Cosopt

Migraine, Open-angle glaucoma, prophylaxis of migraine headaches + 6 more

Treatment

20 Active Studies for Cosopt

Treatment for

Migraine

What is Cosopt

TimololThe Generic name of this drug

Treatment SummaryDorzolamide is a medication used to treat eye conditions such as open-angle glaucoma and ocular hypertension. It works by blocking an enzyme that helps regulate the fluid pressure and ion balance in the eyes. Unlike oral carbonic anhydrase inhibitors, Dorzolamide has minimal effects on acid-base and electrolyte levels, as well as few systemic side effects. It was first released in 1995 and is available as both a stand-alone drug (Trusopt) and a combination drug with Timolol (Cosopt PF).

Timopticis the brand name

Cosopt Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Timoptic

Timolol

1978

167

Effectiveness

How Cosopt Affects PatientsDorzolamide is a medication that lowers pressure in the eye. It is used to treat open-angle glaucoma or ocular hypertension. When combined with other eye medications, Dorzolamide can have a stronger effect on reducing pressure in the eye. This medicine usually starts working within two hours after it is used.

How Cosopt works in the bodyDorzolamide is used to treat ocular hypertension and glaucoma. It works by reducing the amount of fluid produced in the eye, which lowers the intraocular pressure. This drug specifically targets an enzyme called Carbonic Anhydrase II which helps produce bicarbonate ions in the ciliary process of the eye. By inhibiting this enzyme, Dorzolamide reduces sodium and fluid transport, resulting in less fluid and lower intraocular pressure. When intraocular pressure is reduced, it prevents blood flow restrictions and keeps the optic nerve from getting damaged, which would cause vision loss.

When to interrupt dosage

The suggested dosage of Cosopt is contingent upon the diagnosed condition, such as neodynium yttrium aluminum garnet laser posterior capsulotomy, Ocular Hypertension and Increased Intra Ocular Pressure (IOP). The dosage is a function of the administration method (e.g. Solution - Ophthalmic or Solution / drops) outlined in the table below.

Condition

Dosage

Administration

insufficient response to beta-blockers

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic

Migraine

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

Open-angle glaucoma

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

Ocular Hypertension

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

inadequate response to other therapeutic measures

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

prophylaxis of migraine headaches

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

Open Angle Glaucoma

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

requiring adjunctive or replacement therapy

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

Increased Intra Ocular Pressure (IOP)

5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL

Warnings

Cosopt Contraindications

Condition

Risk Level

Notes

Lung Diseases, Obstructive

Do Not Combine

Sinus Bradycardia

Do Not Combine

Shock, Cardiogenic

Do Not Combine

second or third degree AV block

Do Not Combine

Asthma

Do Not Combine

overt cardiac failure

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Timolol may interact with Pulse Frequency

There are 20 known major drug interactions with Cosopt.

Common Cosopt Drug Interactions

Drug Name

Risk Level

Description

4-Bromo-2,5-dimethoxyphenethylamine

Major

The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Timolol.

4-Methoxyamphetamine

Major

The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Timolol.

Abediterol

Major

Timolol may decrease the bronchodilatory activities of Abediterol.

Adrafinil

Major

The therapeutic efficacy of Adrafinil can be decreased when used in combination with Timolol.

Agrostis gigantea pollen

Major

The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Timolol.

Cosopt Toxicity & Overdose RiskThe lowest toxic dose of dorzolamide in rats is 1927mg/kg and 1320mg/kg in mice, when taken orally. In the event of an overdose, patients may experience electrolyte imbalances, acidosis, and changes in the central nervous system. Appropriate care should be taken and the patient’s potassium and pH levels should be monitored.

image of a doctor in a lab doing drug, clinical research

Cosopt Novel Uses: Which Conditions Have a Clinical Trial Featuring Cosopt?

34 active clinical trials are currently underway to assess the potential of Cosopt in providing relief for Ocular Hypertension, Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma.

Condition

Clinical Trials

Trial Phases

Increased Intra Ocular Pressure (IOP)

0 Actively Recruiting

Open-angle glaucoma

84 Actively Recruiting

Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1

prophylaxis of migraine headaches

0 Actively Recruiting

requiring adjunctive or replacement therapy

0 Actively Recruiting

Migraine

52 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

inadequate response to other therapeutic measures

0 Actively Recruiting

insufficient response to beta-blockers

0 Actively Recruiting

Ocular Hypertension

22 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4

Open Angle Glaucoma

12 Actively Recruiting

Not Applicable, Phase 3, Phase 2

Cosopt Reviews: What are patients saying about Cosopt?

5Patient Review

11/27/2009

Cosopt for Increased Pressure in the Eye

This medication was prescribed to me by my optometrist when my eye pressure readings suddenly skyrocketed. Within a week and a half, it had dropped back down to the normal range. I've been using it regularly since then with no issues.

5Patient Review

4/6/2013

Cosopt for Increased Pressure in the Eye

I experienced some leg pain while taking this medication.

5Patient Review

7/15/2014

Cosopt for Wide-Angle Glaucoma

The drops caused my eyes to burn.

5Patient Review

1/16/2010

Cosopt for Increased Pressure in the Eye

I've been using this product for a few years now and have always been really pleased with the results.

4Patient Review

1/20/2009

Cosopt for Increased Pressure in the Eye

Blurred vision is a very annoying side effect. I spent a lot of money on medical testing for tia's but I feel the blurred vision was from the medication.

3.7Patient Review

11/23/2008

Cosopt for Wide-Angle Glaucoma

Although this product has helped lower my eye pressure, I have noticed that my eyesight has gotten worse since using it.

3.3Patient Review

8/20/2011

Cosopt for Wide-Angle Glaucoma

I stopped using Cosorpt for a few days and my back pain improved, which leads me to believe that the medicine was causing the issue in the first place. I had been taking it for years without realizing the potential consequences.

3.3Patient Review

2/11/2014

Cosopt for Wide-Angle Glaucoma

Xalatan did help lower my eye pressure, which was in the upper 20s, but after adding Cosopt per my doctor's orders, I've seen even better results. My pressure is now down to 18. The only side effects I've experienced are occasional and mild; they include a stinging sensation in my eyes for a few moments post-application as well as a bitter taste at the back of my throat.

3Patient Review

11/17/2008

Cosopt for Wide-Angle Glaucoma

There are times when I really don't like using cosopt because the blurred vision is so bad. It seems to be worse when I'm physically active.

3Patient Review

6/24/2022

Cosopt for Wide-Angle Glaucoma

The medication works well, but the plastic containers are garbage. Sometimes you get all the contents in the first eye and nothing is left for the second. The current lot that I have is impossible to twist off; I have to cut it off. I've requested that my doctor prescribe Cosopt in a different container, but he wants me to stick with Pf

3Patient Review

5/26/2010

Cosopt for Increased Pressure in the Eye

I unfortunately had a really negative reaction to these eyedrops. I got migraines, intense eye pain, high blood pressure, and felt very confused.

3Patient Review

1/17/2021

Cosopt for Increased Pressure in the Eye

I'm experiencing a lot of tearing and itching. Unfortunately, this is the second time I've had to use this medication and I'm having the same side effects.

2.7Patient Review

1/6/2009

Cosopt for Increased Pressure in the Eye

The medication has been successful in reducing my pressure, but the side effect of blurred vision is tough to deal with.

2Patient Review

4/5/2018

Cosopt for Increased Pressure in the Eye

The individual plastic packs are difficult to use. If you squeeze too hard all liquid comes in one drop; too soft the liquid gathers into one drop. Some vials had No liquid at all. The fear of losing out an application with each use is not worth the risk.

2Patient Review

12/8/2007

Cosopt for Increased Pressure in the Eye

1.3Patient Review

2/5/2019

Cosopt for Increased Pressure in the Eye

The container is not designed well. It's too hard to open, and sometimes the liquid squirts out when you try to twist off the top. Plus, it stings a lot when you put in the drops, which makes me feel faint. I don't know yet how well it works in terms of lowering my blood pressure readings. But based on the packaging alone, this medication is overpriced and not worth it.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cosopt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is Cosopt?

"COSOPT contains two different types of medicine: dorzolamide hydrochloride, an ophthalmic carbonic anhydrase inhibitor, and timolol maleate, a beta-blocker."

Answered by AI

What are the side effects of cosopt PF eye drops?

"If you experience any of the following side effects, tell your doctor or pharmacist promptly: Temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, feeling as if something is in the eye, sensitivity of eyes to light, strange taste in the mouth, or headache."

Answered by AI

What is the generic name for Cosopt?

"Cosopt pairs the drug timolol with another medication, dorzolamide. Your doctor may prescribe this combination drug if timolol alone is not sufficiently treating your high eye pressure or glaucoma."

Answered by AI

What is Cosopt eye drops used for?

"COSOPT is a medication used to lower the pressure in the eye in the treatment of glaucoma. It is used when beta-blocker eyedrop medicine used alone is not adequate."

Answered by AI