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RSC-1255 for Advanced Cancers

Phase 1
Recruiting
Research Sponsored by RasCal Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Malignancy has progressed on standard therapy
Has pathologically confirmed advanced or metastatic malignancy characterized by one or more of the following:
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately 24 months
Awards & highlights

Study Summary

This trial is testing a new drug, RSC-1255, for people with advanced solid tumors who can't tolerate other treatments or who have already failed other treatments. The study has two parts: first, they'll determine the best dose of the drug, and then they'll test its safety and effectiveness.

Who is the study for?
This trial is for adults with advanced solid tumors who have not responded to, or can't tolerate, standard treatments. It's open to those with certain types of cancer like lung and colon cancer, where the tumor can be measured by scans or tests. Participants must be over 18 and in stable condition as judged by ECOG performance status.Check my eligibility
What is being tested?
RSC-1255 is being tested in two phases: Phase 1a determines the safe dosage level while Phase 1b assesses its safety and effectiveness against various advanced cancers. The study aims to find out if RSC-1255 can help patients whose cancers haven't improved with other treatments.See study design
What are the potential side effects?
As this is an early-phase trial for a new drug, specific side effects are not yet fully known but may include typical reactions seen with cancer therapies such as fatigue, nausea, skin reactions, blood count changes leading to increased infection risk or bleeding tendencies.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My cancer has worsened despite treatment.
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My cancer is advanced or has spread to other parts of my body.
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My cancer has not responded to any treatment known to work.
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My cancer can be measured or evaluated using scans or tests.
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I am able to carry out daily activities with minimal assistance.
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I am 18 years old or older.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately 24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maximum Tolerated Dose (MTD) for RSC-1255 as monotherapy
Recommended Phase 2 Dose (RP2D) for RSC-1255 as monotherapy
Secondary outcome measures
Adverse event profile of RSC-1255
Overall Survival (OS)

Trial Design

1Treatment groups
Experimental Treatment
Group I: RSC-1255 TreatmentExperimental Treatment2 Interventions
Single Arm Study. All study participants receive RSC-1255.

Find a Location

Who is running the clinical trial?

RasCal Therapeutics, Inc.Lead Sponsor
Robert Reder, MDStudy DirectorRasCal Therapeutics, Inc.
1 Previous Clinical Trials
122 Total Patients Enrolled

Media Library

Cancer Clinical Trial 2023: RSC-1255 Highlights & Side Effects. Trial Name: NCT04678648 — Phase 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many sites are hosting this research program?

"Currently, 6 distinct sites are managing this particular trial. These locations span from Nashville to Denver and Los Angeles with additional medical centres located elsewhere. In order to reduce travel obligations, it is best for participants to opt into a site that is closest in proximity."

Answered by AI

Has the FDA certified RSC-1255 Dose Escalation for use?

"We at Power rate the safety of RSC-1255 Dose Escalation with a score of 1 due to its Phase 1 status, meaning there is limited clinical evidence supporting both efficacy and safety."

Answered by AI

How many participants are required for this research project?

"This clinical trial needs to enroll 134 qualified individuals across multiple sites. Notable locations include Sarah Cannon Tennessee Oncology in Nashville and the Sarah Cannon Research Institute - Health One located in Denver, Colorado."

Answered by AI

Are recruitment efforts still underway for this clinical experiment?

"Information available on clinicaltrials.gov reveals that this trial is actively looking for volunteers and has been since February 2021, with their most recent update taking place in October of 2022."

Answered by AI

Who else is applying?

What state do they live in?
Nevada
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
0
Recent research and studies
clinicaltrials.govStudy
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
2021. "A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04678648.
~32 spots leftby Apr 2025
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