Popular Trials
Cell Therapy
Islet Cell Transplant for Type 1 Diabetes
This trial is testing if it's safe to transplant human islet cells to help control blood sugar in type 1 diabetes patients who have trouble controlling it. Early observations will also be made about if this treatment can help with hypoglycemia.
Behavioural Intervention
Digital Health Management Tool for Type 1 Diabetes
This trial tests a digital tool that sends personalized text messages to help young adults manage their type 1 diabetes as they move to adult care. The tool provides support, education, and resources through SMS. It also collects feedback to measure its effectiveness.
Stem Cell Therapy
VX-880 for Type 1 Diabetes
This trial will test the safety and effectiveness of VX-880 infusion in people with Type 1 diabetes who have trouble sensing low blood sugar and experience severe low blood sugar episodes. The treatment aims to help manage their blood sugar levels better.
Monoclonal Antibodies
Teplizumab for Pediatric Type 1 Diabetes
This trial tests the safety of teplizumab, an IV medication, in children under 8 with early signs of type 1 diabetes. The drug aims to protect insulin-producing cells from immune system attacks and has shown potential in delaying the onset of type 1 diabetes.
Popular Filters
Trials for T1D Patients
Experimental Hyperglycemia for Type 1 Diabetes
This trial will study how T1D patients with normal awareness of hypoglycemia (NAH) respond to three 2-hour long hypoglycemic clamps. MRS will be used to measure neurochemical profiles before and after the clamps.
Mesenchymal Stem Cells
Stem Cell Therapy for Type 1 Diabetes
This trial is testing if special cells from umbilical cords can help young adults with Type 1 diabetes by calming their immune system and reducing inflammation. These cells pose a lesser risk of viral contamination due to low placental transmission during prenatal life.
Hormone Therapy
Gastrin + Islet Transplant for Type 1 Diabetes
This trial will evaluate if the combination of these two products can help patients with type 1 diabetes who have difficulty controlling their blood sugar levels with insulin make insulin again and improve blood sugar control.
Trials for Diabetes Patients
Behavioural Intervention
Diabetes App for Diabetes
This trial will test the feasibility, acceptability and effects of a diabetes app. Outcomes will measure behavior change, knowledge, distress, self-care, social support and clinical results. Focus groups will be used to evaluate acceptability.
Continuous Glucose Monitoring System
Continuous Glucose Monitoring for Diabetes
This trial is testing devices that monitor blood sugar levels in adults with diabetes and children with Type 1 Diabetes. The goal is to see how accurate and safe these devices are for managing diabetes. These devices allow people with diabetes to keep track of their blood glucose levels in near real-time.
Insulin
Inhaled Insulin for Diabetes in Children
This trial tests an inhalable insulin called Afrezza, combined with a long-acting insulin, in children and teenagers with diabetes. Afrezza helps lower blood sugar quickly after eating, and the long-acting insulin keeps it stable all day. The study aims to see if this combination is safe and effective.
Mesenchymal Stem Cell Therapy
Stem Cell Therapy for Chronic Kidney Disease
This trial is testing if using donor stem cells is safe and tolerable for people with chronic kidney disease. The stem cells might help repair their damaged kidneys. Stem cell therapy has shown potential in treating kidney diseases and aiding in kidney regeneration.
Maternal Enteroviral Infection and Diabetes Impact on Congenital Heart Defects
This trial is looking at the role of maternal viral infections in Congenital Heart Disease (CHD). They will be looking at samples from two existing biorepositories and also doing a prospective study.
Phase 3 Trials
Autoantigen-based Therapy
DIAGNODE-3 study for recently diagnosed type I diabetes
This trial tests if using Diamyd and Vitamin D can help young people and adults with Type 1 Diabetes. The goal is to help their bodies keep making insulin for longer. High dose vitamin D and omega 3 have shown promise in prolonging remission in Type 1 Diabetes.
Insulin
Inhaled Insulin for Diabetes in Children
This trial tests an inhalable insulin called Afrezza, combined with a long-acting insulin, in children and teenagers with diabetes. Afrezza helps lower blood sugar quickly after eating, and the long-acting insulin keeps it stable all day. The study aims to see if this combination is safe and effective.
Glucagon-like peptide-1 receptor agonist
Semaglutide for Type 1 Diabetes
This trial is testing semaglutide, a drug that helps with heart, kidney, and blood sugar health, in adults with type 1 diabetes. The drug has shown benefits for people with type 2 diabetes, but it is not yet approved for type 1 diabetes. Researchers want to see if it can provide similar health improvements for this new group. Semaglutide has been evaluated in numerous trials for its effectiveness in improving blood sugar levels and weight loss in type 2 diabetes.
Behavioral Intervention
Mindfulness-Based Intervention for Type 1 Diabetes
"This trial evaluates two virtual group interventions for teenagers with type 1 diabetes to improve their mental health and diabetes self-management. The study aims to see how these interventions can be used in diabetes clinics."
Glucagon-like peptide agonist
Liraglutide for Type 1 Diabetes
This trial will test the effect of liraglutide, a long-acting glucagon-like peptide-1 analog, on blood sugar control in adolescents with Type 1 diabetes. Liraglutide is already approved for the treatment of Type 2 diabetes in adults.
Trials With No Placebo
Experimental Hyperglycemia for Type 1 Diabetes
This trial will study how T1D patients with normal awareness of hypoglycemia (NAH) respond to three 2-hour long hypoglycemic clamps. MRS will be used to measure neurochemical profiles before and after the clamps.
Hormone Therapy
Gastrin + Islet Transplant for Type 1 Diabetes
This trial will evaluate if the combination of these two products can help patients with type 1 diabetes who have difficulty controlling their blood sugar levels with insulin make insulin again and improve blood sugar control.
Islet Cell Transplantation
Islet Cell Transplant for Type 1 Diabetes
This trial is testing whether islet transplantation is safe for people with Type 1 diabetes. Islets are clusters of cells that produce insulin, and the trial will use islets from cadaver donors.
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Frequently Asked Questions
Introduction to type 1 diabetes
What are the top hospitals conducting type 1 diabetes research?
When it comes to advancing the treatment and understanding of type 1 diabetes, several hospitals have emerged as leaders in groundbreaking clinical trials. In Minneapolis, the University of Minnesota has been at the forefront with seven ongoing trials focused on type 1 diabetes. With an impressive track record of 48 completed studies since their first recorded trial in 1983, this institution continues to contribute significantly to medical advancements in this field. Meanwhile, over on the East Coast in Boston, the renowned Joslin Diabetes Center is also making strides. They currently have seven active clinical trials centered around type 1 diabetes and boast an extensive portfolio of 59 completed studies dating back to their initial trial in 1994.
On the West Coast, Stanford University stands out with its contributions to research on type 1 diabetes. The institution currently has five active clinical trials dedicated to exploring new treatments for this condition. Since recording their first trial related to type 1 diabetes in 1994, they have accumulated a respectable total of 57 completed studies that have helped shape our understanding of this complex disease.
Heading southwards brings us to Gainesville where researchers at the University of Florida are hard at work conducting four current clinical trials related specifically to type one diabetes while having a countable tally adding up till forty-two prior conducted investigations since starting such pioneering efforts way back until1997.Moreover,the Canadian hospital situated at Edmonton namely;University Of Alberta despite being relatively smaller scale when it comes down merely three running projects for Type I Diabetes however makes notable contribution by paving path through twenty previously held similar investigations;having started as recently as early millennium committedly devoting themselves wholeheartedly since2002 focussing primarily upon providing innovative solutions like transplantation techniques or alternative insulin delivery methods
These esteemed institutions lead not only by example but also propel hope within individuals affected by Type I Diabetes worldwide.These progressive endeavours across continents highlights how every study carried out plays a crucial role towards combating the challenges posed by this condition and signifies dedication to enhance quality of life for those living with Type I Diabetes.
Which are the best cities for type 1 diabetes clinical trials?
When it comes to type 1 diabetes clinical trials, several cities have emerged as leading hubs of research and innovation. Boston, Massachusetts takes the lead with 10 active trials investigating treatments like Afrezza (Technosphere Insulin) + insulin degludec, VX-880, and IMCY-0098 450 μg. Montreal, Quebec closely follows with 9 ongoing studies exploring interventions such as Group education sessions for parents plus usual diabetes care and Rapid-Acting Insulin. Aurora, Colorado also stands out with its focus on Semaglutide, teplizumab, and Antithymocyte globulin (ATG) in their 9 active trials. These cities offer individuals living with type 1 diabetes access to cutting-edge clinical trials that hold promise for improved management and potential breakthroughs in care.
Which are the top treatments for type 1 diabetes being explored in clinical trials?
Exciting advancements are underway in clinical trials for type 1 diabetes, with several promising treatments taking center stage. Intraportal infusion of islet cells has emerged as a frontrunner, currently being explored in three active trials and four all-time trials since its introduction in 2003. Another noteworthy contender is intervention therapy, which shows promise with two ongoing trials and one previous trial recorded since 2017. Additionally, semaglutide is making waves in the research landscape, currently under investigation in two active studies and having participated in three type 1 diabetes trials overall since its initial listing last year. These innovative approaches bring hope to individuals living with type 1 diabetes while researchers continue their tireless efforts to uncover new breakthroughs.
What are the most recent clinical trials for type 1 diabetes?
Recent clinical trials have brought new hope for individuals with type 1 diabetes. One noteworthy trial investigated the use of Ritlecitinib, a medication in Phase 2 development, which demonstrated potential benefits for managing the condition. Another promising study focused on ZT-01 7 mg, also in Phase 2 testing, showing promise as a treatment option. Additionally, an ongoing Phase 4 trial evaluated the combined use of Afrezza (Technosphere Insulin) and insulin degludec to optimize blood sugar control in type 1 diabetes patients. These advancements offer optimism for improved management and quality of life for those living with this chronic disease.
What type 1 diabetes clinical trials were recently completed?
Several groundbreaking clinical trials for type 1 diabetes have recently come to a close, bringing hope and potential advancements in the treatment of this chronic condition. Eli Lilly and Company's trial on Lyumjev concluded in February 2022, while CRISPR Therapeutics AG wrapped up their study on VCTX210A unit just a month prior in January 2022. In June 2021, Youngene Therapeutics Inc., Ltd.'s trial on YG1699 reached completion. Earlier milestones include Novo Nordisk A/S's exploration of insulin icodec in April 2021 and Mayo Clinic's investigation into Pneumovax 23- pneumococcal polysaccharide during that same period. These recent achievements reflect the dedication of researchers committed to advancing our understanding and management of type 1 diabetes.