Dinaciclib for Advanced Melanoma
What You Need to Know Before You Apply
What is the purpose of this trial?
This phase II trial is studying the side effects and how well dinaciclib works in treating patients with stage IV melanoma. Dinaciclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Will I have to stop taking my current medications?
The trial requires that you do not take any other treatments like chemotherapy, hormonal therapy, or biologic therapy while participating. You also cannot take medications that affect the CYP3A4 enzyme, and you must avoid grapefruit and grapefruit juice.
How is the drug Dinaciclib unique in treating advanced melanoma?
Who Is on the Research Team?
Christopher D Lao
Principal Investigator
SWOG Cancer Research Network
Are You a Good Fit for This Trial?
This trial is for adults with stage IV melanoma who've had no more than one prior systemic treatment and have recovered from its side effects. They must not be pregnant or nursing, use effective contraception, and can't have brain metastases or ocular melanoma. Participants should not consume grapefruit, take certain other drugs, or have another cancer unless in remission for 5 years.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients receive dinaciclib IV over 2 hours on day 1, with treatment repeating every 21 days in the absence of disease progression or unacceptable toxicity
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Dinaciclib
Find a Clinic Near You
Who Is Running the Clinical Trial?
National Cancer Institute (NCI)
Lead Sponsor