Lanadelumab for Angioedema
Trial Summary
What is the purpose of this trial?
use of lanadelumab in patients with acquired angioedema
Will I have to stop taking my current medications?
The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the drug Lanadelumab for treating angioedema?
Is lanadelumab safe for humans?
Lanadelumab is generally well tolerated in humans, with the most common side effects being mild and temporary reactions at the injection site. It has a low potential for causing immune reactions and is considered a safe option for preventing hereditary angioedema attacks in patients aged 12 and older.13678
How is the drug Lanadelumab different from other treatments for angioedema?
Lanadelumab is unique because it is a fully human monoclonal antibody that targets and inhibits plasma kallikrein, which helps prevent hereditary angioedema attacks. Unlike some other treatments, it is administered subcutaneously (under the skin) and is designed for long-term prevention rather than on-demand treatment.13589
Research Team
Jonathan Bernstein, MD
Principal Investigator
5139314181
Eligibility Criteria
This trial is for patients with acquired angioedema who experience at least one attack per month and have specific lab findings like decreased C1INH, C4, and C1q levels. It's not open to pregnant or breastfeeding women, those with hereditary angioedema types 1 or 2, people allergic to biologics, or anyone with uncontrolled systemic diseases.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive open-label lanadelumab for prophylaxis of acquired angioedema
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Lanadelumab
Find a Clinic Near You
Who Is Running the Clinical Trial?
Bernstein Clinical Research Center
Lead Sponsor