Viberzi

Irritable Bowel Syndrome
Treatment
2 FDA approvals
2 Active Studies for Viberzi

What is Viberzi

EluxadolineThe Generic name of this drug
Treatment SummaryEluxadoline is a medication used to treat diarrhea-predominant irritable bowel syndrome (IBS-D). It works by activating and blocking certain opioid receptors in the brain and gastrointestinal systems, which reduces colonic motility, improves pain relief, and decreases bowel contractions. It is marketed under the name Viberzi and is known to reduce abdominal pain and improve symptoms on the Bristol Stool Scale.
Viberziis the brand name
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Viberzi Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Viberzi
Eluxadoline
2015
2

Approved as Treatment by the FDA

Eluxadoline, also known as Viberzi, is approved by the FDA for 2 uses such as Diarrhoea Predominant Irritable Bowel Syndrome and Irritable Bowel Syndrome .
Diarrhoea Predominant Irritable Bowel Syndrome
Helps manage Diarrhoea Predominant Irritable Bowel Syndrome
Irritable Bowel Syndrome
Helps manage Diarrhoea Predominant Irritable Bowel Syndrome

Effectiveness

How Viberzi works in the bodyEluxadoline is a drug used to treat diarrhea-predominant irritable bowel syndrome. It works by activating certain opioid receptors in the body, while blocking others to lessen side effects. This reduces intestinal contractions and helps normalize the speed at which food moves through the digestive system. Eluxadoline has a low absorption rate, meaning it has fewer side effects than other treatments for IBS.

When to interrupt dosage

The proposed measure of Viberzi is contingent upon the recognized condition. The dosage fluctuates as per the technique of delivery (e.g. Tablet or Tablet, film coated) indicated in the table below.
Condition
Dosage
Administration
Irritable Bowel Syndrome
, 75.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

Viberzi Contraindications
Condition
Risk Level
Notes
Gallbladder
Do Not Combine
Mechanical Intestinal Obstruction
Do Not Combine
Pancreatic duct obstruction
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Alcoholism
Do Not Combine
Disease
Do Not Combine
sequelae from constipation
Do Not Combine
Constipation
Do Not Combine
Bile duct structure
Do Not Combine
Pancreatitis
Do Not Combine
There are 20 known major drug interactions with Viberzi.
Common Viberzi Drug Interactions
Drug Name
Risk Level
Description
Methylene blue
Major
Eluxadoline may increase the serotonergic activities of Methylene blue.
Methylnaltrexone
Major
Eluxadoline may increase the opioid antagonism activities of Methylnaltrexone.
Mirtazapine
Major
Eluxadoline may increase the serotonergic activities of Mirtazapine.
Naloxegol
Major
Eluxadoline may increase the opioid antagonism activities of Naloxegol.
Alloin
Minor
The therapeutic efficacy of Alloin can be decreased when used in combination with Eluxadoline.
Viberzi Toxicity & Overdose RiskThe most common side effects of drug overdose are constipation, nausea, and stomach pain.
image of a doctor in a lab doing drug, clinical research

Viberzi Novel Uses: Which Conditions Have a Clinical Trial Featuring Viberzi?

Presently, 3 active trials are being conducted to determine the efficacy of Viberzi in alleviating Diarrhoea Predominant Irritable Bowel Syndrome.
Condition
Clinical Trials
Trial Phases
Irritable Bowel Syndrome
1 Actively Recruiting
Phase 4

Viberzi Reviews: What are patients saying about Viberzi?

5Patient Review
10/1/2019
Viberzi for Diarrhea Predominant Irritable Colon
This medication has been a total game-changer for me. It's the only one that has helped control my IBS to the point where I can actually live a normal life again, rather than just worrying about where the nearest restroom is. One pill a day works for me, but everyone is different. It's pricey, but it's worth it.
5Patient Review
11/28/2018
Viberzi for Diarrhea Predominant Irritable Colon
This treatment has helped me immensely with my bowel movements and diarrhea. I haven't had a bout of diarrhea in over two weeks, and the number of bowel movements has decreased significantly.
5Patient Review
7/11/2018
Viberzi for Diarrhea Predominant Irritable Colon
This treatment has allowed me to take back control of my IBS. It's been 20 years since anything has worked this well for me. If you suffer from IBS, this is worth a try.
5Patient Review
3/9/2018
Viberzi for Diarrhea Predominant Irritable Colon
The low dosage of 50mg really helped me a lot with my irritable bowel syndrome.
5Patient Review
7/12/2016
Viberzi for Diarrhea Predominant Irritable Colon
Viberzi has helped my IBS-D a lot, but it comes with the cost of increased jitteriness and anxiety. It also makes me feel fuller for longer periods of time, which is nice. My mom, who is 75 years old, is also on this medication and it's working great for her too.
View All Reviews
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Patient Q&A Section about viberzi

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is Viberzi considered a controlled substance?

"VIBERZI is federally controlled because it has potential for abuse and dependence, but it has been designated as a low potential for abuse and low risk of dependence."

Answered by AI

Why is Viberzi a narcotic?

"No, Viberzi (eluxadoline) is not considered a narcotic. Viberzi (eluxadoline) does attach to some of the same receptors as opioids, but it works mostly in the intestines (gut) and doesn't cause the behavioral side effects like opioids."

Answered by AI

What should you not do with Viberzi?

"Do not use Viberzi if you have any of the following conditions: a pancreas disorder, severe liver disease, alcoholism, a blockage in your intestines, a gallbladder disorder, or no gallbladder. Viberzi may cause pancreatitis or constipation, which could be severe or lead to hospitalization."

Answered by AI

How does Viberzi make you feel?

"The clinical trials for Viberzi reported that a small number of patients who took the drug as prescribed reported feeling euphoric or drunk. Because eluxadoline, the main ingredient in Viberzi, can cause feelings of euphoria, the drug has the potential to be abused and lead to drug dependence."

Answered by AI

Does Viberzi get you high?

"The drug Viberzi has the potential to be abused because it can cause feelings of euphoria. This is because the main ingredient, eluxadoline, can cause these feelings. However, it is not common for patients who take the drug at normal dosages to report these feelings."

Answered by AI

Is Viberzi the same as Imodium?

"What are some of the key ways in which VIBERZI distinguished itself from other medicines used to treat occasional cases of IBS-D? For one, VIBERZI is a prescription medicine that is FDA approved for daily use, meaning it is designed to be taken more regularly than medicines like Imodium® and Pepto-Bismol®. Additionally, VIBERZI is intended to reduce both abdominal pain and diarrhea simultaneously, whereas other medicines typically only address one or the other."

Answered by AI

What is the drug Viberzi used for?

"This medication is designed to treat a specific stomach/abdominal disorder known as irritable bowel syndrome with diarrhea, or IBS-D. The active ingredient in this medication works by slowing down the natural motility of the gut, which in turn provides symptom relief from conditions such as abdominal pain and diarrhea."

Answered by AI

Clinical Trials for Viberzi

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