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GLP-1 and GIP for Low Blood Sugar

South Texas Veterans Health Care System, San Antonio, TX
Low Blood Sugar+1 More ConditionsGLP-1 and GIP - Drug
Eligibility
18 - 65
All Sexes

Study Summary

This trial is studying how well gastric bypass surgery works in treating patients with type 2 diabetes.

Eligible Conditions
  • Post-Bariatric Surgery
  • Low Blood Sugar

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase < 1

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1
Atropine
1
Glucose clamp
1
Hyperglycemic Clamp

Study Objectives

1 Primary · 0 Secondary · Reporting Duration: Each study of the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.

Each study of the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.
Gut hormones and neural signaling contribution to insulin secretion rate and glucose tolerance

Trial Safety

Phase-Based Safety

1 of 3

Similar Trials

1
Atropine
1
Glucose clamp
1
Hyperglycemic Clamp

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.

Trial Design

3 Treatment Groups

Exendin-(9-39)
1 of 3
GLP-1 and GIP
1 of 3
atropine
1 of 3

Experimental Treatment

160 Total Participants · 3 Treatment Groups

Primary Treatment: GLP-1 and GIP · No Placebo Group · Phase < 1

Exendin-(9-39)
Drug
Experimental Group · 1 Intervention: Exendin-(9-39) · Intervention Types: Drug
GLP-1 and GIP
Drug
Experimental Group · 1 Intervention: GLP-1 and GIP · Intervention Types: Drug
atropine
Drug
Experimental Group · 1 Intervention: Atropine · Intervention Types: Drug
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Atropine
FDA approved
Exendin-(9-39)
2009
Completed Phase 2
~40

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: each study of the protocol is conducted up to seven hours with data collected at intervals specific to the individual study procedure.

Who is running the clinical trial?

The University of Texas Health Science Center at San AntonioLead Sponsor
418 Previous Clinical Trials
80,852 Total Patients Enrolled
Marzieh Salehi, MD, MSPrincipal InvestigatorMarzieh Salehi
1 Previous Clinical Trials
200 Total Patients Enrolled

Eligibility Criteria

Age 18 - 65 · All Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
People who had bariatric surgery but do not have any symptoms related to it.
References

Frequently Asked Questions

Does this research allow geriatric participants?

"This clinical trial requires that participants are within the 18 to 65 age range. For those outside of this demographic, there are 24 studies for minors and 68 trials specifically geared towards elderly patients." - Anonymous Online Contributor

Unverified Answer

To what ailment are GLP-1 and GIP most often prescribed?

"GLP-1 and GIP are clinically used to reduce cases of uncontrolled lauging, as well as ailments such as rhinorrhoea, pupil constriction, and secretion of bile." - Anonymous Online Contributor

Unverified Answer

Am I eligible to enroll in this clinical trial?

"To be eligible to partake in this clinical trial, potential participants must have hypoglycemia and fall within the 18-65 age bracket. Additionally, they should be asymptomatic bariatric surgery patients or healthy individuals with no history of diabetes; Lastly, they must also possess enough mobility to come our research centre at Cedars-Sinai Medical Center." - Anonymous Online Contributor

Unverified Answer

How many volunteers are participating in this clinical experiment?

"Affirmative. Data hosted on clinicaltrials.gov suggests that this medical experiment, initially posted October 1st 2009, is actively searching for participants. 160 individuals need to be enrolled across 2 sites." - Anonymous Online Contributor

Unverified Answer

What past experiments have utilized GLP-1 and GIP in the study of treatments?

"Currently, 22 clinical trials are investigating GLP-1 and GIP with 6 of these studies in the final Phase 3. Shanghai is hosting some of them but there are 149 global locations engaged in this research effort." - Anonymous Online Contributor

Unverified Answer

Is there currently an open enrollment period for this trial?

"Clinicaltrials.gov affirms that this medical experiment, initially launched on October 1st 2009, is presently recruiting for participants. The trial details were last revised August 5th 2022." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

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