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Anesthetic

Spinal anesthesia group for Dementia

N/A
Waitlist Available
Led By George Djaiani, MD
Research Sponsored by University Health Network, Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Male or female
Be older than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline, hospital discharge (3 day average), 3 months, 1 year, and 2 years
Awards & highlights

Study Summary

This trialinvestigates if elderly patients are less likely to develop dementia/Alzheimers if they have spinal (awake/sedated) vs. inhalational (asleep) anesthesia for surgery, taking into account risk factors.

Eligible Conditions
  • Dementia
  • Alzheimer's Disease

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
Both males and females can participate.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline, hospital discharge (3 day average), 3 months, 1 year, and 2 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline, hospital discharge (3 day average), 3 months, 1 year, and 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Assessing the incidence of early dementia

Trial Design

2Treatment groups
Active Control
Group I: Spinal anesthesia groupActive Control4 Interventions
Spinal anesthesia group will receive bupivacaine 10-15mg anesthesia according to the standard practice. Supplemental sedation with intravenous anesthetics (midazolam/propofol) will be optional.
Group II: General anesthesia groupActive Control4 Interventions
Induction of anesthesia will be achieved with propofol 1.5-2mg/kg and fentanyl 1-3g/kg. Anesthesia will be maintained with inhalational anesthesia (isoflurane or sevoflurane) at the discretion of anesthesiologist in charge of the case. A mixture of Air/O2 will be used to maintain adequate oxygenation. Nitrous oxide will not be used.

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor
1,456 Previous Clinical Trials
482,299 Total Patients Enrolled
13 Trials studying Dementia
838 Patients Enrolled for Dementia
George Djaiani, MDPrincipal InvestigatorToronto General Hospital, University Health Network
4 Previous Clinical Trials
1,716 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are permitted to join this experiment?

"Unfortunately, the recruitment period for this trial has closed. It commenced on March 1st 2014 and concluded December 1st 2022; however, if you are seeking other opportunities there are currently 771 trials actively recruiting patients with dementia and 219 studies recruiting participants in the Spinal Anesthesia group."

Answered by AI

For what types of procedures is spinal anesthesia commonly employed?

"Spinal anesthesia is a common therapeutic intervention for permphigus and can, additionally, be used to treat acute nonspecific tenosynovitis, general anesthesia complications, and lupus erythematosus cell."

Answered by AI

What trials have been executed that involved patients administered Spinal anesthesia?

"Presently, 219 clinical trials for Spinal anesthesia group are in operation with 41 of them at Phase 3. The majority focus is located in Bronx, NY yet there are 523 medical sites conducting research on this type of treatment."

Answered by AI

Are there opportunities for individuals to enlist in this research project presently?

"This research is no longer recruiting patients. It was initially posted on March 1st, 2014 and the most recent updates were added December 1st, 2022. For those seeking other trials, 771 studies are actively enrolling individuals with dementia and 219 clinical investigations require participants in a Spinal Anesthesia group."

Answered by AI
~45 spots leftby Mar 2025