Targeting All Brain Metastases for Brain Metastases

BC Cancer - Vancouver, Vancouver, Canada
Brain MetastasesTargeting All Brain Metastases - Radiation
Eligibility
18 - 100
All Sexes
What conditions do you have?
Select

Study Summary

This trial is testing a new, more targeted form of radiation therapy against the standard form of radiation therapy to see if it is just as effective in treating brain metastases.

Eligible Conditions
  • Brain Metastases

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 2

Study Objectives

1 Primary · 7 Secondary · Reporting Duration: 1 year

1 year
Adverse Events
Control of brain disease
Control of treated brain metastases
Health-Related Quality of Life
Median Time to Decline in Karnofsky Performance Status
Retreatments for brain metastases
Survival Time
6 weeks
Corticosteroid use

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

20 Gy in 5 Fractions Volumetric Modulated Arc Therapy to Brain Metastases
1 of 2
8 Gy in 1 Fraction Volumetric Modulated Arc Therapy to Brain Metastases
1 of 2

Active Control

Experimental Treatment

100 Total Participants · 2 Treatment Groups

Primary Treatment: Targeting All Brain Metastases · No Placebo Group · Phase 2

8 Gy in 1 Fraction Volumetric Modulated Arc Therapy to Brain Metastases
Radiation
Experimental Group · 1 Intervention: Targeting All Brain Metastases · Intervention Types: Radiation
20 Gy in 5 Fractions Volumetric Modulated Arc Therapy to Brain Metastases
Radiation
ActiveComparator Group · 1 Intervention: Targeting All Brain Metastases · Intervention Types: Radiation

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year

Who is running the clinical trial?

British Columbia Cancer AgencyLead Sponsor
166 Previous Clinical Trials
90,446 Total Patients Enrolled
Varian Medical SystemsIndustry Sponsor
47 Previous Clinical Trials
3,362 Total Patients Enrolled
Alan Nichol, MDPrincipal InvestigatorBC Cancer Vancouver
2 Previous Clinical Trials
5,518 Total Patients Enrolled

Eligibility Criteria

Age 18 - 100 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have cancer that has spread beyond the brain.
You are willing to have regular medical imaging tests.

Frequently Asked Questions

What health risks have been identified with Targeting All Brain Metastases?

"Our experts at Power have judged the safety of Targeting All Brain Metastases to be a 2, due to this being a Phase 2 trial. This implies that there is data in support of its security, yet no proof that it actually works as intended." - Anonymous Online Contributor

Unverified Answer

How many participants can join this examination?

"Affirmative. According to clinicaltrials.gov, this medical experiment is presently enlisting patients who meet the eligibility criteria. It was first advertised on July 1st 2022 and updated as recently as October 1 of the same year; it aims to recruit 100 participants from a single site." - Anonymous Online Contributor

Unverified Answer

To what demographic is this research opportunity available?

"Patient recruitment for this trial is seeking to enrol 100 individuals, aged 18 or above and below the age of 65, who have been diagnosed with neoplasm metastasis. Additionally, those accepted must possess a DS-GPA ≤ 2.0; brain tumours that can be contoured and targeted; an expected median survival time too short for surgery/stereotactic radiosurgery; a willingness to partake in regular imaging follow up sessions; as well as any size of extracranial disease." - Anonymous Online Contributor

Unverified Answer

Is the age qualification for this trial less than seventy-five years old?

"According to the study's eligibility requirements, the minimum age for participation is 18 and seniors up to 100 years old are able to join." - Anonymous Online Contributor

Unverified Answer

Are there any opportunities for volunteers to join this research project?

"Affirmative. The clinical trial's entry on clinicialtrials.gov reveals that the study, which was initially posted on July 1st 2022, is actively recruiting volunteers. There are one hundred participants needed from a single research centre to complete this investigation." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.