Fisetin for Meniscus Tears
What You Need to Know Before You Apply
What is the purpose of this trial?
Arthroscopic meniscal procedures are the most commonly performed orthopaedic procedure in the U.S. affecting 15% of Americans ages 10-65 years. Meniscus injury is also known to increase the risk of posttraumatic osteoarthritis (PTOA). The current randomized clinical trial will test a novel intervention after meniscal repair that combines an oral senolytic fisetin and real-time biofeedback program to restore joint loading and subsequent return to activity.
Will I have to stop taking my current medications?
The trial requires that you have been on a stable dose of your current medications for at least 2 months before starting the study. However, you may need to stop certain medications, such as Losartan, Warfarin, opioid analgesics, senolytic agents, and some chemotherapy drugs, among others. It's best to discuss your specific medications with the study team to see if any changes are needed.
Is fisetin generally safe for humans?
How does the drug fisetin differ from other treatments for meniscus tears?
What data supports the effectiveness of the drug Fisetin for meniscus tears?
Who Is on the Research Team?
Austin Stone, MD
Principal Investigator
University of Kentucky
Are You a Good Fit for This Trial?
This trial is for men and women aged 18-45 who have had a surgical repair for a meniscus tear in the knee. Participants must be able to walk and follow study procedures, with stable medication use for at least 2 months before the trial. Excluded are those unable to consent or take oral meds, recent knee surgery patients, certain drug users (e.g., Warfarin), pregnant/nursing women, and individuals with severe liver/renal disease or joint diseases.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive the mechanobiologic intervention, including oral fisetin and real-time biofeedback, starting 8 weeks after surgery
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of physical function and cartilage composition
What Are the Treatments Tested in This Trial?
Interventions
- Fisetin
- Real-time Biofeedback Program
Find a Clinic Near You
Who Is Running the Clinical Trial?
Austin V Stone
Lead Sponsor