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Procedure

Dusting vs. Basket Extraction for Kidney Stones and Ureter Stones

N/A
Recruiting
Led By Amy Krambeck, MD
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
≥18 years of age
Stone size ≥6mm and located in mid ureter or higher
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Study Summary

This trial will compare the two methods to see which is more effective in breaking down and removing stones while also causing fewer side effects for patients.

Who is the study for?
This trial is for adults over 18 with kidney or ureteral stones at least 6mm large, who are undergoing a specific stone removal procedure and can consent to the study. It's not for those under 18, with only one kidney, certain kidney conditions, without phone access, needing additional surgeries, or in vulnerable groups.Check my eligibility
What is being tested?
The study compares two methods of removing kidney and ureteral stones: 'dusting' using a laser to break down stones so they pass in urine versus 'basket extraction' where fragments are physically removed with a wire basket.See study design
What are the potential side effects?
Potential side effects may include discomfort from passing small stone fragments after dusting or complications related to the use of the wire basket during extraction. Patient satisfaction and any side effects will be closely monitored.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I have a kidney stone that is 6mm or larger, located in the middle or upper part of my ureter.
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I am scheduled for a procedure to remove kidney stones using a scope.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Stone free rate: clinical
Stone free rate: imaging
Secondary outcome measures
Daily activity level
Patient quality of life- pain intensity
Patient quality of life- pain interference
+1 more

Trial Design

2Treatment groups
Active Control
Group I: laser dustingActive Control1 Intervention
In the "dusting" arm, the ureteroscope will be advanced into the kidney or ureter over an access wire without an access sheath in place. The identified stone will be dusted using a 200 micron Moses laser fiber at a setting of 0.3-0.6 J and 50-120 Hz using the Moses 2.0 laser system. Stone dusting will continue until the surgeon feels the fragments are all negligible in size and would be able to pass. One small piece will be extracted for analysis and the remainder will be left to pass spontaneously. If there is no evidence of injury or swelling of the ureter at the conclusion of the case a stent will be omitted.
Group II: basketingActive Control1 Intervention
In the Basketing arm, a ureteral access sheath (UAS) will be placed per standard fashion. The ureteroscope will be introduced into the kidney and the stone fragmented at a setting of 0.8-1.0 J and 6-15 Hz. The resultant fragments will be basket extracted through the sheath for analysis. All fragments will be removed until no residual stone remains. At the time of UAS removal the ureter will be inspected. If there is no evidence of ureteral injury or swelling then a stent will be omitted.

Find a Location

Who is running the clinical trial?

Northwestern UniversityLead Sponsor
1,580 Previous Clinical Trials
916,679 Total Patients Enrolled
3 Trials studying Kidney Stones
166 Patients Enrolled for Kidney Stones
Amy Krambeck, MDPrincipal Investigator - Northwestern University
Jesse Brown VA Medical Center- Lakeside Clinic-CBOC, Northwestern Lake Forest Hospital
University Of Mo (Medical School)
Mayo Grad School Med/Mayo Fndn (Residency)
1 Previous Clinical Trials
80 Total Patients Enrolled

Media Library

Basket extraction (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT05006937 — N/A
Kidney Stones Research Study Groups: laser dusting, basketing
Kidney Stones Clinical Trial 2023: Basket extraction Highlights & Side Effects. Trial Name: NCT05006937 — N/A
Basket extraction (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05006937 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment in this clinical test still taking place?

"Affirmative. Information found on clinicaltrials.gov indicates that this medical trial, which initially appeared online in late July 2021, is still recruiting participants. The study aims to enrol 168 patients from a single location."

Answered by AI

Does this trial offer me the opportunity to participate?

"This research requires participants to possess kidney stones and be between 18-89 years old. Approximately 168 people have been invited to take part in the experiment thus far."

Answered by AI

What core goals is this clinical trial attempting to achieve?

"This 6 week long trial primarily looks to measure the Stone Free Rate: Clinical. Additionally, data will be collected in relation to Patient Quality of Life- Pain Intensity (rated from 3 to 15) and Interference (ranging from 6-30), as well as Return To Work Time."

Answered by AI

To what extent is this trial populated with participants?

"Affirmative. Clinicaltrials.gov displays evidence that this clinical trial is actively seeking participants, with the first posting on July 28th 2021 and a subsequent update made August 13th 2021. In total, 168 persons need to be sourced from single medical centre for this study."

Answered by AI

Is the scope of this research limited to individuals above a certain age?

"In order to be considered for this trial, participants must meet the age requirement of 18 or over and under 89."

Answered by AI
~46 spots leftby Mar 2025