Istalol

Migraine, Open-angle glaucoma, Migraine Disorders + 6 more
Treatment
20 Active Studies for Istalol

What is Istalol

TimololThe Generic name of this drug
Treatment SummaryTimolol is a medication used to reduce pressure in the eyes and treat high blood pressure. It is usually given as eye drops or taken orally as a tablet. Timolol was approved by the FDA in 1978 and is available from multiple manufacturers. It is a reliable and effective treatment for open-angle glaucoma and hypertension.
Timopticis the brand name
image of different drug pills on a surface
Istalol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Timoptic
Timolol
1978
167

Effectiveness

How Istalol Affects PatientsTimolol is a drug that can be administered in the form of eye drops or tablets. Eye drops cause a rapid decrease in intraocular pressure, and tablets reduce blood pressure, heart rate, and sympathetic activity. The effects of timolol usually take place within 20 minutes of the eye drops being administered, and can last up to 24 hours if the 0.5% or 0.25% doses are taken.
How Istalol works in the bodyTimolol works by blocking certain receptors in your body. It blocks receptors in your heart which help to regulate blood pressure and heart rate. It blocks receptors in your blood vessels, which makes it easier for your blood to flow and reduces your blood pressure. Finally, it also affects receptors in your eyes, which helps to reduce pressure in the eye. The exact way it works in the eye is still unknown, but it likely affects the flow of fluids in the eye, reducing pressure.

When to interrupt dosage

The measure of Istalol is contingent upon the diagnosed situation, such as Open Angle Glaucoma, necessitating adjunctive or replacement treatment and Ocular Hypertension. The dose varies in accordance with the technique of administration (e.g. Ophthalmic or Solution, gel forming/drops) presented in the table below.
Condition
Dosage
Administration
Migraine Disorders
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Open-angle glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Migraine
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
inadequate response to other therapeutic measures
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
insufficient response to beta-blockers
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
requiring adjunctive or replacement therapy
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Open Angle Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops
Ocular Hypertension
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
Ophthalmic, Solution - Ophthalmic, Solution, , Oral, Tablet, Tablet - Oral, Solution / drops - Ophthalmic, Solution / drops, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid - Ophthalmic, Liquid, Suspension / drops, Suspension / drops - Ophthalmic, Suspension - Ophthalmic, Suspension, Solution, gel forming / drops - Ophthalmic, Solution, gel forming / drops

Warnings

Istalol Contraindications
Condition
Risk Level
Notes
Lung Diseases, Obstructive
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Atrioventricular Block
Do Not Combine
Asthma
Do Not Combine
Heart Failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Timolol may interact with Pulse Frequency
There are 20 known major drug interactions with Istalol.
Common Istalol Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Timolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Timolol.
Abediterol
Major
Timolol may decrease the bronchodilatory activities of Abediterol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Timolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Timolol.
Istalol Toxicity & Overdose RiskThe toxic dose of timolol in rats is 1028mg/kg and 1137mg/kg in mice. Those who overdose on timolol may feel dizzy, have a headache, difficulty breathing, and a slower than normal heart rate. In extreme cases, an overdose of timolol can lead to cardiac arrest. Dialysis can be used to reverse the effects of an overdose, although it may not be as effective for those with kidney problems.
image of a doctor in a lab doing drug, clinical research

Istalol Novel Uses: Which Conditions Have a Clinical Trial Featuring Istalol?

172 active studies are presently investigating the potential of Istalol to provide a therapeutic benefit in cases of inadequate response to beta-blockers, other therapies, or necessitating adjunct or replacement therapy.
Condition
Clinical Trials
Trial Phases
Open-angle glaucoma
45 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 4, Early Phase 1, Phase 1
Open Angle Glaucoma
10 Actively Recruiting
Phase 3, Not Applicable, Phase 4
Ocular Hypertension
10 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4
requiring adjunctive or replacement therapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Migraine Disorders
1 Actively Recruiting
Phase 3
Migraine
51 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1
Glaucoma
0 Actively Recruiting
insufficient response to beta-blockers
0 Actively Recruiting

Istalol Reviews: What are patients saying about Istalol?

5Patient Review
12/11/2013
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
Istalol is very effective, but it's also quite expensive. I've been using it since 2004 with great results, so even though it's pricey, I feel like it's worth the investment to protect my eyesight.
5Patient Review
9/4/2013
Istalol for Closed Angle Glaucoma
This medicine was effective when others have failed.
5Patient Review
11/7/2007
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
5Patient Review
9/22/2008
Istalol for Closed Angle Glaucoma
4.7Patient Review
1/19/2010
Istalol for Wide-Angle Glaucoma
There's a fair amount of discomfort associated with this treatment, but it's worth it for the results.
4.3Patient Review
3/14/2013
Istalol for Wide-Angle Glaucoma
The only downside I've experienced is that my eyes have stayed swollen and irritated. They look broken out, especially above my eyelids and under my bottom eyelashes, from all the rubbing even though I know I shouldn't.
3.7Patient Review
10/19/2011
Istalol for Increased Pressure in the Eye
Since I began using Istalol Drops 9 weeks ago, I have experienced short-term burning and stinging sensations when first putting the drops in. About 4 weeks ago, my tongue started to feel sensitive and like it was being burned. The severity of these symptoms has continued to worsen until now my tongue feels raw and swollen. I am wondering if this is due to the Istalol since it is the only change I have had in medications or routine. My blood pressure has also increased. Has anyone else experienced these symtoms while on Istalol?
3.3Patient Review
10/9/2017
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I felt a burning sensation in both of my eyes when I first applied this medication. However, it dissipated after a few minutes. My doctor wants me to keep using the drops to see if they will help reduce the pressure in my eyes more than my original prescription. If the stinging continues or other symptoms develop, I will stop using them and go back to the original prescribed drops.
3Patient Review
10/21/2010
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I unfortunately experienced some pain after using this product. After a month or so of use, I also developed headaches and increased blood sugar levels. While it did help control my eye pressure, the other problems led me to discontinue use.
3Patient Review
5/25/2013
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I've been on this medication for a little over two years now. When I first started, my distance vision was still great and I could adjust my eyes from light to dark pretty quickly. However, now I've lost some of my distance vision and find myself more short of breath.
2.7Patient Review
3/6/2010
Istalol for Wide-Angle Glaucoma
The directions say not to squeeze the sides of the bottle, but due to my arthritis and carpel tunnel, this is the only way I can get the drops in my eyes. If it came with an eye dropper, that would be much easier.
2Patient Review
2/9/2009
Istalol for Increased Pressure in the Eye in the Absence of a Lens
The first dose of one drop just caused some itching. The next day the drop caused the itching and the tissue around the eye swelled up. It took a day and a half for the swelling to go down. The Dr has since changed my prescription.
1.7Patient Review
5/6/2011
Istalol for Closed Angle Glaucoma
Unfortunately, I had a really bad reaction to this medication. My eye started stinging shortly after using it and within a few hours my eye was swollen shut. If you have any history of allergies, I would recommend avoiding this treatment.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about istalol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Istalol used for?

"Istalol is a prescription medicine used to treat the symptoms of Ocular Hypertension. Istalol may be used alone or with other medications. Istalol belongs to a class of drugs called Antiglaucoma, Beta-Blockers. The safety and effectiveness of Istalol in children younger than 2 years of age is not known."

Answered by AI

How much does Istalol cost?

"Without insurance, Istalol costs $231.84. However, if you use a SingleCare Istalol coupon, you can pay only $51.94 for the same amount."

Answered by AI

What is the generic for Istalol?

"Ophthalmic timolol maleate is available in different strengths and forms, including 0.25% and 0.5% gel forming solutions and 0.25% and 0.5% solutions. These forms of timolol maleate have the same indications as Istalol."

Answered by AI

Is Istalol the same as timolol?

"The drugs Timoptic, Istalol, and Betimol all come as eye drops and contain the active drug ingredient timolol. However, Timoptic and Istalol both contain timolol maleate while Betimol contains timolol hemihydrate."

Answered by AI

Clinical Trials for Istalol

Image of Johns Hopkins Medicine in Baltimore, United States.

Embolization for Migraine

18 - 80
All Sexes
Baltimore, MD
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries. MMA embolization with Onyx is not approved for use in patients with migraines, but is currently used in patients with subdural hematomas. The FDA is allowing the use of Onyx in this study. It is thought that by using Onyx to block the middle meningeal arteries, the amount of migraine-causing substances which are released into the brain's bloodstream will be reduced. The company that manufactures Onyx, Medtronic, is providing the supplies for this study. Participants will be in the study for about 8 months after enrolling, including 6 months of follow up after the procedure. The participants will be asked to complete a daily headache diary and continue the participant's regular migraine medications. Participants will also have several clinic visits and be asked to provide blood samples for research.
Waitlist Available
Has No Placebo
Johns Hopkins MedicineRisheng Xu, MD, PhDMedtronic
Have you considered Istalol clinical trials? We made a collection of clinical trials featuring Istalol, we think they might fit your search criteria.Go to Trials
Have you considered Istalol clinical trials? We made a collection of clinical trials featuring Istalol, we think they might fit your search criteria.Go to Trials
Image of Mount Sinai Hospital in New York, United States.

Rimegepant + Zavegepant for Migraine

18+
All Sexes
New York, NY
This study evaluates the effectiveness of rimegepant 75 mg orally disintegrating tablet (ODT) single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments during Emergency Department (ED) encounters. Although these two calcitonin gene-related peptide receptors (CGRP) receptor antagonists are FDA-approved for the indication of acute migraine treatment, past studies have been limited to the outpatient setting. If these medications are effective in the Emergency Department, their delivery methods alone may have advantages over intravenous medications commonly used for acute migraine in EDs, including quicker time to treatment delivery, faster pain relief, and reduced ED length of stay. This investigation is a pilot study to examine rimegepant and zavegepant in an ED, to gain insight on effectiveness in this setting. This study will administer rimegepant 75 mg ODT single-dose or zavegepant 10 mg nasal spray single-dose as acute migraine treatments to 100 patients in the Emergency Department. It is a single center, open-label, non-controlled 2-group clinical trial (allocated 1:1 to rimegepant or zavegepant via pseudo-random assignment). The study will enroll adults in the ED meeting ICHD-3 criteria for migraine or probable migraine, with or without aura.
Phase 4
Recruiting
Mount Sinai HospitalJonathan SchimmelPfizer
Have you considered Istalol clinical trials? We made a collection of clinical trials featuring Istalol, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security