Trinalin

Treatment

0 Active Studies for Trinalin

What is Trinalin

AzatadineThe Generic name of this drug

Treatment SummaryPseudoephedrine is a drug found in the ephedra plant, which has been used in Eastern medicine for centuries. It is related to ephedrine, but is much weaker in its effects on the nervous system. Pseudoephedrine was first studied in the West in 1889 and was discovered to have a decongestant effect on dogs in 1927.

Trinalin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Azatadine

Effectiveness

How Trinalin Affects PatientsPseudoephedrine can help reduce congestion by narrowing the blood vessels. It usually works quickly, but if taken in extended-release form the effects last longer. Patients should be aware that it can cause stimulation of the central nervous system.

How Trinalin works in the bodyPseudoephedrine is a drug that works by activating certain receptors in the body. It tightens blood vessels, making it useful for relieving congestion, and can help treat priapism. It also blocks the action of certain neurotransmitters, like norepinephrine and dopamine, and prevents certain proteins from turning on. These effects cause an increase in blood pressure and heart rate, and can help relax the muscles of the rectum.

Warnings

Trinalin has five contraindications, thus it should not be merged with any of the disorders indicated in the table below.There are 20 known major drug interactions with Trinalin.

Common Trinalin Drug Interactions

Drug Name

Risk Level

Description

Capmatinib

Major

The serum concentration of Capmatinib can be decreased when it is combined with Azatadine.

Hydroxyzine

Major

The risk or severity of QTc prolongation can be increased when Azatadine is combined with Hydroxyzine.

Mobocertinib

Major

The risk or severity of QTc prolongation can be increased when Azatadine is combined with Mobocertinib.

Pitolisant

Major

The therapeutic efficacy of Pitolisant can be decreased when used in combination with Azatadine.

Rimegepant

Major

The metabolism of Rimegepant can be increased when combined with Azatadine.

Trinalin Toxicity & Overdose RiskThe lowest toxic dose of pseudoephedrine in rats is 2206mg/kg and 726mg/kg in mice. Symptoms of an overdose may include dizziness, headache, nausea, vomiting, sweating, thirst, rapid heartbeat, chest pain, difficulty urinating, muscle weakness, anxiety, restlessness, insomnia, psychosis, abnormal heart rhythms, shock, seizures, unconsciousness, and difficulty breathing. To treat an overdose, remove any unabsorbed drug and provide supportive care.

image of a doctor in a lab doing drug, clinical research

Trinalin Reviews: What are patients saying about Trinalin?

5Patient Review

10/5/2007

Trinalin for Inflammation of the Nose due to an Allergy

In Canada, this medication has been discontinued. Are there any good substitutes out there?

Patient Q&A Section about trinalin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does pseudoephedrine reduce nasal congestion?

"The drug pseudoephedrine constricts blood vessels not just in the nose and sinuses, but throughout the entire body, which can have the effect of shrinking swelling and draining fluids so that breathing becomes easier."

Answered by AI

What is Trinalin used for?

"Azatadine and pseudoephedrine are used together to treat symptoms such as sneezing, itching, watery eyes, and a runny nose that are caused by allergies or the common cold."

Answered by AI

What does pseudoephedrine do?

"Pseudoephedrine is a decongestant that can relieve a blocked or stuffy nose, which is caused by swollen blood vessels in the cavities in your nose (sinuses)."

Answered by AI