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Carvedilol for Preventing Heart Failure in Childhood Cancer Survivors
Study Summary
This trial tests how well low-dose carvedilol prevents heart failure in cancer survivors who were exposed to high-dose anthracyclines. Carvedilol may help lower the risk of cardiovascular complications.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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- Your blood doesn't have enough red cells.I don't have stomach or liver problems affecting medication absorption.My hormone-related condition is not controlled by medication.My diabetes is under control with an A1C level below 7%.I am currently taking specific medications that affect drug metabolism.I am not pregnant and have a negative pregnancy test.I have a serious heart rhythm problem.Your heart's ability to pump blood is too low, as measured by specific tests.I received a high dose of a specific chemotherapy drug for cancer treated before I was 22.I was diagnosed with cancer before turning 22.Your resting systolic blood pressure is less than 90 mmHg.I have moderate-to-severe lung problems like asthma that need treatment.I haven't taken any blood pressure medication except for calcium channel blockers or diuretics in the last 30 days.I do not have severe heart valve problems or thickened heart muscles causing obstruction.Your liver enzymes (AST and ALT) are more than three times the normal limit.You have had a bad reaction to alpha or beta-blocker medications in the past.I am using effective birth control or practicing abstinence while on the study drug and for 2 months after.I am currently being treated for heart issues.I have heart rhythm problems not controlled by medication or devices.Your heart beats too slowly, less than 50 beats per minute.I haven't taken any experimental drugs or beta blockers like metoprolol in the last 30 days.I cannot swallow pills.I weigh at least 40 kg.I finished my cancer treatment more than 2 years ago.
- Group 1: Arm I (carvedilol)
- Group 2: Arm II (placebo)
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
At how many hospitals is this trial being conducted?
"87 clinical trial sites are currently participating in this study, with locations spanning from Baltimore to Hackensack. If you're interested in enrolling, we recommend finding the location nearest to you in order to cut down on travel costs and time commitment."
Is there a risk to patients when they answer questions for a study?
"While there is some evidence that this questionnaire administration is safe, it only received a 2 because there is no data supporting efficacy."
What are some other examples of research that has used questionnaire administration?
"The first clinical trial studying Questionnaire Administration occurred in 2012 at the University of Calgary. Out of the 837 completed trials, 29 are still ongoing with several taking place in Baltimore, Maryland."
What disorders does Questionnaire Administration help to alleviate symptoms for?
"While hypertensive disease is most frequently treated with Questionnaire Administration, this method can also be used to mitigate the effects of heart failure, hypesthesia, and left ventricular dysfunction."
How many people are included in this research project?
"Unfortunately, this particular trial has wrapped up recruitment. Though, it is worth noting that there are plenty of other studies currently underway that may be of interest. For example, there are 3240 trials actively recruiting cancer patients and 29 for Questionnaire Administration."
Are there any more places open for people who want to participate in this experiment?
"This clinical trial is not presently seeking participants anymore. The clinical trial was originally posted on 4/4/2016 and was most recently edited on 9/30/2022. If you are seeking for other studies, there are presently 3240 clinical trials actively recruiting participants with cancer and 29 trials for Questionnaire Administration actively looking for patients."
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