Istalol

Migraine, Open-angle glaucoma, prophylaxis of migraine headaches + 6 more
Treatment
20 Active Studies for Istalol

What is Istalol

TimololThe Generic name of this drug
Treatment SummaryTimolol is a medication used to reduce pressure in the eyes and treat high blood pressure. It is usually given as eye drops or taken orally as a tablet. Timolol was approved by the FDA in 1978 and is available from multiple manufacturers. It is a reliable and effective treatment for open-angle glaucoma and hypertension.
Timopticis the brand name
image of different drug pills on a surface
Istalol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Timoptic
Timolol
1978
167

Effectiveness

How Istalol Affects PatientsTimolol is a drug that can be administered in the form of eye drops or tablets. Eye drops cause a rapid decrease in intraocular pressure, and tablets reduce blood pressure, heart rate, and sympathetic activity. The effects of timolol usually take place within 20 minutes of the eye drops being administered, and can last up to 24 hours if the 0.5% or 0.25% doses are taken.
How Istalol works in the bodyTimolol works by blocking certain receptors in your body. It blocks receptors in your heart which help to regulate blood pressure and heart rate. It blocks receptors in your blood vessels, which makes it easier for your blood to flow and reduces your blood pressure. Finally, it also affects receptors in your eyes, which helps to reduce pressure in the eye. The exact way it works in the eye is still unknown, but it likely affects the flow of fluids in the eye, reducing pressure.

When to interrupt dosage

The measure of Istalol is contingent upon the diagnosed situation, such as Open Angle Glaucoma, necessitating adjunctive or replacement treatment and Ocular Hypertension. The dose varies in accordance with the technique of administration (e.g. Ophthalmic or Solution, gel forming/drops) presented in the table below.
Condition
Dosage
Administration
insufficient response to beta-blockers
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
inadequate response to other therapeutic measures
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Ocular Hypertension
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
prophylaxis of migraine headaches
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open Angle Glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
requiring adjunctive or replacement therapy
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Migraine
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Open-angle glaucoma
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic
Increased Intra Ocular Pressure (IOP)
5.0 mg/mL, , 5.0 mg, 10.0 mg, 20.0 mg, 2.5 mg/mL, 6.8 mg/mL, 6.83 mg/mL, 2.56 mg/mL, 5.12 mg/mL, 0.5 %, 0.25 %, 3.4 mg/mL, 0.1 mg/mL
, Ophthalmic, Solution, Solution - Ophthalmic, Oral, Tablet, Tablet - Oral, Solution / drops, Solution / drops - Ophthalmic, Solution, gel forming, extended release, Solution, gel forming, extended release - Ophthalmic, Liquid, Liquid - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Suspension, Suspension - Ophthalmic, Solution, gel forming / drops, Solution, gel forming / drops - Ophthalmic

Warnings

Istalol Contraindications
Condition
Risk Level
Notes
Lung Diseases, Obstructive
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
second or third degree AV block
Do Not Combine
Asthma
Do Not Combine
overt cardiac failure
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Timolol may interact with Pulse Frequency
There are 20 known major drug interactions with Istalol.
Common Istalol Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Timolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Timolol.
Abediterol
Major
Timolol may decrease the bronchodilatory activities of Abediterol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Timolol.
Agrostis gigantea pollen
Major
The risk of a hypersensitivity reaction to Agrostis gigantea pollen is increased when it is combined with Timolol.
Istalol Toxicity & Overdose RiskThe toxic dose of timolol in rats is 1028mg/kg and 1137mg/kg in mice. Those who overdose on timolol may feel dizzy, have a headache, difficulty breathing, and a slower than normal heart rate. In extreme cases, an overdose of timolol can lead to cardiac arrest. Dialysis can be used to reverse the effects of an overdose, although it may not be as effective for those with kidney problems.
image of a doctor in a lab doing drug, clinical research

Istalol Novel Uses: Which Conditions Have a Clinical Trial Featuring Istalol?

172 active studies are presently investigating the potential of Istalol to provide a therapeutic benefit in cases of inadequate response to beta-blockers, other therapies, or necessitating adjunct or replacement therapy.
Condition
Clinical Trials
Trial Phases
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
prophylaxis of migraine headaches
0 Actively Recruiting
Open-angle glaucoma
84 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1
requiring adjunctive or replacement therapy
0 Actively Recruiting
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
inadequate response to other therapeutic measures
0 Actively Recruiting
insufficient response to beta-blockers
0 Actively Recruiting
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Open Angle Glaucoma
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2

Istalol Reviews: What are patients saying about Istalol?

5Patient Review
12/11/2013
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
Istalol is very effective, but it's also quite expensive. I've been using it since 2004 with great results, so even though it's pricey, I feel like it's worth the investment to protect my eyesight.
5Patient Review
9/4/2013
Istalol for Closed Angle Glaucoma
This medicine was effective when others have failed.
5Patient Review
11/7/2007
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
5Patient Review
9/22/2008
Istalol for Closed Angle Glaucoma
4.7Patient Review
1/19/2010
Istalol for Wide-Angle Glaucoma
There's a fair amount of discomfort associated with this treatment, but it's worth it for the results.
4.3Patient Review
3/14/2013
Istalol for Wide-Angle Glaucoma
The only downside I've experienced is that my eyes have stayed swollen and irritated. They look broken out, especially above my eyelids and under my bottom eyelashes, from all the rubbing even though I know I shouldn't.
3.7Patient Review
10/19/2011
Istalol for Increased Pressure in the Eye
Since I began using Istalol Drops 9 weeks ago, I have experienced short-term burning and stinging sensations when first putting the drops in. About 4 weeks ago, my tongue started to feel sensitive and like it was being burned. The severity of these symptoms has continued to worsen until now my tongue feels raw and swollen. I am wondering if this is due to the Istalol since it is the only change I have had in medications or routine. My blood pressure has also increased. Has anyone else experienced these symtoms while on Istalol?
3.3Patient Review
10/9/2017
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I felt a burning sensation in both of my eyes when I first applied this medication. However, it dissipated after a few minutes. My doctor wants me to keep using the drops to see if they will help reduce the pressure in my eyes more than my original prescription. If the stinging continues or other symptoms develop, I will stop using them and go back to the original prescribed drops.
3Patient Review
10/21/2010
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I unfortunately experienced some pain after using this product. After a month or so of use, I also developed headaches and increased blood sugar levels. While it did help control my eye pressure, the other problems led me to discontinue use.
3Patient Review
5/25/2013
Istalol for High Eye Pressure or Glaucoma that May Worsen without Treatment
I've been on this medication for a little over two years now. When I first started, my distance vision was still great and I could adjust my eyes from light to dark pretty quickly. However, now I've lost some of my distance vision and find myself more short of breath.
2.7Patient Review
3/6/2010
Istalol for Wide-Angle Glaucoma
The directions say not to squeeze the sides of the bottle, but due to my arthritis and carpel tunnel, this is the only way I can get the drops in my eyes. If it came with an eye dropper, that would be much easier.
2Patient Review
2/9/2009
Istalol for Increased Pressure in the Eye in the Absence of a Lens
The first dose of one drop just caused some itching. The next day the drop caused the itching and the tissue around the eye swelled up. It took a day and a half for the swelling to go down. The Dr has since changed my prescription.
1.7Patient Review
5/6/2011
Istalol for Closed Angle Glaucoma
Unfortunately, I had a really bad reaction to this medication. My eye started stinging shortly after using it and within a few hours my eye was swollen shut. If you have any history of allergies, I would recommend avoiding this treatment.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about istalol

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Istalol used for?

"Istalol is a prescription medicine used to treat the symptoms of Ocular Hypertension. Istalol may be used alone or with other medications. Istalol belongs to a class of drugs called Antiglaucoma, Beta-Blockers. The safety and effectiveness of Istalol in children younger than 2 years of age is not known."

Answered by AI

How much does Istalol cost?

"Without insurance, Istalol costs $231.84. However, if you use a SingleCare Istalol coupon, you can pay only $51.94 for the same amount."

Answered by AI

What is the generic for Istalol?

"Ophthalmic timolol maleate is available in different strengths and forms, including 0.25% and 0.5% gel forming solutions and 0.25% and 0.5% solutions. These forms of timolol maleate have the same indications as Istalol."

Answered by AI

Is Istalol the same as timolol?

"The drugs Timoptic, Istalol, and Betimol all come as eye drops and contain the active drug ingredient timolol. However, Timoptic and Istalol both contain timolol maleate while Betimol contains timolol hemihydrate."

Answered by AI

Clinical Trials for Istalol

Have you considered Istalol clinical trials? We made a collection of clinical trials featuring Istalol, we think they might fit your search criteria.
Have you considered Istalol clinical trials? We made a collection of clinical trials featuring Istalol, we think they might fit your search criteria.
Have you considered Istalol clinical trials? We made a collection of clinical trials featuring Istalol, we think they might fit your search criteria.
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