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Local Anesthetic

Anesthetic Techniques for Pain and Anesthesia

N/A
Waitlist Available
Led By Roya Yumul, MD, PhD
Research Sponsored by Cedars-Sinai Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of abdominal tumor scheduled for exploratory laparotomy with study surgeon
Must be able to have an epidural
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one year
Awards & highlights

Study Summary

This trial will compare the effects of two anesthetic techniques on natural killer cells in patients undergoing abdominal surgery.

Who is the study for?
This trial is for adults aged 18-80 with an abdominal tumor scheduled for exploratory surgery, who can have an epidural. It's not for those with severe health issues like heart disease, uncontrolled high blood pressure, significant psychological disorders, or certain medication use. Pregnant women and individuals with obesity or organ failure are also excluded.Check my eligibility
What is being tested?
The study compares the effects of two anesthesia methods using Bupivacaine alone versus Bupivacaine combined with Fentanyl on natural killer cells in patients having abdominal surgery. It's a pilot study where participants are randomly assigned to one of these standard treatments without knowing which one they receive.See study design
What are the potential side effects?
Possible side effects from the interventions may include typical reactions to local anesthetics such as numbness, weakness, low blood pressure, and nausea. Fentanyl might cause drowsiness, nausea, confusion or respiratory depression.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am scheduled for surgery to explore my abdominal tumor.
Select...
I can have an epidural.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Natural Killer Cell Cytotoxicty

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: 'Bupivacaine + Fentanyl' (Opioid Group)Experimental Treatment1 Intervention
Group 1 (opioid group) will receive general endotracheal anesthesia augmented with an epidural. The epidural solution intraoperatively and post-operatively will contain fentanyl + bupivacaine titrated to appropriate surgical conditions and post-operative pain control.
Group II: Bupivacaine (Local Anesthetic Group)Active Control1 Intervention
Group 2 (local anesthetic group) will receive general endotracheal anesthesia augmented with an epidural. The epidural solution intraoperatively and post-operatively will contain bupivacaine titrated to appropriate surgical conditions and post-operative pain control.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupivacaine + Fentanyl
2022
N/A
~40

Find a Location

Who is running the clinical trial?

Cedars-Sinai Medical CenterLead Sponsor
499 Previous Clinical Trials
164,837 Total Patients Enrolled
Roya Yumul, MD, PhDPrincipal InvestigatorProgram Director, Department of Anesthesiology
8 Previous Clinical Trials
406 Total Patients Enrolled

Media Library

Bupivacaine (Local Anesthetic) Clinical Trial Eligibility Overview. Trial Name: NCT02669186 — N/A
Anesthesia Research Study Groups: 'Bupivacaine + Fentanyl' (Opioid Group), Bupivacaine (Local Anesthetic Group)
Anesthesia Clinical Trial 2023: Bupivacaine Highlights & Side Effects. Trial Name: NCT02669186 — N/A
Bupivacaine (Local Anesthetic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02669186 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants have been accepted into this research project thus far?

"Unfortunately, we are not currently admitting participants for this trial. It was initially posted on July 10th 2019 and amended last February 9th 2022. Should you be looking into other trials, there are presently 942 studies recruiting patients with malignancies and 141 experiments seeking individuals who can benefit from Bupivacaine + Fentanyl treatments."

Answered by AI

To what extent have researchers investigated the potential of Bupivacaine + Fentanyl?

"Currently, there are 141 ongoing studies concerning the combination of Bupivacaine and Fentanyl with 26 tests at phase 3. Most clinical experiments for this mixture take place in Germantown, Tennessee yet 204 sites across the world have trials involving it."

Answered by AI

Is this experiment actively seeking participants?

"This clinical trial has closed its recruitment phase, with the initial post on July 10th 2019 and last edit made February 9th 2022. However, there are still numerous studies recruiting participants for malignancies (942) and Bupivacaine + Fentanyl specifically (141)."

Answered by AI

What medical ailments is the Bupivacaine + Fentanyl combination employed to alleviate?

"Bupivacaine + Fentanyl serves as a usual line of treatment for permphigus while also being prescribed to patients with acute nonspecific tenosynovitis, general anaesthesia and lupus erythematosus cell."

Answered by AI

Does this trial cater to participants aged over twenty?

"To be qualified for this medical trial, participants must fall within the age bracket of 18 to 80 years old."

Answered by AI

Am I eligible to join the experiment?

"The requirements to join this trial are a malignant condition and an age between 18 and 80. Currently, the clinical trial is searching for 20 participants in total."

Answered by AI
Recent research and studies
~5 spots leftby Dec 2025