Algorithm-Supported Lipid Management for Atherosclerosis

(OPTIMIZE ASCVD Trial)

Overseen By Marc Bonaca, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Colorado Prevention Center

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

100 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This is a randomized, controlled, collaborative, multicenter, pilot implementation science study evaluating the hypothesis that algorithm- and multi-professional team-supported lipid management reduces low density lipoprotein-cholesterol (LDL-C) compared with usual care in patients with atherosclerotic cardiovascular disease (ASCVD).

Who Is on the Research Team?

Marc Bonaca, MD

Principal Investigator

Colorado Prevention Center

Are You a Good Fit for This Trial?

Inclusion Criteria

I have heart or blood vessel disease and my LDL cholesterol is over 70mg/dL.

Provided informed consent

I am over 18 years old.

Exclusion Criteria

Any reason that, in the opinion of the investigator, the patient would be unable to adhere to the protocol for the duration of the study (e.g. terminal diagnosis, metastatic cancer) or in whom participation might result in harm

I am adjusting my current cholesterol medication.

I have not had a heart attack or any artery-opening procedures in the last 30 days.

What Are the Treatments Tested in This Trial?

Interventions

• Algorithm- and multi-professional team-supported lipid management
• Guideline-directed lipid management by usual care provider

How Is the Trial Designed?

Group I: Control: Guideline-directed lipid management by usual care provider Experimental Treatment 1 Intervention

Group II: Algorithm- and multi-professional team-supported lipid management Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

Colorado Prevention Center

Lead Sponsor

Trials

13

Recruited

22,600+