Browse 197 Exparel Medical Studies Across 128 Cities
27 Phase 3 Trial · 258 Exparel Clinics
What Are Exparel Clinical Trials?
Exparel is the brand name for the medication called Bupivacaine. It is a local anaesthetic used as an analgesic for severe pain such as dental pain or post-surgical pain. The medication is used as a nerve block for pain relief either in conjunction with opioid medications or in lieu of them, in order to help to decrease the number of prescriptions or medications on order that are contributing to the opioid crisis.
The medication is also a fast acting medication, often working as quickly as within 15 minutes of administration. Exparel clinical trials consistently work to determine what combination of medications Exparel works best with, in order to determine how to administer Exparel to produce the fastest and most effective, and long-lasting pain relief.
Why Is Exparel Being Studied In Clinical Trials?
Bupivacaine was discovered in 1957 and there is no dispute as to its effectiveness as a local anaesthetic or analgesic for pain relief. Today it is branded as Exparel. The most commonly used formulation of bupivacaine or Exparel did not receive approval by the Federal Drug Administration (FDA) until 2011.
Because there are so many modes of treatment for pain relief, Exparel is often used in conjunction with many other medications or treatments. Additionally, there are many different modes of administration with Exparel. As such, Exparel clinical trials help scientists and doctors reach those answers so that they can find the best pain relief for their patients suffering from moderate to severe pain.
How Does Exparel Treatment Work?
Exparel is a local anaesthesia and analgesic for pain relief, and it functions as a nerve blocking agent. It is often formulated with the chemical known as epinephrine, a chemical in the brain that helps us to feel stimulated with feelings of happiness or relaxation. The medication is given by injection, and its mechanisms function three phrases once inside the human system.
Once injected, the medicine undergoes three phases that includes an initial burst phase, a lag phase, and a phase of secondary release. This is how the medication can begin to act quickly, and provide pain relief that lasts a long time.
What Are Some of the Breakthrough Clinical Trials Involving Exparel?
Pain medication is an area of medicine that is complex but comprehensive. There are thousands of medications that can treat pain that are not opioids, and Exparel is one of them. The medication known as Exparel is a local analgesic for pain relief that has been used for many years. There have been some fascinating Exparel clinical trials that indicate it can be a very effective medication.
2015: A blind study on extended release Exparel was conducted in order to determine if it would be effective on patients just out of knee surgery. This study found that when Exparel was used, less pain was reported, but more pain relief was found in the control group with opioid medication, leading researchers to determine that routine use of Exparel was not recommended after knee surgery, despite its effectiveness in other areas. It is a critical piece of research because it notes the limitations of Exparel, something important in the field of pain management. This study will prevent the use of Exparel in medical environments where a better treatment method may be available.
Who Are The Key Opinion Leaders On Exparel Clinical Trial Research?
Aaron Skolnik, M.D.
Dr. Aaron Skolnik is a renowned surgeon with the Mayo Clinic who has studied and researched post-operative surgical pain, and the local anaesthetic known as Exparel, considerably. His operative work includes kidney injury and heart failure, and he is a specialist in the areas of other major organ issues include liver and lung failure. He has published a wide body of research on Exparel and other forms of pain management suitable for a post-surgical setting.