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Sleep Deprivation for Depression

N/A
Recruiting
Research Sponsored by Stony Brook University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18 years or older (inclusive)
Diagnosis of MDD and currently in a major depressive episode (depressed participants only)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

Study Summary

This trial is studying the effects of sleep deprivation on depression.

Who is the study for?
This study is for adults over 18 with Major Depressive Disorder (MDD) currently experiencing a major depressive episode. Participants must be able to consent, sign a form, and score at least 29 on the MADRS. They can't join if they consume too much caffeine or alcohol, have irregular sleep/wake cycles, are pregnant/lactating/planning pregnancy, have MRI/PET scan contraindications, use certain medications/substances including nicotine or are at risk of suicide.Check my eligibility
What is being tested?
The trial investigates how disrupting the sleep/wake cycle affects depression by keeping participants awake for one night. It aims to understand circadian rhythm's role in depression and uses brain scans to study brain chemistry changes. Afterward, depressed participants receive free antidepressant medication.See study design
What are the potential side effects?
Staying awake all night may lead to temporary tiredness and mood improvements lasting less than a day for those with depression. Brain scans used in this study are generally safe but may pose risks related to exposure to magnetic fields or injected tracers.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 18 years old or older.
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I have been diagnosed with major depressive disorder and am currently experiencing a major depressive episode.
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I understand the details of the trial and can agree to participate.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Measure circadian phase in depressed and non-depressed individuals using the following outcome measure: phase angle difference (DLMO - sleep midpoint, units: hours)
Secondary outcome measures
Measure mGluR5 expression (outcome measure: volume of distribution divided by free fraction) at the time of DLMO, peak and nadir of melatonin secretion.
Melatonin
To determine whether reliable estimates of [11C]ABP688 in plasma can be obtained using a miniPET scanner.

Trial Design

1Treatment groups
Experimental Treatment
Group I: InterventionExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Stony Brook UniversityLead Sponsor
216 Previous Clinical Trials
39,919 Total Patients Enrolled
16 Trials studying Depression
7,433 Patients Enrolled for Depression

Media Library

Sleep Deprivation Clinical Trial Eligibility Overview. Trial Name: NCT04350567 — N/A
Depression Research Study Groups: Intervention
Depression Clinical Trial 2023: Sleep Deprivation Highlights & Side Effects. Trial Name: NCT04350567 — N/A
Sleep Deprivation 2023 Treatment Timeline for Medical Study. Trial Name: NCT04350567 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment open to individuals younger than 70 years for this clinical research?

"To be eligible for this clinical trial, the age range must fall between 18 and 100 years old."

Answered by AI

Who meets the criteria to take part in this scientific research?

"This clinical trial requires that participants suffer from depression and can be between 18 to 100 years of age. A total of 52 individuals are being recruited for this venture."

Answered by AI

Are there any vacancies for participants in the trial?

"According to the records hosted on clinicaltrials.gov, this medical research project is actively looking for participants, having been initially posted September 1st 2020 and last modified January 30th 2022."

Answered by AI

What is the current size of the sample population in this medical study?

"Affirmative. As per the information provided on clinicaltrials.gov, this medical trial is presently seeking enrolment of 52 total individuals at a single location. The original posting date was September 1st 2020 and it has been amended most recently on January 30th 2022."

Answered by AI

Who else is applying?

What state do they live in?
Florida
Connecticut
What site did they apply to?
Stony Brook University Hospital
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+
Recent research and studies
clinicaltrials.govStudy
Sleep/Wake Cycle and Depression: An Imaging and Treatment Study
Christine DeLorenzo 2020. "Sleep/Wake Cycle and Depression: An Imaging and Treatment Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04350567.
All > Depression New York
~13 spots leftby Aug 2025
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