Steroid-Enhanced Nerve Block for Uterine Fibroids Pain Relief
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of the study is to investigate the differences in post-procedural pain scores and narcotic use among patients who receive a Superior Hypogastric Nerve Block (SHNB) with and without corticosteroid performed as part of the Uterine Artery Embolization (UAE) procedure.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is the steroid-enhanced nerve block treatment generally safe for humans?
Bupivacaine (Marcaine), used in various forms of anesthesia, has been shown to be generally safe with minimal side effects when used in recommended doses. In a review of 11,080 cases, only 15 systemic toxic reactions occurred, all without lasting negative effects, indicating a good safety profile when used correctly.12345
How does the drug Bupivacaine differ from other treatments for uterine fibroids pain relief?
Bupivacaine is unique because it is a long-acting local anesthetic that provides pain relief by blocking nerve signals, and it is often used in epidural anesthesia with minimal side effects. This makes it different from other treatments for uterine fibroids, which may not focus on nerve block techniques for pain management.12346
What data supports the effectiveness of the drug used in the Steroid-Enhanced Nerve Block for Uterine Fibroids Pain Relief?
Who Is on the Research Team?
Jessica K Stewart, MD
Principal Investigator
University of California, Los Angeles
Are You a Good Fit for This Trial?
This trial is for women aged 30-60 with painful uterine fibroids or adenomyosis who are scheduled for a Uterine Artery Embolization (UAE) procedure. It's not suitable for those with conditions making UAE unsafe, bleeding disorders, diabetes, allergies to anesthetics or steroids, and certain bowel diseases.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo the Uterine Artery Embolization (UAE) procedure with a Superior Hypogastric Nerve Block (SHNB) using either bupivacaine with triamcinolone or bupivacaine alone
Follow-up
Participants are monitored for pain intensity and medication use post-procedure
What Are the Treatments Tested in This Trial?
Interventions
- Bupivacaine
- Triamcinolone
Bupivacaine is already approved in United States, European Union, Canada for the following indications:
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
- Local anesthesia for surgery
- Acute pain management
- Spinal anesthesia
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of North Carolina, Chapel Hill
Lead Sponsor
University of California, Los Angeles
Lead Sponsor