Synjardy

Q: Are Jardiance and Synjardy the same thing?

<p>Jardiance is a medication used to treat <a href="https://www.withpower.com/clinical-trials/type-2-diabetes">type 2 diabetes</a>. It is available as a standalone tablet or as a combination tablet with metformin. The medication works by helping the body to better use insulin. Side effects may include nausea, diarrhea, and headaches. Jardiance is a brand-name medication and costs can vary depending on insurance coverage.</p>

Congestive Heart Failure, Physical Activity, Monotherapy + 8 more

Treatment

6 FDA approvals

20 Active Studies for Synjardy

Treatment for

Congestive Heart Failure

What is Synjardy

EmpagliflozinThe Generic name of this drug

Treatment SummaryMetformin is a medication used to treat type 2 diabetes. It is the first-line drug of choice for managing type 2 diabetes and is taken by more than 120 million people around the world. Metformin lowers blood sugar levels without causing hypoglycemia, increases insulin sensitivity, and leads to modest weight loss. It was first approved in Canada in 1972 and in the United States in 1995. Metformin is available in regular and extended-release form.

Jardianceis the brand name

image of different drug pills on a surface

Synjardy Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Jardiance

Empagliflozin

2014

Approved as Treatment by the FDA

Empagliflozin, also called Jardiance, is approved by the FDA for 6 uses including Type 2 Diabetes Mellitus and Physical Activity .

Type 2 Diabetes Mellitus

Used to treat Type 2 Diabetes Mellitus in combination with Metformin

Physical Activity

Used to treat Exercise in combination with Metformin

Type 2 Diabetes

Used to treat Type 2 Diabetes Mellitus in combination with Metformin

Diet

Used to treat Diet in combination with Metformin

Cardiovascular Diseases

Cardiovascular Mortality

Effectiveness

How Synjardy Affects PatientsInsulin is a hormone that helps control the amount of sugar in the blood. People with Type II diabetes have a decreased sensitivity to insulin, which means their pancreas cannot keep up with regulating their sugar levels. Metformin works to reduce the amount of sugar produced by the liver and absorbed by the intestines, as well as increase the body's sensitivity to insulin. In a clinical trial, people taking Metformin had decreased fasting blood sugar levels by an average of 59 mg/dL, while those taking a placebo had increased levels by 6.3 mg/dL. Metformin also decreased HbA1c by 1

How Synjardy works in the bodyMetformin works in several ways to reduce blood glucose levels. It decreases the amount of glucose produced in the liver, decreases the amount of glucose absorbed from food in the intestines, and makes cells more sensitive to insulin. Metformin enters liver cells through a transporter called OCT1, and accumulates in the mitochondria. It blocks the production of energy in the mitochondria, turning on an enzyme called AMPK. This helps to decrease fat production and increase fat burning, as well as reduce glucose production in the liver. In the intestines, metformin increases anaerobic glucose metabolism, leading to less net glucose uptake and

When to interrupt dosage

The suggested dose of Synjardy is contingent upon the recognized disorder, including Diet, inadequate response to metformin and Diabetic Ketoacidosis. The quantity differs, in line with the methodology of delivery (e.g. Oral or Tablet - Oral) listed in the table below.

Condition

Dosage

Administration

Cardiovascular Diseases