Nicotine Replacement Therapy for Quitting Smoking
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests the effectiveness of nicotine replacement therapy (NRT) in helping people quit smoking when initiated in the emergency department. Participants will receive either NRT, which includes products like nicotine patches or gum, or standard advice and support for quitting smoking. The trial aims to determine if NRT increases the number of people who quit smoking after 2 weeks, 1 month, and 3 months compared to usual methods. Eligible participants smoke at least half a pack of cigarettes daily, are ready to leave the emergency room, and can follow up by phone or online. As a Phase 4 trial, this study uses an FDA-approved treatment to understand its benefits for more patients, offering a proven method to help quit smoking.
Do I have to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What is the safety track record for Nicotine Replacement Therapy?
Previous studies have shown that nicotine replacement therapy (NRT) is safe for helping people quit smoking. Research shows that while NRT can cause some side effects, they are usually mild and not harmful. Common side effects include headaches, dizziness, and an upset stomach, which are generally manageable and resolve on their own.
NRT is widely used and nearly doubles the chances of quitting smoking compared to not using it. It provides a small, controlled amount of nicotine to help manage cravings and withdrawal symptoms, making it easier to quit smoking.
Overall, NRT is well-tolerated and considered a safe option for those looking to quit smoking.12345Why are researchers enthusiastic about this study treatment?
Unlike the standard of care for quitting smoking, which often includes medications like bupropion or varenicline, Nicotine Replacement Therapy (NRT) offers a different approach by directly replacing nicotine to ease withdrawal symptoms. Researchers are excited about NRT because it provides smokers with a controlled, low-dose supply of nicotine without the harmful chemicals found in cigarettes, potentially making the quitting process smoother. Additionally, pairing NRT with resources like the West Virginia Quit Line could enhance support, offering a comprehensive approach to help individuals quit smoking more effectively.
What is the effectiveness track record for Nicotine Replacement Therapy in quitting smoking?
Research shows that Nicotine Replacement Therapy (NRT), which participants in this trial may receive, helps people quit smoking. Studies have found that NRT can control cravings and ease withdrawal symptoms. Combining nicotine patches with fast-acting options like gum or lozenges can increase the chances of quitting. One study found that higher doses of nicotine patches slightly improved success rates. Overall, NRT is a proven and common method for those wanting to quit smoking.16789
Who Is on the Research Team?
Bradley End
Principal Investigator
West Virginia University
Are You a Good Fit for This Trial?
This trial is for individuals who use tobacco and are seeking to quit, particularly those visiting the emergency department. Specific eligibility criteria details were not provided.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive a 2-week supply of Nicotine Replacement Therapy (NRT) and a West Virginia Quit Line fact sheet/contact information
Follow-up
Participants are monitored for tobacco cessation point abstinence rates at 2 weeks, 1 month, and 3 months post randomization
What Are the Treatments Tested in This Trial?
Interventions
- Nicotine Replacement Therapy
Trial Overview
The study aims to test if starting Nicotine Replacement Therapy (NRT) in the emergency department helps people quit smoking better than the usual care. Success is measured by whether patients have stopped smoking after 2 weeks, 1 month, and at 3 months post-treatment.
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Subject will be provided with a box/bag containing a WV QL fact sheet/contact information.
Subject provided with a 2-week supply of NRT and a West Virginia Quit Line (WV QL) fact sheet/contact information.
Nicotine Replacement Therapy is already approved in United States, European Union, Canada, Japan for the following indications:
- Smoking cessation
- Smoking cessation
- Smoking cessation
- Smoking cessation
Find a Clinic Near You
Who Is Running the Clinical Trial?
West Virginia University
Lead Sponsor
Citations
Nicotine Replacement Therapy - StatPearls - NCBI Bookshelf
NRTs are designed to replicate the nicotine response typically experienced through smoking, thereby helping individuals manage cravings and withdrawal symptoms.
Nicotine replacement therapy for smoking cessation
Higher doses of nicotine patch may produce small increases in quit rates. Only one study directly compared NRT to another pharmacotherapy. In this study quit ...
Nicotine replacement therapy as a smoking cessation tool ...
While NRT can reduce smoking and alleviate withdrawal symptoms, its effectiveness in sustaining long-term cessation in adolescents is limited.
Efficacy of a nicotine mouth spray in smoking cessation
Unpublished results from a craving relief study demonstrate that two doses of NMS 1 mg reduced craving significantly faster than either nicotine lozenge 2 mg or ...
5.
evidence.nihr.ac.uk
evidence.nihr.ac.uk/alert/using-both-nicotine-patches-and-gum-together-improves-the-chances-of-quitting-smoking/Using both nicotine patches and gum together improves ...
Using a nicotine patch together with a fast-acting type of nicotine replacement therapy (NRT) such as gum or lozenges improves smoking cessation rates.
6.
cancer.org
cancer.org/cancer/risk-prevention/tobacco/guide-quitting-smoking/nicotine-replacement-therapy.htmlNicotine Replacement Therapy to Help You Quit Tobacco
Many studies have shown using NRT can almost double the chances of quitting smoking. It hasn't been studied as much for quitting smokeless ...
7.
tobaccoinduceddiseases.org
tobaccoinduceddiseases.org/Adverse-events-associated-with-nicotine-replacement-therapy-NRT-for-smoking-cessation,65973,0,2.htmlAdverse events associated with nicotine replacement ...
Nicotine replacement therapy (NRT) is the most common form of smoking cessation pharmacotherapy and has proven efficacy for the treatment of tobacco dependence.
How to Combine Quit Smoking Medicines
Using two nicotine replacement medicines (NRTs) together is more likely to help you quit successfully than using one alone. Patch will reduce your withdrawal ...
Adverse events associated with nicotine replacement therapy ...
This review demonstrates that NRT is associated with adverse effects that may be discomforting for the patient but are not life-threatening. Given the long-term ...
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