600 Participants Needed

Early Start Denver Model for Autism

AS
SD
Overseen BySarah Dufek, PhD
Age: Any Age
Sex: Any
Trial Phase: Academic
Sponsor: University of California, Davis
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the Early Start Denver Model (ESDM) to evaluate its effectiveness for young autistic children in various community settings. ESDM is a play-based therapy involving parents and emphasizing positive interactions. The trial will compare ESDM with standard treatments provided by community agencies. It suits children aged 1-5 with an autism diagnosis or those considered at risk, who will participate in therapy for at least 7 months. As an unphased trial, this study provides a unique opportunity to understand how ESDM can be effectively implemented in diverse community settings.

Will I have to stop taking my current medications?

The trial information does not specify whether participants need to stop taking their current medications.

What prior data suggests that the Early Start Denver Model (ESDM) is safe for young autistic children?

Research has shown that the Early Start Denver Model (ESDM) is generally well-received by young autistic children. In past studies, children participating in ESDM demonstrated improvements in communication, daily living skills, and thinking abilities over time. Reports indicate that children in ESDM programs often experience significant developmental benefits without major negative effects.

The ESDM uses several methods, including applied behavior analysis (ABA), which is already common in autism care, suggesting its safety. Additionally, caregiver involvement helps monitor potential issues and allows for adjustments if needed.

Overall, no strong evidence of safety problems with ESDM exists. It appears to be a promising and safe approach for early autism intervention.12345

Why are researchers excited about this trial?

Researchers are excited about the Early Start Denver Model (ESDM) for autism because it combines several unique elements into one comprehensive approach. Unlike traditional methods, ESDM integrates naturalistic applied behavior analysis (ABA) with relationship-based, developmental, and play-based techniques, making it more adaptable to a child's everyday activities. This model also emphasizes caregiver involvement by equipping them with coaching strategies to support their child's development at home. The hope is that by focusing on interpersonal exchanges and positive interactions, ESDM can lead to more meaningful, long-term improvements in social and communication skills for children with autism.

What evidence suggests that the Early Start Denver Model (ESDM) is effective for autism?

Research has shown that the Early Start Denver Model (ESDM), which participants in this trial may receive, holds promise for helping young autistic children. Studies have found that ESDM improves overall development, including language and social skills, more effectively than traditional treatments. Specifically, children who received ESDM demonstrated better thinking and learning abilities after two years in the program. The model uses natural interactions and play to engage children, enhancing their learning experiences. Involving caregivers is also a key part of ESDM, further supporting the child's progress. This evidence suggests that ESDM is an effective early intervention approach for autism.12678

Who Is on the Research Team?

AC

Aubyn C Stahmer, PhD

Principal Investigator

UC Davis

Are You a Good Fit for This Trial?

This trial is for young children aged 1-5 with autism or at risk for ASD, who haven't had ESDM training and will be in therapy for at least 7 months. Agencies must serve at least 10 such children annually, accept Medicaid, and have staff willing to participate for over a year.

Inclusion Criteria

My child, aged 1-5, has autism and lives in the US under care.
I am a program supervisor for children under 5 with autism, plan to work for the next year, haven't had ESDM training, and supervise at least two technicians.
Investigators will collect data from leaders, providers, and clients in participating autism CBAs
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive the Early Start Denver Model (ESDM) intervention, focusing on improving social communication and language outcomes in young autistic children.

12 months
Monthly caregiver coaching sessions

Follow-up

Participants are monitored for effectiveness and caregiver engagement after the treatment phase.

6 months
Quarterly assessments

What Are the Treatments Tested in This Trial?

Interventions

  • Early Intensive Behavioral Intervention (EIBI)
  • Early Start Denver Model (ESDM)
Trial Overview The study examines the Early Start Denver Model (ESDM) used by community agencies serving autistic children. It aims to assess how practical and effective ESDM is compared to Early Intensive Behavioral Intervention (EIBI) in real-world settings.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Active Control
Group I: Early Start Denver Model (ESDM)Experimental Treatment1 Intervention
Group II: Treatment as Usual (TAU)Active Control1 Intervention

Early Intensive Behavioral Intervention (EIBI) is already approved in United States, European Union for the following indications:

🇺🇸
Approved in United States as Early Start Denver Model for:
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Approved in European Union as Early Start Denver Model for:

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of California, Davis

Lead Sponsor

Trials
958
Recruited
4,816,000+

National Institute of Mental Health (NIMH)

Collaborator

Trials
3,007
Recruited
2,852,000+

Published Research Related to This Trial

The two-tiered Parent Early Start Denver Model (P-ESDM) intervention showed that all participating parents improved their use of ESDM strategies after group coaching, indicating the effectiveness of parent-led interventions for young autistic children.
Children exhibited positive changes in engagement, imitation, and communication skills, with significant relationships found between how well parents implemented ESDM strategies and the children's developmental outcomes.
Evaluating a Two-Tiered Parent Coaching Intervention for Young Autistic Children Using the Early Start Denver Model.van Noorden, LE., Sigafoos, J., Waddington, HL.[2022]
A prospective observational study involving 19 toddlers with Autism Spectrum Disorder (ASD) showed significant improvements in cognitive skills after 10 months of Early Start Denver Model (ESDM) intervention, particularly in receptive language development, which improved by an average of 19.6 points.
The study suggests that ESDM, delivered for 12 hours per week by a multidisciplinary team, can lead to positive outcomes in cognitive and adaptive behavior skills in toddlers with ASD, indicating a potential need for longer therapy duration to maximize benefits.
Using ESDM 12 hours per week in children with autism spectrum disorder: feasibility and results of an observational study.Geoffray, MM., Denis, A., Mengarelli, F., et al.[2019]
The Early Start Denver Model (ESDM) intervention, applied to 27 young children with autism spectrum disorder (ASD) in Japan, showed significant improvements in language and social development after an average of 8 months of treatment.
Participants also exhibited reduced severity of maladaptive behaviors and impairments in social interaction and communication, indicating that ESDM could be a standard treatment option for children with ASD in community settings.
The Efficacy of Early Start Denver Model Intervention in Young Children with Autism Spectrum Disorder Within Japan: A Preliminary Study.Tateno, Y., Kumagai, K., Monden, R., et al.[2022]

Citations

Early Start Denver Model effectiveness in young autistic ...To assess the effectiveness of ESDM compared with treatment as usual (TAU) on overall development in young children with autism spectrum disorder (ASD).
Examining the Effectiveness of the Early Start Denver ...This study tests the effectiveness of the Early Start Denver Model (ESDM) in community agencies that serve young autistic children.
Distinct Patterns of Cognitive Outcome in Young Children ...In this study, we analyze developmental trajectories of preschoolers with autism who received 2 years of intervention using the Early Start Denver Model (ESDM) ...
Clinical outcomes of an early intervention program for ...Start Denver Model (ESDM), can positively affect key outcomes for children with Autism Spectrum Disorder (ASD). However, programs involving ...
5.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/40473417/
Early Start Denver Model effectiveness in young autistic ...Objective: To assess the effectiveness of ESDM compared with treatment as usual (TAU) on overall development in young children with autism ...
ESDM Research and Outcomes in AutismThe parent-implemented Early Start Denver Model (P-ESDM) has shown positive child-parent-related outcomes in research published between 2012 and ...
Feasibility and Outcomes of the Early Start Denver Model ...The authors find moderate and significant improvement for ESDM-treated children compared to control groups, especially in cognition and language ...
Early Start Denver ModelData were collected at baseline and after one year of the ESDM intervention. Results showed improvements in communication skills, adaptive behavior, and ASD ...
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