Fisetin for lipocalin 1
Phase-Based Progress Estimates
Effectiveness
Safety
UK Healthcare at Turfland, Lexington, KY
lipocalin 1+3 More
Fisetin - DrugEligibility
18 - 65
All Sexes
What conditions do you have?
Select
Eligibility
18 - 65
All Sexes
What conditions do you have?
Select
Study Summary
Arthroscopic meniscal procedures are the most commonly performed orthopaedic procedure in the U.S. affecting 15% of Americans ages 10-65 years. Meniscus injury is also known to increase the risk of posttraumatic osteoarthritis (PTOA). The current randomized clinical trial will test a novel intervention after meniscal repair that combines an oral senolytic fisetin and real-time biofeedback program to restore joint loading and subsequent return to activity.
Eligible Conditions
- Meniscus Disorder
- lipocalin 1
- Meniscus Lesion
- Meniscus; Derangement
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 1 Secondary · Reporting Duration: Baseline, 1 year
Baseline, 1 year
Change in International Knee Documentation Committee (IKDC) Score between baseline and 1 year
Change in MRI T1rho between baseline and 1 year
Trial Safety
Safety Progress
This is further along than 68% of similar trials
Trial Design
2 Treatment Groups
Fisetin
1 of 2
Placebo
1 of 2
Experimental Treatment
Non-Treatment Group
38 Total Participants · 2 Treatment Groups
Primary Treatment: Fisetin · Has Placebo Group · Phase 2 & 3
Fisetin
Drug
Experimental Group · 1 Intervention: Fisetin · Intervention Types: DrugPlacebo
Drug
PlaceboComparator Group · 1 Intervention: Placebo oral capsule · Intervention Types: DrugTrial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, 1 year
Closest Location: UK Healthcare at Turfland · Lexington, KY
2019First Recorded Clinical Trial
0 TrialsResearching lipocalin 1
3 CompletedClinical Trials
Who is running the clinical trial?
Austin V StoneLead Sponsor
4 Previous Clinical Trials
84 Total Patients Enrolled
Austin Stone, MD, PhDPrincipal InvestigatorUniversity of Kentucky
2 Previous Clinical Trials
6 Total Patients Enrolled
Eligibility Criteria
Age 18 - 65 · All Participants · 5 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:You are between the ages of 18 and 45.
You have a medial, lateral or combined meniscus tear that has been treated with surgical repair.
About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
Popular Clinical Trials
Top Clinical Trials in Cities
Relevant Clinical Trials
Unbiased Results
We believe in providing patients with all the options.Your Data Stays Your Data
We only share your information with the clinical trials you're trying to access.Verified Trials Only
All of our trials are run by licensed doctors, researchers, and healthcare companies.Back to top
Conditions
Cancer Related
Treatments