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Nivolumab + Ipilimumab for Lung Cancer (ATLAS Trial)
ATLAS Trial Summary
This trial will test the effectiveness of two drugs, nivolumab and ipilimumab, for treating non-small cell lung cancer that has metastasized.
ATLAS Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowATLAS Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.ATLAS Trial Design
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Who is running the clinical trial?
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- I am not incarcerated and can consent and follow study procedures.I haven't taken immunosuppressive drugs in the last 14 days, with some exceptions.I have not had any treatment for my current lung cancer diagnosis.I've had to stop IV drug treatments more than once due to bad reactions.I haven't had cancer treatment or palliative radiotherapy in the last 3 weeks.I have previously received immunotherapy.I have had an autoimmune disorder in the last 3 years.All my side effects from previous treatments, except for hair loss, have gone back to normal.I do not have any severe illnesses or social situations that would prevent me from following the study's requirements.My lung cancer has returned or spread to other parts.My lung cancer can be of any type.My surgery did not remove all of my cancer.My tumor's PDL1 level is below 50%.I haven't had a heart attack, stroke, or severe heart failure in the last 3 months.My cancer does not have mutations like EGFR, ALK, or ROS1.I have a history of immune system issues, organ transplant, or active tuberculosis.I have not had any other cancer besides non-invasive types in the last 2 years.You have HIV, chronic or active hepatitis B or C, or active hepatitis A.I haven't had a live vaccine or major surgery in the last 30 days.You are expected to live for at least 12 more weeks.I weigh at least 35 kilograms.I am fully active or can carry out light work.I am not pregnant, breastfeeding, nor plan to become pregnant during the study.My organs and bone marrow are working well.I am 18 years old or older.
- Group 1: Non-Small cell Lung Cancer
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any historical records of Ipilimumab being tested in a research setting?
"Currently, 918 clinical trials are active, with 144 being in the third phase. Most of these studies take place in Xiamen, Fujian; however there is a large presence of studies for Ipilimumab distributed across 59,988 different locations worldwide."
Are there any vacancies currently available for participation in this trial?
"Affirmative. Per the information on clinicaltrials.gov, this medical trial has been looking for patients since January 24th 2022 and is actively recruiting as of May 9th 2021. The goal is to sign up 50 individuals at 1 site."
To what extent could Ipilimumab be detrimental to patients?
"Ipilimumab has been evaluated in a Phase 2 clinical trial, meaning there is evidence of safety but not necessarily efficacy. Thus our team at Power assessed the drug's safety on a scale from 1 to 3 and gave it a score of 2."
What conditions are usually managed with Ipilimumab?
"Ipilimumab is a commonly employed anti-angiogenic treatment, and has also been found to be an effective therapeutic option for individuals with malignant neoplasms, unresectable melanoma, and squamous cell carcinoma."
Approximately how many subjects are participating in this trial?
"Correct. Clinicaltrials.gov corroborates that this research project, originally posted on January 24th 2022 is currently recruiting participants. The trial requires 50 subjects from 1 site to be enrolled in the study."
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