This trial is evaluating whether Usual Care will improve 1 primary outcome and 4 secondary outcomes in patients with Latent Tuberculosis. Measurement will happen over the course of Up to 6 months.
This trial requires 399 total participants across 3 different treatment groups
This trial involves 3 different treatments. Usual Care is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"A major obstacle to treatment of latent tuberculosis is the lack of an effective drug regimen in combination with reliable tests to monitor treatment. Current treatment regimens, such as monthly short courses of rifampicin and pyrazinamide, have poor treatment outcomes, but a more effective approach is to target treatment directly to people with TB disease and to develop novel drugs against dormant M. tuberculosis." - Anonymous Online Contributor
"The exact cause of latent tuberculosis is not well known. It occurs when the bacilli that cause tuberculosis get trapped in the lymph nodes or lymphatics for years after infection. However, it is not clear why some individuals get latent while others do not. It is possible that different genes make some people more likely to develop either the active or latent forms of disease. On the other hand the risk of getting tuberculosis depends largely on environmental factors such as where an individual lives and where they spend most of their time." - Anonymous Online Contributor
"There is an alarming number of individuals new or formerly treated for tuberculosis and who have never received treatment. A high rate of these individuals has not been diagnosed or treated. A screening program of patients diagnosed with tuberculosis may help identify undetected new cases of tuberculosis that can be treated." - Anonymous Online Contributor
"The main clinical symptoms of LTBI included erythema induratum perpetuum, erythema nodosum, and a skin disease resembling leprosy. Patients with a positive tuberculin skin test, but who lacked clinical and histopathological evidence of tuberculosis, usually do well without treatment. However, such patients have a considerable risk of developing active tuberculosis at any time, and should therefore be treated as high-risk individuals with the most effective antituberculous medications." - Anonymous Online Contributor
"In addition to its obvious consequences for health and human dignity, TB can conceal or masquerade itself as more common ailments including heart disease and high blood pressure. The disease should be considered as a serious public health concern and preventive measures taken." - Anonymous Online Contributor
"Data from a recent study, as reported in the press following the publication of its initial results in August 2012, shows that patients with active tuberculosis, regardless of their localization at admission and their treatment history, can clear latent tuberculosis infection. Furthermore, patients with a favorable prognosis (mortality was less than 1% with successful treatment) experienced good recovery from active disease." - Anonymous Online Contributor
"These data suggest that a significant proportion of patients are not treated at all with medications or DOTS. Despite this, DOTS remains the most widely used strategy for treating tuberculosis. Although VDOT appears to be more expensive, it offers an important advantage of providing patients access to treatment." - Anonymous Online Contributor
"Results from a recent clinical trial support the concept of a genetic component to disease susceptibility in families of patients with TB, and suggest that the disease-producing agents of TB may have a role in the regulation of immune functions." - Anonymous Online Contributor
"In most instances, VADT+ FIT+ provides similar health outcomes to conventional care. Nonetheless, a randomized trial of VADT+ FIT+ among patients with M. tuberculosis-associated disease would help us more fully understand the value and risks of VADT+ FIT compared to TST+ referrals to public health tuberculosis programs in this setting." - Anonymous Online Contributor
"In South Korea, we find no evidence of this practice being widely used. Some of these trials did not use VDOT. Future research is needed to determine how frequently this technique is being used outside of South Korea." - Anonymous Online Contributor
"It is more common for individuals to acquire latent tuberculosis due to their exposure to other people's secretions rather than environmental exposure. The transmission is commonly from people with active tuberculosis. The exact cause of latent tuberculosis cases is unknown. Doctors recommend that all people with Latent tuberculosis be treated every two weeks until latent tuberculosis is no longer contagious (4 weeks) to prevent or reduce chances of re-transmission. To find the exact cause of latent tuberculosis, visit the Power site." - Anonymous Online Contributor