. If you experience any of these side effects, tell your doctor or pharmacist immediately."

Answered by AI

Is Polaramine a sedative?

"Polaramine may make you sleepy and magnify the effects of alcohol. Sleepiness may persist into the next day. Do not drive or operate machinery if affected; stay away from alcohol."

Answered by AI

What is Polaramine used for?

"Polaramine is a medication used to relieve symptoms associated with allergies, such as sneezing, a runny or itchy nose, and burning or itchy eyes. Polaramine can also be used to relieve symptoms associated with hives."

Answered by AI

Is Polaramine a steroid?

"Polaramine is an antihistamine that blocks the effects of histamine in your body. It is used to relieve symptoms of allergies and the common cold such as sneezing, runny nose, itching, watery eyes, hives, rashes, and itching."

Answered by AI

Clinical Trials for Polaramine

Image of Cedars-Sinai Medical Center Otolaryngology Clinics in Los Angeles, United States.

Lavender Aromatherapy for Anxiety and Pain During Otolaryngologic Procedures

18+
All Sexes
Los Angeles, CA

The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting. The main questions it aims to answer are: * Does lavender aromatherapy help reduce anxiety and/or pain, and improve patient comfort during awake otolaryngologic procedures in the clinic? * Do patients subjectively find aromatherapy relaxing and/or beneficial during the procedure? Researchers will compare lavender aromatherapy to placebo (an odorless liquid) to see if lavender aromatherapy helps improve patient comfort during their awake procedure Participants will: * Have their scheduled procedure performed with lavender aromatherapy or placebo during the duration of the procedure * Take a short, less than 1 minute questionnaire both before and after the procedure, describing their levels of anxiety, pain and subjective impressions of the aromatherapy

Recruiting
Paid Trial

Cedars-Sinai Medical Center Otolaryngology Clinics

Ankona Ghosh, MD

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