We report here a novel cause of immune-mediated hypersensitivity in which a low-dose immunotherapy is initiated in non-immune-mediated patients and in patients with only mild disease. To our knowledge, this is the first report of a hypersensitivity syndrome of that type, in which the most likely causes are immunologic dysregulation of the B lymphocyte compartment and a hyperreactive Th17 cellular milieu. In a recent study, findings suggest a role for a low-dose immunotherapy tailored to the cause of hypersensitivity and its response.
Symptoms of anaphylaxis last for 4 hours or longer. Symptoms of [food [allergy](https://www.withpower.com/clinical-trials/allergy)](https://www.withpower.com/clinical-trials/food-allergy) last for 2 weeks or longer. The symptoms of atopy last 4 hours or longer. Symptoms of systemic allergic reaction last 12 hours or more. Symptoms of drug allergy last from 2 weeks to 14 days or more.
We provide a basic understanding of how certain foods or drugs cause allergic reactions, which may contribute to more serious reactions, such as anaphylaxis which can be life-threatening. This article does not discuss all possibilities for hypersensitivity. To help the reader develop appropriate action plans to respond to allergic reactions to foods and medicines, see the article Allergy and anaphylaxis.
Hypersensitivity does not have to be cured. For the hypersensitive person, the only way to be cured would be to get rid of all the triggers. In addition the hypersensitive person would have to be prepared to live with the trigger, even at the expense of not being able to see anyone (cf. "cure and stay well", a coping strategy in chronic illnesses).
This is one of the largest studies to date to estimate the prevalence of hypersensitivity in a population. The prevalence of symptomatic hypersensitivity ranged from 0.3% to 2.9%, and the prevalence of severe hypersensitivity ranged from 0.9% to 4.8%. These observations highlight the need for further studies to refine our estimates of the extent of hypersensitivity reactions in a population and to increase attention to and awareness of hypersensitivity reactions by clinicians and patients.
Non-prescription drugs are typically effective for treatment of hypersensitivity conditions, but may not always be the most efficient as in some cases prescription drugs may improve the clinical manifestations or resolve adverse drug side-effects.
OIT was found to be safe for people with [food allergy](https://www.withpower.com/clinical-trials/food-allergy). There are many factors and circumstances that can influence the potential of multiple food oral immunotherapy (oit) to be a success. As such, patients’ allergy histories, their response to oit, and compliance to the treatment are key factors in a successful oit outcome.
Previous oit trials had a low number of patients and a lack of standardized treatment methodology. The present trial is the first large multi food OIT trial, using an optimized protocol as an exploratory pilot study. Further, the present trial is one of the largest oit trials, including patients from more than 30 countries, and evaluating OIT using oral administration of food allergens and multiple targets. It is estimated that an additional 60,000 patients would qualify for a full multicenter trial in the United States to evaluate the efficacy and safety of allergen-specific OIT, or to evaluate OIT versus placebo. We hope to provide a valuable contribution to the existing literature on the use of OIT in atopic and other food allergies.
This is the first study to report a familial aggregation of allergic rhinitis in a small German population. The fact that familial aggregation is well established for non-allergic rhinitis, in this study confirms the need for studies aiming at a full investigation of allergic airway diseases.
In this pilot study, patients tolerated multi-food oit, and all displayed clinically relevant, but transient, decreases in food allergen-specific IgE antibodies and total IgE levels.
Clinical trials are being increasingly recruited into hypersensitivity conditions which were previously considered unsuitable for this purpose. Clinicians must be better educated and made more aware of these special circumstances so that they can make informed treatment decisions for hypersensitivity patients.
Since the last year there have been few new discoveries made in the field of hypersensitivity treatment. The new discoveries have improved the efficiency of hypersensitivity treatment, and they have also reduced the dosage required for treatment.