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Occipital Nerve Block for Headache

Phase 4
Waitlist Available
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Women presenting to Maternal Evaluation Unit at UAB hospital
Confirmed live intrauterine pregnancy (previous ultrasound, bedside ultrasound, fetal monitoring)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 60-300 min
Awards & highlights

Study Summary

This trial is testing whether a bupivacaine occipital nerve block is more effective than Tylenol/Caffeine cocktail in treating pregnant patients' headaches.

Eligible Conditions
  • Headache
  • Pregnancy
  • Occipital Nerve Block

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~60-300 min
This trial's timeline: 3 weeks for screening, Varies for treatment, and 60-300 min for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants With Response to Occipital Nerve Block in Pregnancy
Secondary outcome measures
Duration of Headache Free Period at 7 Days
Number of Participants With Development of Hypertensive Disease of Pregnancy Within 28 Days
Number of Participants With Development of Hypertensive Disease of Pregnancy Within 7 Days
+10 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Occipital Nerve blockExperimental Treatment1 Intervention
Trained OB/GYN providers will perform a physical exam to access location of occipital nerve injection based on palpation of bony landmarks. Site of injection will be cleaned with an alcohol swab. 5cc of 0.5% bupivacaine will be injected into both right and left occipital nerves using a 2.5 inch 25 gauge needle. The needle will be changed between injecting sites. After injection is completed sterile gauze will be held on injection sites for 2-3 min or until bleeding is resolved.
Group II: Oral Acetaminophen/Caffeine GroupActive Control1 Intervention
Acetaminophen 650mg PO and Caffeine 100mg PO (both Level A treatments for acute headache)
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Occipital Nerve Block
2020
Completed Phase 4
~70

Find a Location

Who is running the clinical trial?

University of Alabama at BirminghamLead Sponsor
1,583 Previous Clinical Trials
2,279,982 Total Patients Enrolled
1 Trials studying Headache
40,000 Patients Enrolled for Headache

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people can take part in this medical experiment?

"Affirmative. According to clinicaltrials.gov, this experiment was first posted on February 10th 2020 and is currently recruiting participants. 62 individuals are required for the trial at one location."

Answered by AI

Has Occipital Nerve Block been subjected to any previous research?

"Presently, there are 101 clinical trials on Occipital Nerve Block and 28 of them are in Phase 3. Most experiments for this treatment take place in Pittsburgh, Pennsylvania; however, 1123 separate sites offer these studies across the country."

Answered by AI

Is my participation in this investigation permissible?

"This trial is searching for 62 individuals who experience headaches and are aged between 16 to 60 years."

Answered by AI

Has Occipital Nerve Block been granted clearance by the FDA?

"After reviewing the data, we gave Occipital Nerve Block a rating of 3 since it has been officially approved after Phase 4 trials."

Answered by AI

Are there any openings for participation in this investigation?

"Affirmative. The information available on clinicaltrials.gov highlights that this medical trial is currently recruiting candidates with the initial posting dated February 10th 2020 and the most recent update being April 2nd 2022. 62 participants need to be recruited from a single site."

Answered by AI

What medical conditions can be managed through Occipital Nerve Block?

"Occipital Nerve Block is a therapy for conditions related to catarrh such as rhinorrhoea, musculoskeletal pain, and muscle spasms."

Answered by AI

Is this research program open to persons aged thirty and above?

"This clinical study is looking for patients between the ages of 16 and 60."

Answered by AI
Recent research and studies
Headache: The Journal of Head and Face PainJournal
Expert Consensus Recommendations for the Performance of Peripheral Nerve Blocks for Headaches - A Narrative Review
Blumenfeld, Andrew, Avi Ashkenazi, Uri Napchan, Steven D. Bender, Brad C. Klein, Randall Berliner, Jessica Ailani, et al.. 2013. “Expert Consensus Recommendations for the Performance of Peripheral Nerve Blocks for Headaches - A Narrative Review”. Headache: The Journal of Head and Face Pain. Wiley. doi:10.1111/head.12053.
Headache: The Journal of Head and Face PainJournal
General Principles of Migraine Management: The Changing Role of Prevention
Loder, Elizabeth, and David Biondi. 2005. “General Principles of Migraine Management: The Changing Role of Prevention”. Headache: The Journal of Head and Face Pain. Wiley. doi:10.1111/j.1526-4610.2005.4501002.x.
Headache: The Journal of Head and Face PainJournal
Nerve Block for the Treatment of Headaches and Cranial Neuralgias - A Practical Approach
Dach, Fabíola, Álan L. Éckeli, Karen dos S. Ferreira, and José G. Speciali. 2015. “Nerve Block for the Treatment of Headaches and Cranial Neuralgias - A Practical Approach”. Headache: The Journal of Head and Face Pain. Wiley. doi:10.1111/head.12516.
NeurologyJournal
Migraine Prevalence, Disease Burden, and the Need for Preventive Therapy
Lipton, R. B., M. E. Bigal, M. Diamond, F. Freitag, M. L. Reed, W. F. Stewart, and on behalf of the AMPP Advisory Group. 2007. “Migraine Prevalence, Disease Burden, and the Need for Preventive Therapy”. Neurology. Ovid Technologies (Wolters Kluwer Health). doi:10.1212/01.wnl.0000252808.97649.21.
~12 spots leftby Apr 2025
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