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Mental Health Program for People Living With HIV (ORCHID Trial)
Phase 2
Recruiting
Research Sponsored by Northwestern University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Age 18 and over
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights
No Placebo-Only Group
Summary
This trial tests an online program called ORCHID that helps people living with HIV who are depressed. The program teaches skills to boost positivity and manage stress. The goal is to see if it improves mental health and helps patients stick to their HIV treatment.
Who is the study for?
This trial is for adults over 18 living with HIV in Chicago, who are clients at Ryan White clinics and show signs of depression. Participants must speak English, have daily internet access, and agree to share their health information.
What is being tested?
The study tests a mental health intervention called ORCHID delivered online to improve mood and health outcomes in HIV patients. It involves screening for depression and providing resources through case managers using a stepped wedge design.
What are the potential side effects?
Since ORCHID is a psychological support program delivered online, it may not have direct medical side effects but could include emotional discomfort or distress as participants engage with the content.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am 18 years old or older.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Depression
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Behavioral Health Screener + ORCHID Intervention (BHS+ORCHID)Experimental Treatment1 Intervention
At the clinic level, sites randomized to implement BHS+ORCHID will receive training, materials, and other support to administer behavioral health screening and refer their clients with elevated depression symptoms to ORCHID.
At the individual level, those clients who are eligible and choose to enroll in ORCHID will receive self-guided training on 8 positive affect skills through weekly online sessions and daily practice exercises.
Group II: Standard of CareActive Control1 Intervention
usual care
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
The ORCHID trial aims to improve mental health and viral suppression in People Living With HIV (PLWH) by increasing positive affect through an online-delivered intervention. Common treatments for PLWH include antiretroviral therapy (ART), which works by inhibiting the replication of the HIV virus, thereby reducing viral load and improving immune function.
Increasing positive affect is crucial as it is associated with better adherence to ART, lower levels of depression, and slower disease progression. This holistic approach not only targets the virus but also enhances psychological well-being, leading to better overall health outcomes for PLWH.
A Qualitative Study to Identify Perceptual Barriers to Antiretroviral Therapy (ART) Uptake and Adherence in HIV Positive People from UK Black African and Caribbean Communities.
A Qualitative Study to Identify Perceptual Barriers to Antiretroviral Therapy (ART) Uptake and Adherence in HIV Positive People from UK Black African and Caribbean Communities.
Find a Location
Who is running the clinical trial?
AIDS Foundation of ChicagoUNKNOWN
AIDS Foundation ChicagoUNKNOWN
University of ChicagoOTHER
1,043 Previous Clinical Trials
758,207 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- You are able to speak and understand English.You are currently receiving medical care at one of the approved Ryan White clinics.Your PHQ-9 score is higher than 5, indicating you may be experiencing depression, and you were referred by your medical case manager.I am 18 years old or older.You have access to the internet every day using a device.You agree to receive medical care and allow the study team to access your health information from the Chicago Department of Health, your primary care provider, and/or the AIDS Foundation Chicago.You must live near the Ryan White clinic in the Chicago area.The clinical trial site must have medical services available to you.
Research Study Groups:
This trial has the following groups:- Group 1: Behavioral Health Screener + ORCHID Intervention (BHS+ORCHID)
- Group 2: Standard of Care
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
People Living With HIV Patient Testimony for trial: Trial Name: NCT05123144 — Phase 2
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