Pre-Surgery Radiation Therapy for Mesothelioma
(SMARTER Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This study aims to find the maximum tolerated dose level for malignant pleural mesothelioma patients receiving background radiation + boost radiation, and surgery. Boost radiation is an experimental form of radiation that involves targeting non-uniform high doses of radiation to bulky pleural masses. We hypothesize the immunologic abscopal effect is an important component in controlling disease, and may be stimulated with highly hypofractionated doses. Doses will increase with every three patients who will be enrolled in the study until the background radiation reaches 1800 cGy or the maximum tolerated dose, whichever is lower.
Who Is on the Research Team?
John Cho, MD
Principal Investigator
Princess Margaret Hospital, Canada
Are You a Good Fit for This Trial?
Adults over 18 with early-stage malignant pleural mesothelioma, good lung function, and performance status. They must be new diagnoses without prior thoracic radiation or chemotherapy for this cancer or others within the last 3 years (except certain non-invasive cancers). Pregnant women are excluded.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiation
Participants receive background and boost radiation therapy to determine the maximum tolerated dose
Surgery
Surgery is performed approximately 1-2 weeks after completing radiation therapy
Follow-up
Participants are monitored for safety, effectiveness, and quality of life after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Background and Boost RT
- Surgery for Mesothelioma
Find a Clinic Near You
Who Is Running the Clinical Trial?
University Health Network, Toronto
Lead Sponsor