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Lisinopril for Preventing Urinary Side Effects in Prostate Cancer Radiotherapy

Phase < 1
Recruiting
Research Sponsored by University of Rochester
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be stage M0 based on the standard of care staging imaging
Have a confirmed diagnosis of adenocarcinoma of the prostate and are candidates for curative-intent external beam radiation at the Wilmot Cancer Institute Department of Radiation Oncology
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Study Summary

This trial will help determine the best dose of lisinopril for men with prostate cancer undergoing radiation, and whether the drug can help relieve urinary symptoms.

Who is the study for?
Men under 70 with non-metastatic prostate cancer who are set for radiation therapy at Wilmot Cancer Institute can join. They must be in good health, able to follow the study plan, have normal kidney and liver function, not have had pelvic radiotherapy before, and not be on lisinopril or similar drugs recently.Check my eligibility
What is being tested?
The trial is testing different doses of Lisinopril tablets to find the best one for preventing urinary problems after radiation treatment for prostate cancer. It will also look at how Lisinopril affects certain biomarkers related to these urinary symptoms.See study design
What are the potential side effects?
Lisinopril may cause side effects like coughing, dizziness due to low blood pressure, headaches, fatigue, nausea or problems with kidney function. Some people might experience allergic reactions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My cancer has not spread to distant parts of my body.
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I have prostate cancer and am eligible for radiation therapy aimed at curing it.
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I am between 18 and 70 years old.
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My kidneys are working well, with a creatinine clearance over 30 mL/min.
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My blood and liver tests meet the required levels for treatment.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean change in Expanded Prostate Index Composite score
change in the percentage of patients with positive blood test in urine
percentage of participants who achieve a dose of 20 mg

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Intervention groupExperimental Treatment1 Intervention
Group II: Control groupActive Control1 Intervention
Patients who receive radiation but no intervention

Find a Location

Who is running the clinical trial?

University of RochesterLead Sponsor
834 Previous Clinical Trials
518,262 Total Patients Enrolled
7 Trials studying Prostate Cancer
527 Patients Enrolled for Prostate Cancer
Medical College of WisconsinOTHER
608 Previous Clinical Trials
1,162,481 Total Patients Enrolled
7 Trials studying Prostate Cancer
8,427 Patients Enrolled for Prostate Cancer

Media Library

Lisinopril Tablets Clinical Trial Eligibility Overview. Trial Name: NCT05530655 — Phase < 1
Prostate Cancer Research Study Groups: Control group, Intervention group
Prostate Cancer Clinical Trial 2023: Lisinopril Tablets Highlights & Side Effects. Trial Name: NCT05530655 — Phase < 1
Lisinopril Tablets 2023 Treatment Timeline for Medical Study. Trial Name: NCT05530655 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research continuing to accept participants?

"The clinicaltrials.gov information reveals that this particular medical trial is not currently seeking new participants, as the last update was on September 1st 2022 and it was initially posted January 15th 2023. Nevertheless, there are presently 1340 other trials actively recruiting patients."

Answered by AI

Does this research encompass individuals who are over 40 years of age?

"This medical experiment is exclusively available to those between 18 and 70 years of age. In contrast, younger patients have access to 77 trials while elders can find 1334 opportunities for clinical trial participation."

Answered by AI

To what demographic is this research open?

"This clinical trial is acquiescing seventy individuals diagnosed with prostate cancer, aged between 18 and 70. Crucially, they must meet the following criteria: a definitive diagnosis of adenocarcinoma of the prostate (and be candidates for curative-intent external beam radiation), proficiency in English reading, systolic blood pressure higher than 130mmHg at baseline, M0 stage according to standard imaging procedures within 180 days prior to enrollment, ECOG performance status from 0 to 2 before registration, creatinine clearance exceeding 30mL/min beforehand; hemoglobin level of 9.0 g/dL or more without transfusions nor growth"

Answered by AI
~20 spots leftby Jan 2026