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Local Anesthetic

Exparel for Cardiothoracic Surgery (EXPAREL Trial)

Phase 4
Waitlist Available
Led By Charles T Klodell, MD
Research Sponsored by Florida Heart and Lung Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from post operative day of cardiac surgery through length of hospital admission and through study completion, an average of one year.
Awards & highlights

EXPAREL Trial Summary

Evaluation of Liposomal Bupivacaine Compared to Usual Care and its Effect on Pain for Cardiac Surgery

EXPAREL Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~count the number of days from admission for cardiac surgery to day of hospital discharge through study completion , an average of one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and count the number of days from admission for cardiac surgery to day of hospital discharge through study completion , an average of one year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
20% change in opioids use
Secondary outcome measures
Major Adverse Cardiac Effects of Liposomal Bupivacaine
Pain Scores on Post op day 2,3 and 4
Time to Hospital Discharge
+3 more

EXPAREL Trial Design

2Treatment groups
Active Control
Group I: ExparelActive Control2 Interventions
administration of liposomal bupivacaine 266mg/20mL+ 40 mL bupivacaine 0.25% bupivacaine .
Group II: Standard of TherapyActive Control1 Intervention
administration of 0.25% bupivacaine with epinephrine at 1cc/kg total dose

Find a Location

Who is running the clinical trial?

Florida Heart and Lung InstituteLead Sponsor
Charles T Klodell, MDPrincipal InvestigatorFlorida Heart and Lung Institute, HCA Physician Services

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery
Charles Klodell, MD 2019. "Evaluation of Liposomal Bupivacaine Compared to Usual Care and Its Effects on Pain for Cardiac Surgery". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04065919.
All > Exparel
~55 spots leftby Apr 2025
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