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Chemotherapy

AZD2811 for Small Cell Lung Cancer (TAZMAN Trial)

Phase 2
Waitlist Available
Research Sponsored by AstraZeneca
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up approximately 3 years
Awards & highlights

TAZMAN Trial Summary

This trial is testing a combination of two drugs, AZD2811 and durvalumab, as a potential treatment for extensive stage small-cell lung cancer.

Eligible Conditions
  • Small Cell Lung Cancer

TAZMAN Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~approximately 3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and approximately 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Maintenance participants alive and progression free (APF12) per RECIST 1.1 [Efficacy]
Secondary outcome measures
AZD2811 PK: Pharmacokinetics of AZD2811 and its metabolites by measuring whole blood concentration
Assess safety and tolerability profile in terms safety assessments, adverse events per National Cancer Institute (NCI) Common Terminology Criteria for Adverse Event [CTCAE] v5.0, and dose modifications
Cmax of durvalumab
+8 more

TAZMAN Trial Design

1Treatment groups
Experimental Treatment
Group I: AZD2811 + DurvalumabExperimental Treatment5 Interventions
Induction: Durvalumab + Platinum Chemotherapy (Carboplatin or cisplatin & Etoposide) Maintenance: AZD2811 + Durvalumab
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Carboplatin
2014
Completed Phase 3
~6670
Durvalumab
2017
Completed Phase 2
~3870
AZD2811
2015
Completed Phase 1
~80
Etoposide
2010
Completed Phase 3
~2440
Cisplatin
2013
Completed Phase 3
~1940

Find a Location

Who is running the clinical trial?

AstraZenecaLead Sponsor
4,253 Previous Clinical Trials
288,538,152 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are currently enrolled in this trial?

"This medical trial is no longer recruiting patients, as the last update was on September 9th 2022. If you are hoping to get involved in other clinical trials, there are 1577 studies involving small cell lung carcinoma and 1534 triasl researching AZD2811 that have open enrolment procedures."

Answered by AI

What is the geographical breadth of this trial's implementation?

"Currently, 6 locations are accepting participants for this clinical trial. These include Montreal, Boston and Houston as well as other cities in proximity to those three. To minimize the need for travel, we recommend selecting a site near your location if you choose to enroll."

Answered by AI

What conditions is AZD2811 most commonly utilized for?

"AZD2811 is regularly administered to individuals suffering from Hodgkin's disease, yet can be prescribed for additional severe illnesses such as malignant pleural mesothelioma and advanced head/neck cancer."

Answered by AI

What precedent exists for the efficacy of AZD2811 in medical research?

"At present, there are 1,534 ongoing studies for AZD2811 with 442 of them in the advanced Phase 3. In addition to Shanghai's extensive involvement in these trials, 79345 other sites across the globe are conducting research on this medication."

Answered by AI

Are researchers currently enrolling participants in this experiment?

"This research study is no longer accepting participants. It was originally published on February 23rd 2021 and last updated September 9th 2022. Fortunately, there are plenty of other clinical trials seeking individuals with small cell lung carcinoma; 1577 studies in total, as well as 1,534 for AZD2811."

Answered by AI

Has the regulatory body approved AZD2811 for public use?

"This medication has been assessed to have a safety rating of 2 out of 3 given that it is in the Phase 2 trial stage and there exists some evidence attesting to its security but no proof yet for efficacy."

Answered by AI
~8 spots leftby Apr 2025