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Targeted Radiation Therapy for Brain Cancer (RAPPLE Trial)
RAPPLE Trial Summary
This trial is testing a new, more targeted form of radiation therapy against the standard form of radiation therapy to see if it is just as effective in treating brain metastases.
RAPPLE Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.RAPPLE Trial Design
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Who is running the clinical trial?
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- My cancer has spread to the lining of my brain and spinal cord.I have had epilepsy or seizures but am not on seizure medication now.My doctor thinks I won't live long enough for surgery to help.My cancer is not related to blood cells.All my brain tumors can be clearly identified and targeted for treatment.I have not had whole brain radiotherapy in the last 6 months.I am scheduled for immunotherapy, targeted therapy, or hormone therapy after radiation.My neurological condition is worsening even with steroid treatment.I have not had brain surgery in the last 3 months.I have cancer that has spread to my brain.I can care for myself but may not be able to do active work.I am of childbearing age and not using effective birth control.I have multiple sclerosis.I am willing and able to attend regular imaging appointments.My brain cancer prognosis score is 2.0 or less.My kidney function, measured by eGFR, is above 30 ml/min.My cancer has spread outside of my brain.I am 18 years old or older.I need surgery to reduce pressure inside my skull.My lupus, scleroderma, or similar condition is not in remission.
- Group 1: 20 Gy in 5 Fractions Volumetric Modulated Arc Therapy to Brain Metastases
- Group 2: 8 Gy in 1 Fraction Volumetric Modulated Arc Therapy to Brain Metastases
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What health risks have been identified with Targeting All Brain Metastases?
"Our experts at Power have judged the safety of Targeting All Brain Metastases to be a 2, due to this being a Phase 2 trial. This implies that there is data in support of its security, yet no proof that it actually works as intended."
How many participants can join this examination?
"Affirmative. According to clinicaltrials.gov, this medical experiment is presently enlisting patients who meet the eligibility criteria. It was first advertised on July 1st 2022 and updated as recently as October 1 of the same year; it aims to recruit 100 participants from a single site."
To what demographic is this research opportunity available?
"Patient recruitment for this trial is seeking to enrol 100 individuals, aged 18 or above and below the age of 65, who have been diagnosed with neoplasm metastasis. Additionally, those accepted must possess a DS-GPA ≤ 2.0; brain tumours that can be contoured and targeted; an expected median survival time too short for surgery/stereotactic radiosurgery; a willingness to partake in regular imaging follow up sessions; as well as any size of extracranial disease."
Is the age qualification for this trial less than seventy-five years old?
"According to the study's eligibility requirements, the minimum age for participation is 18 and seniors up to 100 years old are able to join."
Are there any opportunities for volunteers to join this research project?
"Affirmative. The clinical trial's entry on clinicialtrials.gov reveals that the study, which was initially posted on July 1st 2022, is actively recruiting volunteers. There are one hundred participants needed from a single research centre to complete this investigation."
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