Targeted Radiation Therapy for Brain Cancer
(RAPPLE Trial)
Trial Summary
What is the purpose of this trial?
The aim of the study is to show that rapid, simple targeted radiotherapy to brain metastases with 8 Gy / 1 is non-inferior to 20 Gy / 5 in terms of overall survival for patients with poor prognosis.
Will I have to stop taking my current medications?
The trial protocol does not specify whether you need to stop taking your current medications. However, if you are on immunotherapy, targeted therapy, or hormone therapy, you cannot participate in the trial.
What data supports the effectiveness of the treatment RAPPLE for brain cancer?
Research shows that combining targeted therapies with stereotactic radiosurgery (a precise form of radiation therapy) can improve outcomes for brain metastases, which are common in brain cancer. This suggests that targeted radiation treatments like RAPPLE might be effective by leveraging similar principles.12345
Is targeted radiation therapy for brain cancer safe for humans?
How is the RAPid SimPLE Targeted Radiation Treatment (RAPPLE) different from other brain cancer treatments?
Research Team
Alan Nichol, MD
Principal Investigator
BC Cancer Vancouver
Eligibility Criteria
This trial is for adults with non-blood related cancers that have spread to the brain. Participants should have multiple brain tumors that can be targeted, a life expectancy not suitable for surgery or precise radiotherapy, and some active cancer outside the brain. They must also be able to complete questionnaires, follow up with imaging tests, start treatment within two weeks of joining, and have a performance score indicating they are still somewhat active.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either a single treatment of 8 Gy or five treatments of 4 Gy using volumetric modulated arc therapy to brain metastases
Follow-up
Participants are monitored for survival, control of brain disease, adverse events, and quality of life
Treatment Details
Interventions
- RAPid SimPLE Targeted Radiation Treatment
RAPid SimPLE Targeted Radiation Treatment is already approved in European Union, United States for the following indications:
- Brain metastases
- Brain metastases
Find a Clinic Near You
Who Is Running the Clinical Trial?
British Columbia Cancer Agency
Lead Sponsor
Varian Medical Systems
Industry Sponsor
Dow R. Wilson
Varian Medical Systems
Chief Executive Officer since 2012
MBA from Dartmouth's Amos Tuck School of Business, BA from Brigham Young University
Dr. Deepak Khuntia
Varian Medical Systems
Chief Medical Officer since 2020
MD from the University of Cambridge, PhD from the University of Leicester