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Exparel/Intervention group for Opioid Use Disorder

Phase 3
Waitlist Available
Led By Thomas K Miller, MD
Research Sponsored by Carilion Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18-65 years old
Presenting to Carilion Clinic Institute of Orthopedics and Neuroscience
Timeline
Screening 3 weeks
Treatment Varies
Follow Up self reported anytime from immediately post-op until 2 weeks post-operatively. likely 1-3 days
Awards & highlights

Study Summary

This study is evaluating whether a local anesthetic injection may help reduce pain for individuals who have had ACL surgery.

Eligible Conditions
  • Anterior Cruciate Ligament Tear
  • Opioid Use Disorder
  • Postoperative Pain

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~self reported anytime from immediately post-op until 2 weeks post-operatively. likely 1-3 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and self reported anytime from immediately post-op until 2 weeks post-operatively. likely 1-3 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Total opioid consumption
Secondary outcome measures
Block length
Pain control quantified by intervention-based pain scale
Pain control quantified by numerical rating scale

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Exparel/Intervention groupExperimental Treatment2 Interventions
Will receive 10mL of standard 0.5% bupivacaine followed by 10mL of liposomal bupivacaine as adductor canal field block preoperatively
Group II: Standard of Care groupActive Control1 Intervention
Will receive 20mL of standard 0.5% bupivacaine as adductor canal field block preoperatively
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupivacaine
FDA approved
Bupivacaine
FDA approved

Find a Location

Who is running the clinical trial?

Carilion ClinicLead Sponsor
70 Previous Clinical Trials
12,655 Total Patients Enrolled
Thomas K Miller, MDPrincipal InvestigatorCarilion Clinic
1 Previous Clinical Trials
17 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
~15 spots leftby Mar 2025