Cognitive Remediation for Memory Loss
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new facial expression-based tool (FPE) designed to help people adhere to at-home brain training exercises. It focuses on older adults at risk for Alzheimer's disease or related memory issues. The trial compares two groups: one using the brain training with the new tool and the other without it, to determine if the tool enhances engagement and memory over time. This trial may suit individuals aged 60-89 who live independently and have stable memory medication. As a Phase 1 trial, the research aims to understand how the treatment works in people, offering participants the chance to be among the first to experience this innovative approach.
Will I have to stop taking my current medications?
You don't have to stop taking your current medications, but they need to be stable. Anti-depressants, antipsychotics, and anxiolytics should be stable for at least 7 days, and memory medications should be stable for at least 3 months before joining the trial.
What prior data suggests that this facial expression-based personalization engine is safe for older adults at risk for Alzheimer's disease?
Research suggests that personalized cognitive training can improve brain function in older adults, potentially enhancing speed and efficiency. Other studies have shown that this training can enhance memory and thinking skills in older individuals with memory concerns.
The trial tests a new system that engages participants using facial expressions. Although specific safety data for this system is not yet available, some safety insights can be gathered. As a Phase 1/Phase 2 trial, researchers are still assessing the system's safety for participants. Treatments in these early phases are closely monitored to ensure minimal risks.
Overall, while the personalized system is new, basic cognitive training has shown promise in being safe and beneficial for older adults.12345Why are researchers excited about this trial?
Researchers are excited about the cognitive remediation treatments for memory loss because they use a personalized engine to tailor cognitive training specifically to each individual. Unlike standard treatments like medication or generic brain exercises, this approach adapts in real-time to the user's needs, potentially enhancing effectiveness. The personalized training promises a more engaging and efficient way to address memory issues, making it a promising alternative to traditional methods.
What evidence suggests that this facial expression-based personalization engine is effective for enhancing adherence in cognitive training for older adults at risk for Alzheimer's disease?
Research has shown that personalized brain training can enhance skills such as thinking speed, focus, and memory. One study found that participants who completed this training performed better in daily tasks and mental tests. Another study noted improvements in decision-making and brain efficiency. In this trial, participants will join one of two groups: one receiving unsupervised cognitive training with a personalized engine, and the other without it. The personalized engine uses a special tool that monitors facial expressions to maintain interest among older adults and enhance the exercises' effectiveness. This tool adjusts the training based on expressions to keep it engaging and improve results. These findings suggest that this approach could boost mental abilities in individuals at risk for Alzheimer's disease and similar conditions.36789
Are You a Good Fit for This Trial?
This trial is for older adults at risk for Alzheimer's disease or related dementias who can participate in unsupervised, computerized cognitive training. Participants should be able to adhere to the training regimen and have no conditions that would interfere with their ability to engage with the software.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo unsupervised cognitive training with or without the facial expression-based personalization engine (FPE) for 6 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of memory and executive function
What Are the Treatments Tested in This Trial?
Interventions
- FPE
Find a Clinic Near You
Who Is Running the Clinical Trial?
Stanford University
Lead Sponsor