Diclofenac Gel for Osteoarthritis
Trial Summary
What is the purpose of this trial?
The goal of this clinical trial is to understand the patient and clinic visit characteristics that affect health outcomes for individuals with knee osteoarthritis (OA) pain using topical diclofenac gel. The main questions it aims to answer are:* What baseline patient characteristics predict response to topical diclofenac?* Does patient physiology during the study visit predict response to topical diclofenac?* Do study visit characteristics predict response to topical diclofenac?Participants will:* attend 2 study visits to complete study questionnaires and have blood drawn* apply topical diclofenac to their knee for 8 weeks* complete biweekly questions about knee pain and diclofenac use between study visits
Research Team
Michelle Dossett, MD, PhD, MPH
Principal Investigator
University of California, Davis
Eligibility Criteria
This trial is for individuals with knee osteoarthritis who are willing to apply diclofenac gel on their knee and can attend two study visits. Participants will also need to answer biweekly questions about their knee pain and treatment usage.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Initial Study Visit
Participants attend the first study visit to complete baseline questionnaires, have blood drawn, and receive diclofenac gel
Treatment
Participants apply topical diclofenac to their knee for 8 weeks and complete biweekly questions about knee pain and diclofenac use
Follow-up
Participants attend a follow-up visit to complete final questionnaires and assess outcomes
Treatment Details
Interventions
- Topical Diclofenac gel
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor
Beth Israel Deaconess Medical Center
Collaborator
National Institute on Aging (NIA)
Collaborator