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Lifestyle Changes for Glaucoma

N/A
Waitlist Available
Led By Karen Joos, MD,PhD
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients with normal-pressure glaucoma
Patients with open-angle glaucoma
Timeline
Screening 3 weeks
Treatment Varies
Follow Up within 1 day
Awards & highlights

Study Summary

This trial is testing if increased pressure in the eye affects its stability.

Who is the study for?
This trial is for individuals with open-angle glaucoma or normal-pressure glaucoma, as well as those with autonomic dysfunction. Healthy people can also join. Medical students, prisoners, and pregnant women are not eligible to participate.Check my eligibility
What is being tested?
The study investigates how drinking water and changing body posture might affect the pressure inside the eye (IOP) in people with different types of glaucoma or autonomic dysfunction compared to healthy individuals.See study design
What are the potential side effects?
Since this trial involves non-invasive interventions like drinking water and postural changes, side effects may be minimal but could include discomfort from eye pressure measurements or dizziness upon standing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with normal-pressure glaucoma.
Select...
I have open-angle glaucoma.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~within 1 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and within 1 day for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in Intraocular Pressure

Trial Design

4Treatment groups
Experimental Treatment
Active Control
Group I: Subjects with normal-pressure glaucomaExperimental Treatment2 Interventions
Subjects with open-angle glaucoma damage following a glaucoma specialist's examination without ever an intraocular pressure recording greater than 21 mm Hg. .1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.
Group II: Subjects with autonomic dysfunctionExperimental Treatment2 Interventions
Subjects with known autonomic dysfunction diagnoses as defined by the General Clinical Research Center (GCRC) such as pure autonomic failure, Postural orthostatic tachycardia syndrome (POTS), and Multiple System Atrophy( MSA). Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.
Group III: Primary open-angle glaucoma subjectsExperimental Treatment2 Interventions
Subjects diagnosed with primary open-angle glaucoma following a glaucoma specialist's examination. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.
Group IV: Normal subjectsActive Control2 Interventions
Subjects without evidence of glaucoma or autonomic dysfunction. ..1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor
850 Previous Clinical Trials
668,927 Total Patients Enrolled
Karen Joos, MD,PhDPrincipal InvestigatorVanderbilt Eye Institute

Media Library

Postural change Clinical Trial Eligibility Overview. Trial Name: NCT00338065 — N/A
Glaucoma Research Study Groups: Subjects with autonomic dysfunction, Normal subjects, Subjects with normal-pressure glaucoma, Primary open-angle glaucoma subjects
Glaucoma Clinical Trial 2023: Postural change Highlights & Side Effects. Trial Name: NCT00338065 — N/A
Postural change 2023 Treatment Timeline for Medical Study. Trial Name: NCT00338065 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What criteria must be met to partake in this research study?

"This clinical research is seeking 200 individuals aged between 10 and 90 years old who have intraocular pressure (IOP). Additionally, those wishing to participate must meet additional qualifications such as having autonomic dysfunction, open-angle glaucoma or being a normal subject."

Answered by AI

Does this experiment allow for the participation of octogenarians?

"According to the selection criteria for this clinical trial, participant must be between 10 and 90 years old."

Answered by AI

Are participants being taken for this experiment right now?

"Clinicaltrials.gov has reported that this medical research project, which was initially listed on June 1 2006 and updated lastly in March 29 2022, is not currently enrolling patients. However, there are 9 other clinical trials with open enrollment at the present time."

Answered by AI
~34 spots leftby Dec 2027