Micafungin
Candidemia, prophylaxis of Esophageal candidiasis, Aspergillosis + 10 more
Treatment
11 FDA approvals
20 Active Studies for Micafungin
Treatment for
Candidemia
What is Micafungin
Micafungin
The Generic name of this drug
Treatment Summary
Micafungin is a medication used to treat fungal infections. It works by blocking the production of an essential component of the cell wall of fungi, called 1,3-beta-D-glucan.
Mycamine
is the brand name
Micafungin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Mycamine
Micafungin
2005
23
Approved as Treatment by the FDA
Micafungin, otherwise known as Mycamine, is approved by the FDA for 11 uses including Candidiasis and Systemic candidiasis .
Candidiasis
Systemic candidiasis
Meningoencephalitis
prophylaxis of Candida Infections
Bone Marrow Transplant
Candidemia
Peritonitis
Yeast Infection
Meningoencephalitis
Esophageal Candidiasis
Abscess
Effectiveness
How Micafungin Affects Patients
Micafungin, formerly known as FK463, is a medicine that fights off fungal infections. It works by blocking an enzyme in the fungus that helps build its cell wall. Depending on how much of the medicine is taken, it can either stop the fungus from growing (fungistatic) or kill it (fungicidal). Micafungin can be taken with other medicines, such as HIV drugs and transplant medicines.
How Micafungin works in the body
Micafungin prevents fungi from forming cell walls by blocking a compound, called beta-1,3-D-glucan synthase, that the fungi needs to build the walls. This compound isn't found in humans, so our cells are not affected.
When to interrupt dosage
The recommended quantity of Micafungin is contingent upon the identified condition, which may include Infections, Fungal, Candida (fungus) and Abscesses. The amount likewise varies as per the technique of delivery (e.g. Injection, powder, lyophilized, for solution - Intravenous or Intravenous) featured in the table beneath.
Condition
Dosage
Administration
prophylaxis of Esophageal candidiasis
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Aspergillosis
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
prophylaxis of moderate Pneumocystis pneumonia
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Yeast Infection
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
prophylaxis of Candida Infections
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
HIV Positive
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Abscess
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
HIV
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Esophageal Candidiasis
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Bone Marrow Transplant
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Peritonitis
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Meningoencephalitis
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Candidemia
, 50.0 mg, 100.0 mg, 20.0 mg/mL, 10.0 mg/mL, 100.0 mg/mL, 50.0 mg/mL
, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Warnings
Micafungin Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 16 known major drug interactions with Micafungin.
Common Micafungin Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Moderate
The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Micafungin.
(S)-Warfarin
Moderate
The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Micafungin.
4-hydroxycoumarin
Moderate
The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Micafungin.
Acenocoumarol
Moderate
The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Micafungin.
Clorindione
Moderate
The therapeutic efficacy of Clorindione can be increased when used in combination with Micafungin.
Micafungin Toxicity & Overdose Risk
The toxic dose of Diflucan for rats is 125mg/kg. In dogs, the toxic dose is higher than 200mg/kg. So far, no reports of overdose have been made. In clinical trials, adults have taken up to 8mg/kg of Diflucan per day with no severe side effects. The lowest dose that could be fatal to rats is 125mg/kg, which is 8.1 times the usual dose given to humans with esophageal candidiasis.
Micafungin Novel Uses: Which Conditions Have a Clinical Trial Featuring Micafungin?
459 active experiments are being conducted to assess the suitability of Micafungin for Candida (fungus), Abscesses and Peritonitis treatment.
Condition
Clinical Trials
Trial Phases
HIV
153 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
HIV Positive
0 Actively Recruiting
Esophageal Candidiasis
0 Actively Recruiting
Aspergillosis
0 Actively Recruiting
Peritonitis
0 Actively Recruiting
prophylaxis of Candida Infections
0 Actively Recruiting
Bone Marrow Transplant
27 Actively Recruiting
Not Applicable, Phase 2, Early Phase 1, Phase 1
Yeast Infection
0 Actively Recruiting
Meningoencephalitis
0 Actively Recruiting
Abscess
0 Actively Recruiting
prophylaxis of Esophageal candidiasis
0 Actively Recruiting
prophylaxis of moderate Pneumocystis pneumonia
0 Actively Recruiting
Candidemia
3 Actively Recruiting
Phase 3, Phase 2
Patient Q&A Section about micafungin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How long do you take micafungin?
"In patients who were successfully treated with micafungin, the average duration of therapy was 15 days, with a range of 10 to 30 days."
Answered by AI
What is micafungin used for?
"Micafungin is used to treat candidemia, acute disseminated candidiasis, candida peritonitis and abscess, and esophageal candidiasis."
Answered by AI
Is micafungin an antibiotic?
"Micafungin sodium is an antifungal medication used to treat and prevent infections caused by the Candida fungus."
Answered by AI
What kind of drug is micafungin?
"This medication can be used to treat a variety of fungal infections and to prevent fungal infections in patients who are going through a stem cell transplant. Micafungin works by stopping the growth of fungi and belongs to a class of drugs known as echinocandins."
Answered by AI