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Corticosteroid

bupivacaine (Exparel) for Migraine

Phase 1 & 2
Waitlist Available
Led By Brian Grosberg, MD
Research Sponsored by Hartford HealthCare
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up first week
Awards & highlights

Study Summary

The main goal of this study is to determine whether it is possible - in the setup of routine clinical care - to identify in individual patients who are clear responders to drug X, common denominators that are absent in individual patients who are non-responders to the same drug, and vice versa. All currently available knowledge about migraine pathophysiology will be utilized, using as much time as is needed to ask as many questions as are necessary, in an attempt to profile clear responders and clear non-responders.

Eligible Conditions
  • Migraine

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~first week
This trial's timeline: 3 weeks for screening, Varies for treatment, and first week for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
time to headache relief

Trial Design

4Treatment groups
Active Control
Group I: bupivacaine (Exparel)Active Control1 Intervention
subjects assigned by clinician's judgment - standard care choice A
Group II: naratriptan pill (Amerge)Active Control1 Intervention
subjects assigned by clinician's judgment - standard care choice B
Group III: dexamethasone tablet (Decadron)Active Control1 Intervention
subjects assigned by clinician's judgment - standard care choice C
Group IV: ketorolac (Toradol)Active Control1 Intervention
subjects assigned by clinician's judgment - standard care choice D

Find a Location

Who is running the clinical trial?

Hartford HealthCareLead Sponsor
8 Previous Clinical Trials
1,234 Total Patients Enrolled
Brian Grosberg, MDPrincipal Investigatorphysician
1 Previous Clinical Trials
126 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Status Migrainosus - Differentiating Between Responders and Non-responders
David O'Sullivan 2016. "Status Migrainosus - Differentiating Between Responders and Non-responders". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03066544.
All > Exparel
~6 spots leftby Apr 2025
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