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Local Anesthetic

Bupivacaine Injection for Graves Disease

Phase 2 & 3
Waitlist Available
Led By Alan B Scott, MD
Research Sponsored by Smith-Kettlewell Eye Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Clinical pattern of strabismus of 5 prism diopters or more
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months after injection treatment
Awards & highlights

Study Summary

This trial will test if a bupivacaine injection into eye muscles can make them stronger to fix mis-aligned or turned in eyes, strabismus. Different concentrations and formulations of bupivacaine will be tested as well as if Botox added to other eye muscles can help the effect.

Eligible Conditions
  • Graves Disease
  • Crossed Eyes
  • Strabismus
  • Drooping Eyelid

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months after injection
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months after injection for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Eye alignment
Secondary outcome measures
Percentage correction of the pre-treatment eye deviation

Trial Design

1Treatment groups
Experimental Treatment
Group I: Bupivacaine InjectionExperimental Treatment1 Intervention
Differences in concentration from 0.75% to 3.0% are compared. Differences in volume for 1.0 mL to 3.0 mL are compared. Differences in compounding with addition of epinephrine will be used and compared to plain bupivacaine.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Bupivacaine
FDA approved

Find a Location

Who is running the clinical trial?

Smith-Kettlewell Eye Research InstituteLead Sponsor
4 Previous Clinical Trials
253 Total Patients Enrolled
EidacticsOTHER
Sutter HealthOTHER
21 Previous Clinical Trials
156,780 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Bupivacaine Injection of Eye Muscles to Treat Strabismus
Alan B. Scott 2012. "Bupivacaine Injection of Eye Muscles to Treat Strabismus". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01616108.
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~9 spots leftby Apr 2025
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