Geniculate Artery Embolization for Osteoarthritis, Knee

Phase-Based Progress Estimates

Effectiveness

Safety

Osteoarthritis, Knee+3 More

Geniculate Artery Embolization - Device

You have a chance of qualifying for this trial. We made sure your application will take less than 5 minutes.

Eligibility

18+

All Sexes

What conditions do you have?

Select

Eligibility

18+

All Sexes

What conditions do you have?

Select

Study Summary

This trial is testing a new way to treat osteoarthritis that doesn't involve surgery. They will compare it to the standard of care to see if it is better.

Eligible Conditions

Osteoarthritis, Knee
Knee
Arthrosis
Arthritis

Treatment Effectiveness

Effectiveness Progress

1 of 3

Similar Trials

Rehabilitation

Phase 1:Best Practices + Duloxetine + Pain coping skills

Geniculate nerve ablation

Study Objectives

1 Primary · 8 Secondary · Reporting Duration: baseline, 1 month, 6 months, 12 months

12 months

Feasibility as Assessed by Protocol Adherence

Feasibility as Assessed by Recruitment Rate

Safety as Assessed by Grade 3-4 Adverse events

Month 12

C-Reactive Protein Concentration

Erythrocyte Sedimentation Rate

IL-6 Concentration

Matrix Metalloprotinase 1 Concentration

Prostaglandin E2 Concentration

Vascular Endothelial Growth Factor Concentration

Month 12

Change in Knee Injury and Osteoarthritis Outcome Score (KOOS)

Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)

Trial Safety

Safety Progress

1 of 3

Similar Trials

Rehabilitation

Phase 1:Best Practices + Duloxetine + Pain coping skills

Geniculate nerve ablation

Trial Design

2 Treatment Groups

Standard of Care

1 of 2

GAE + Standard of Care

1 of 2

Active Control

Experimental Treatment

20 Total Participants · 2 Treatment Groups

Primary Treatment: Geniculate Artery Embolization · No Placebo Group · N/A

GAE + Standard of Care

Device

Experimental Group · 1 Intervention: Geniculate Artery Embolization · Intervention Types: Device

Standard of CareNoIntervention Group · 1 Intervention: Standard of Care · Intervention Types:

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Geniculate Artery Embolization

2018

N/A

~50

Trial Logistics

Trial Timeline

Screening: ~3 weeks

Treatment: Varies

Reporting: baseline, 1 month, 6 months, 12 months

Who is running the clinical trial?

University of MinnesotaLead Sponsor

1,239 Previous Clinical Trials

1,460,622 Total Patients Enrolled

3 Trials studying Osteoarthritis, Knee

131 Patients Enrolled for Osteoarthritis, Knee

Jafar Golzarian, MDPrincipal InvestigatorUniversity of Minnesota

3 Previous Clinical Trials

379 Total Patients Enrolled

Reza Talaie, MDPrincipal InvestigatorUniversity of Minnesota

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:

You have symptomatic osteoarthritis of the knee, and radiographic evidence of OA in the same knee.

You have a radiograph of the knee that shows one or more of the following: a.

You are willing to comply with the protocol requirements and willing to undergo non-contrast MRI 1-30 days prior to procedure and at 12 months following procedure.

You are willing to comply with regular follow-up during the 12 month follow-up period.

About The Reviewer

Michael Gill - B. Sc.

First Published: October 31st, 2021

Last Reviewed: November 26th, 2022

Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.

References