Standardized Dialysis for Acute Kidney Injury

(Recover-AKI Trial)

Overseen By Samuel A Silver

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Samuel Silver

Disqualifiers: Dialysis ≥90 days, eGFR <15, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 months

110 Participants Needed

Trial Summary

What is the purpose of this trial?

This trial aims to test if using a consistent method for performing dialysis is feasible compared to letting each patient's kidney doctor decide the treatment specifics. The study focuses on patients with Acute Kidney Injury who are already receiving dialysis. The goal is to see if a standardized approach can improve care or make it easier to manage.

Research Team

Samuel A Silver

Principal Investigator

Queen's University

Eligibility Criteria

This trial is for patients who have had acute kidney injury and received at least two dialysis sessions, with plans to continue. It's not for those on dialysis for over 90 days, with certain pre-existing conditions like severe chronic kidney disease or specific acute renal diseases, recent kidney transplant recipients, or pregnant individuals.

Inclusion Criteria

I am planning to continue with my dialysis treatments.

I have undergone at least 2 dialysis treatments for acute kidney injury.

Exclusion Criteria

I am suspected to have a serious kidney condition causing my acute kidney injury.

Pregnant

I have not had dialysis in the last 2 months before this hospital visit.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either a standardized dialysis strategy or usual care as prescribed by their primary nephrologist

6 months

Follow-up

Participants are monitored for safety and effectiveness after treatment, including dialysis-free days and hypotensive events

6 months

Treatment Details

Interventions

• Standardized Dialysis and Structured Discontinuation (S2D2)
• Usual Care

Trial Overview The study compares a standardized dialysis strategy (S2D2) against the usual care where each patient's primary nephrologist decides the treatment. The aim is to see if it's feasible to do a larger trial on this approach in patients recovering from acute kidney injury.

Participant Groups

Group I: Standardized Dialysis and Structured Discontinuation (S2D2) Experimental Treatment 1 Intervention

Prescription to minimize dialysis-induced ischemia and standardize dialysis discontinuation

Group II: Usual Care Active Control 1 Intervention

Dialysis prescription ordered by their primary nephrologist/intensivist.

Who Is Running the Clinical Trial?

Samuel Silver

Lead Sponsor

Trials

2

Recruited

510+

Samuel Silver

Lead Sponsor

Trials

2

Recruited

510+

Unity Health Toronto

Collaborator

Trials

572

Recruited

470,000+