Rozerem

Insomnia

Treatment

1 FDA approval

0 Active Studies for Rozerem

What is Rozerem

Ramelteon

The Generic name of this drug

Treatment Summary

Ramelteon is a medication used to treat insomnia, especially difficulty falling asleep. It works by targeting the melatonin receptors in the brain to help regulate sleep patterns. Ramelteon is not known to be addictive or abused and has been found to be safe and effective.

Rozerem

is the brand name

image of different drug pills on a surface

Rozerem Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Rozerem

Ramelteon

2005

29

Approved as Treatment by the FDA

Ramelteon, also known as Rozerem, is approved by the FDA for 1 uses including Insomnia .

Insomnia

Helps manage Insomnia

Effectiveness

How Rozerem Affects Patients

Ramelteon is a drug that helps with sleep problems. It works by imitating the hormone melatonin, which is produced when we sleep and helps to regulate our body's 24-hour "master clock". Ramelteon targets two specific receptors in the brain, called MT<sub>1</sub> and MT<sub>2</sub>, which are responsible for controlling our sleep-wake cycle. It also has a metabolite that is less powerful but circulates in the body at higher levels than the original compound, and it has a slight effect on the 5HT2b receptor.

How Rozerem works in the body

Ramelteon is a medication that helps promote sleep. It works by targeting two types of melatonin receptors, MT1 and MT2, which are associated with sleepiness and sleep onset. It does not target the MT3 receptor, which has a different effect on the body, or any other receptors associated with neurotransmitters, hormones, or opiates.

When to interrupt dosage

The recommended amount of Rozerem is contingent upon the diagnosed condition. The exact dosage is contingent upon the administration approach featured in the table below.

Condition

Dosage

Administration

Insomnia

, 8.0 mg

, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet - Oral, Tablet

Warnings

Rozerem Contraindications

Condition

Risk Level

Notes

Sleep Apnea Syndromes

Do Not Combine

Severe Hepatic Impairment

Do Not Combine

Pharmacotherapy

Do Not Combine

Pulse Frequency

Do Not Combine

development of angioedema

Do Not Combine

There are 20 known major drug interactions with Rozerem.

Common Rozerem Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Deutetrabenazine

Major

The risk or severity of sedation and somnolence can be increased when Ramelteon is combined with Deutetrabenazine.

Ethanol

Major

Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Ramelteon is combined with Oliceridine.

Sodium oxybate

Major

Ramelteon may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.

image of a doctor in a lab doing drug, clinical research

Rozerem Novel Uses: Which Conditions Have a Clinical Trial Featuring Rozerem?

82 current clinical trials are assessing the potential of Rozerem to reduce symptoms of Insomnia.

Condition

Clinical Trials

Trial Phases

Insomnia

0 Actively Recruiting

Rozerem Reviews: What are patients saying about Rozerem?

5

Patient Review

1/3/2019

Rozerem for Chronic Trouble Sleeping

Despite some scary reviews I read, this drug was recommended by my neurologist and it worked great for me. I'm an epileptic and when I can't sleep, I have seizures. Regular melatonin had stopped working for me, so my doctor prescribed this. The first night I took it,I slept like a rock!

5

Patient Review

9/7/2022

Rozerem for Chronic Trouble Sleeping

I was pleased with how well this product worked the very first night I took it. It wasn't like Ambien where you just knock out; rather, it helped me fall asleep gently and naturally.

5

Patient Review

5/24/2021

Rozerem for Difficulty Falling Asleep

I've been using this treatment nightly for about three weeks now, and it's really helped me get to sleep much faster. I would say it takes effect within minutes of taking it.

4.7

Patient Review

1/27/2019

Rozerem for Difficulty Falling Asleep

Rozerem is excellent! It took a few weeks to work as my doctor warned, but it's been amazing. I sleep so well now and feel great the next day with no hangover effects.

4.3

Patient Review

10/11/2022

Rozerem for Chronic Trouble Sleeping

I've had chronic insomnia for years, and was only able to find relief when I started taking Rozerem. It's expensive, but worth every penny to finally be able to get a good night's sleep.

2.7

Patient Review

12/8/2020

Rozerem for Chronic Trouble Sleeping

I was able to fall asleep with this drug, 8mg. However, it gave me nightmares and the following day I was groggy and dizzy. As a result, I will not be taking this again.

2.3

Patient Review

5/1/2017

Rozerem for Chronic Trouble Sleeping

I didn't experience any benefits from this treatment.

2.3

Patient Review

10/18/2021

Rozerem for Chronic Trouble Sleeping

My doctor recommended this to me because I have chronic fatigue and insomnia, but it didn't work at all for me. In fact, it made things worse!

2

Patient Review

5/25/2021

Rozerem for Chronic Trouble Sleeping

I am very disappointed with this medication. It did not help me sleep at all, and actually kept me awake. I'm writing this review at 6:25am after a sleepless night. In addition, it is quite expensive and Medicare does not approve payment for it.

1.7

Patient Review

10/26/2022

Rozerem for Difficulty Falling Asleep

Poor sleep quality. I was in bed for seven hours but my sleep tracker says I only slept for three. Definitely not worth it; wouldn't buy again.

1

Patient Review

4/26/2016

Rozerem for Difficulty Falling Asleep

I was already taking Ambian 5 mg. which worked just fine, but my insurance company stopped paying for it because I'm "too old." I don't think the insurance company is smarter than my doctor.

1

Patient Review

1/13/2019

Rozerem for Chronic Trouble Sleeping

I didn't get sufficient relief from this sleep medication, unfortunately. I woke up every few hours and had some really strange dreams while using it.

1

Patient Review

3/30/2022

Rozerem for Chronic Trouble Sleeping

Do not bother with this if you want to be able to function the next day. I took it last night and still can't sleep, even though it's now the afternoon. It kept me awake but in a state where I couldn't do anything else.

1

Patient Review

1/26/2019

Rozerem for Chronic Trouble Sleeping

Rozerem has been ineffective for me, actually causing longer falling asleep times and more frequent nighttime trips to the restroom. Discontinuing use.

1

Patient Review

1/3/2019

Rozerem for Chronic Trouble Sleeping

I took this treatment for five days and all it did was make me have to urinate more frequently. It also didn't help me sleep at all, so I stopped taking it and will be seeing my doctor to try something else.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about rozerem

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Rozerem similar to Ambien?

"Ramelteon is a sleep medication that helps people fall asleep by making it easier to fall asleep. It is not habit-forming and has fewer side effects than other sleep medications like zolpidem (Ambien), but may be more expensive."

Answered by AI

Is Rozerem a good sleeping pill?

"Ramelteon is a safe and effective way to help patients with chronic insomnia fall asleep and stay asleep. It does not have the potential for abuse or dependence that sedative hypnotics have, and is not classified as a controlled substance."

Answered by AI

Is Rozerem the same as melatonin?

"Rozerem is a medication that sends two specific melatonin-like signals to the brain's sleep center, which reduces the alerting signal at the time a person wants to go to sleep. This is in contrast to melatonin, which has widespread effects throughout the body."

Answered by AI