Oravig

Inflammation, Tinea Pedis, Dermatophytosis + 20 more

Treatment

20 Active Studies for Oravig

What is Oravig

Miconazole

The Generic name of this drug

Treatment Summary

Miconazole is an antifungal medication used to treat yeast infections of the mucous membranes, in both the mouth and vagina. It is available in a variety of prescription and non-prescription forms, such as creams, gels, and tablets. The drug works by inhibiting the activity of a certain enzyme in fungi, which helps stop the spread of the infection. Miconazole has been available since 1974 and is generally well tolerated with low risk of resistance.

SUNMARK MICONAZOLE NITRATE antifungal

is the brand name

image of different drug pills on a surface

Oravig Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

SUNMARK MICONAZOLE NITRATE antifungal

Miconazole

1991

255

Effectiveness

How Oravig Affects Patients

Miconazole is a medicine used to treat fungal infections. It works by blocking a certain enzyme that helps the fungus grow. When applied directly to the skin, it is not absorbed into the body and usually does not cause any side effects. However, people who use miconazole for intravaginal use should not use tampons or rely on contraceptives to prevent pregnancy or infection.

How Oravig works in the body

Miconazole works in several ways to fight fungal infections. It blocks an enzyme that helps create the cell membrane of fungi, making it harder for them to survive. It also makes it harder for fungi to produce energy and survive in the body. Miconazole also causes fungi to produce a molecule called farnesol, which inhibits their ability to form biofilms, which are resistant to antibiotics. Lastly, farnesol stops fungi from pumping out drugs, making them more susceptible to miconazole.

When to interrupt dosage

The suggested measure of Oravig is based on the diagnosed condition, including Gastrointestinal candidiasis, Nail candida and Infection, Mixed. The dosage can be found in the table below and is contingent upon the approach of delivery (e.g. Topical or Aerosol, spray - Topical).

Condition

Dosage

Administration

Tinea Pedis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Dermatophytosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Arthrodermataceae

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Candidiasis, Vulvovaginal

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Acne Vulgaris

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Oropharyngeal Candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Ringworm

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Tinea Cruris

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Tinea

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Yeast Infection

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Dermatitis, Seborrheic

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Dermatitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Inflammation

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

cutaneous candidiasis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Onychomycosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Cellulitis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Coinfection

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Hyperhidrosis

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Intertrigo

, 0.02 mg/mg, 0.0206 mg/mg, 0.1 mg, 20.0 mg/mL, 0.002 mg/mg, 0.026 mg/mg, 0.04 mg/mg, 0.00002 mg/mg, 0.142 mg/mg, 0.0002 mg/mg, 200.0 mg/mg, 0.03 mg/mg, 0.013 mg/mg, 0.07 mg/mg, 0.0256 mg/mg, 0.02 mL/mL, 50.0 mg, 2.0 %, 400.0 mg, 1200.0 mg, 4.0 %, 100.0 mg, 0.03 mg/mL, 0.0025 mg/mg, 0.112 mg/mg, 0.0282 mg/mg, 200.0 mg, 0.02 mg/mL, 20.0 mg/mg, 40.0 mg, 0.1 mg/mg, 100.0 mg/mg, 0.06 mg/mg, 2.0 mg/mg, 0.2 mg/mg, 0.17 mg/mg

, Powder, Powder - Topical, Topical, Kit, Cream, Cream - Topical, Spray, Spray - Topical, Vaginal, Cream - Vaginal, Suppository - Vaginal, Suppository, Tincture, Tincture - Topical, Kit - Vaginal, Ointment, Ointment - Topical, Liquid, Liquid - Topical, Aerosol, spray, Aerosol, spray - Topical, Aerosol, powder - Topical, Aerosol, powder, Insert, Insert - Vaginal, Aerosol, Aerosol - Topical, Oral; Topical, Capsule; Cream; Kit - Oral; Topical, Capsule; Cream; Kit, Cream; Insert, Cream; Suppository, Topical; Vaginal, Cream; Insert - Topical; Vaginal, Tablet, Tablet - Buccal, Lotion, Lotion - Topical, Cream; Suppository - Topical; Vaginal, Kit - Topical, Buccal, Kit - Topical; Vaginal, Paste, Paste - Topical

Warnings

Oravig has two forbiddances and should not be used while encountering any of the conditions mentioned in the following table.

Oravig Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Miconazole may interact with Pulse Frequency

There are 20 known major drug interactions with Oravig.

Common Oravig Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Miconazole.

Abrocitinib

Major

The metabolism of Abrocitinib can be decreased when combined with Miconazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Miconazole.

Acetylsalicylic acid

Major

The metabolism of Acetylsalicylic acid can be decreased when combined with Miconazole.

Albendazole

Major

The metabolism of Albendazole can be decreased when combined with Miconazole.

Oravig Toxicity & Overdose Risk

Taking too much miconazole can lead to serious side effects such as headaches, skin irritation, diarrhea, nausea, vomiting, abdominal pain, and bad taste in the mouth. It is recommended that those who overdose on miconazole receive appropriate medical care and supportive measures. The lethal dose of miconazole for rats is 500mg/kg.

image of a doctor in a lab doing drug, clinical research

Oravig Novel Uses: Which Conditions Have a Clinical Trial Featuring Oravig?

203 active trials are underway to assess the potential of Oravig to alleviate Dermatophytosis, reduce Inflammation and abate Excessive Sweating and Body Odor.

Condition

Clinical Trials

Trial Phases

Inflammation

56 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 3, Phase 4

Yeast Infection

0 Actively Recruiting

Onychomycosis

0 Actively Recruiting

Acne Vulgaris

3 Actively Recruiting

Phase 1, Phase 2, Early Phase 1, Phase 4

Candidiasis

0 Actively Recruiting

Dermatitis, Seborrheic

0 Actively Recruiting

Dermatophytosis

0 Actively Recruiting

cutaneous candidiasis

0 Actively Recruiting

Cellulitis

0 Actively Recruiting

Tinea Versicolor

0 Actively Recruiting

Skin candida

0 Actively Recruiting

Tinea Pedis

0 Actively Recruiting

Arthrodermataceae

0 Actively Recruiting

Kerion Celsi

0 Actively Recruiting

Candidiasis, Vulvovaginal

0 Actively Recruiting

Tinea Cruris

0 Actively Recruiting

Tinea

0 Actively Recruiting

Intertrigo

0 Actively Recruiting

Oropharyngeal Candidiasis

0 Actively Recruiting

Ringworm

0 Actively Recruiting

Oravig Reviews: What are patients saying about Oravig?

4

Patient Review

6/16/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

I've had to deal with a lot of fungal infections due to my inhalers, and I've tried nystatin and dyflucan multiple times. They just don't work for me. This pill is expensive, but it does the job. It takes some time getting used to, but I feel that it's worth the price if it works.

2.7

Patient Review

11/16/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

I've only been using this pill for a few days, so it's hard to judge its effectiveness yet. It's not too comfortable having it in my upper lip, but I'm getting used to it. It's also pretty pricey if you don't have insurance.

1.3

Patient Review

9/15/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

This treatment was really bad for me. I had terrible dry mouth and started seeing hair in front of my eyes. I was so tired and exhausted all the time. I quit immediately and threw the bottle away. There has to be some other drug that will kill thrush. Fluconozole hasn't touched it after 6 rounds. :(

1

Patient Review

1/12/2011

Oravig for Candidiasis Fungal Infection of the Oropharynx

I really didn't enjoy the sensation of something in my mouth for such a long period of time. It was difficult to keep in place and seemed to get bigger as time went on. I would not use this product again or recommend it to anyone else.

1

Patient Review

1/30/2013

Oravig for Candidiasis Fungal Infection of the Oropharynx

I'm on my second 14-day supply of this drug and it still hasn't cleared up my thrush. Not to mention, it's extremely expensive. I wouldn't recommend this to anyone.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about oravig

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is oravig available?

"Although there are no therapeutically equivalent versions of Oravig currently available in the United States, it's important to be aware that there are online pharmacies which may attempt to sell illegal generic versions of the medication. These medications may be counterfeit and could potentially be unsafe."

Answered by AI

How do you take oravig?

"To use the Oravig buccal tablet, place the rounded side of the tablet against your gum and close your mouth. Press your finger gently against the side of your cheek for 30 seconds to make sure the tablet stays in place. Do not chew or swallow the tablet. Leave it in place until the next morning."

Answered by AI

What is oravig used for?

"Oral thrush is a condition that can be treated using Oravig (miconazole), an antifungal tablet that is dissolved in the patient's cheek. Oravig works by killing the fungus that causes yeast infections, by damaging its protective outer layer."

Answered by AI

What class of medication is oravig?

"Oravig is a prescription medication used to treat symptoms of Oropharyngeal Candidiasis. Oravig may be used alone or in combination with other medications. Oravig belongs to a class of drugs called "Antifungals, Other.""

Answered by AI

Clinical Trials for Oravig

Image of Montana State University in Bozeman, United States.

Treatment for Resistance Training

18 - 35
All Sexes
Bozeman, MT

The purpose of this clinical trial is to determine how certain food items affect oxidative stress, inflammation, and performance recovery from exercise induced muscle damage in a resistance trained population. The main questions we aim to answer are the following: * Do Haskaps speed the recovery of oxidative stress and inflammation markers after an intense lower body workout in resistance trained adults? * Do Haskaps speed the recovery of performance measures after an intense lower body workout in resistance trained adults? * The data collected in this investigation may also be used to ask additional questions not yet identified. For example, we may use the stored samples to evaluate how the blood metabolites of participants differ before and after intense exercise. These additional questions are called secondary analyses. Please note that no genetic analysis will be conducted and racial and ethnic differences among participants will not be used in any secondary analyses. Researches will compare Haskap juice to a color, flavor and carbohydrate matched placebo to see if Haskaps speed recovery in inflammation, oxidative stress and performance. * Participants will be asked to drink either Haskap juice or placebo and follow a low polyphenolic diet * Participants will perform an intense resistance workout * Participants will have their blood drawn before and after the workout * Performance will be analyzed at 24, 48 and 72 hours after the workout

Recruiting
Paid Trial

Montana State University

Mary P Miles

Image of University of New Brunswick in Fredericton, Canada.

Mediterranean Diet for Toddler Health

24 - 36
All Sexes
Fredericton, Canada

Toddlerhood (ages 2-3) is a critical window when the gut microbiome is still developing and eating habits are being established. Yet, many Canadian toddlers eat diets high in sugar and salt, which may affect long-term health. This study will test whether a MED diet can improve dietary inflammation, gut health, and body composition in toddlers and whether a tailored nutrition education program for parents can help families maintain healthy eating patterns. In this study, toddlers will be randomly assigned to a 3-week MED diet or their usual diet. Families in the MED diet group will receive free meal boxes for the 3 weeks, plus guidance from a nutrition researcher through a structured education program. The standard diet group will continue their regular diet with general nutrition advice. Researchers will collect dietary information, body composition assessments, and stool samples to measure gut microbiome composition and metabolites. This first study of a controlled diet intervention in toddlers, combining behavioral support, high-quality food provision, and advanced gut microbiome analysis, will help understand how early diet shapes lifelong eating habits and health, guiding public health strategies and precision nutrition approaches to prevent chronic disease from early life.

Waitlist Available
Has No Placebo

University of New Brunswick

Dr. Maryam Kebbe, PhD, CLC

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Image of Department of Nutritional Sciences in Storrs, United States.

Freeze-dried Grape Powder for Healthy Aging

50 - 75
All Sexes
Storrs, CT

The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, and metabolism that are known to change with aging. Grapes contain several nutrients and antioxidant polyphenols such as resveratrol, quercetin, vitamin K and fiber, which are known to promote heart and immune health. However, the effects of grapes on altering immune profiles within the context of aging is not well understood. Therefore, this study will explore how daily grape consumption impacts certain markers of immunity in healthy middle- and older-aged adults. The main study procedures include consumption of a freeze-dried grape powder and control powder (which tastes the same but has none of the grape compounds that are being studied) mixed with water as a beverage on a daily basis for 4 weeks each. The investigators will additionally ask that participants avoid eating grapes and certain other antioxidant/grape-related foods and beverages throughout the 13-week study. Participants will additionally be asked to complete surveys about their diet, physical activity, and medical history, as well as provide blood samples and body weight measures throughout the course of the study. Participation in the study is expected to last about 6.25 hours over the course of 13 weeks and will include 7 visits.

Recruiting
Paid Trial

Department of Nutritional Sciences

Image of Abcentra Investigational Site in Los Angeles, United States.

Orticumab for Heart Attack

18+
All Sexes
Los Angeles, CA

The goal of this clinical trial is to determine the clinical effect of orticumab treatment on inflammation in study participants with prior myocardial infarction who have elevated coronary inflammation based on CCTA. The main question it aims to answer is: Clinical effects of orticumab treatment on inflammation of the coronary artery parameters measured with CCTA Researchers will compare the effects with placebo group after 6 months of treatment Participants will Keep the planned study visit appointments Provide complete information about medical and medical history Speak to the study doctor before changing any of non-study treatments, including starting new medications, receiving any vaccinations, or setting out to join any other clinical studies

Phase 2
Recruiting

Abcentra Investigational Site (+6 Sites)

Abcentra

Image of School of Public Health in Bloomington, United States.

High Salt Intake for High Blood Pressure

60 - 85
All Sexes
Bloomington, IN

Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. Salt is particularly deleterious in older adults who are more likely to exhibit salt-sensitive hypertension. However, salt consumption remains high in the United States. Thus, there is a critical need for strategies to counteract the effects of high dietary salt as consumption is likely not going to decrease. One promising option is ketones, metabolites that are produced in the liver during prolonged exercise and very low-calorie diets. While exercise and low-calorie diets are beneficial, not many people engage in these activities. Limited evidence indicates that ketone supplements improve cardiovascular health in humans. Additionally, published rodent data indicates that ketone supplements prevent high salt-induced increases in blood pressure, blood vessel dysfunction, and kidney injury. Our human pilot data also indicates that high dietary salt reduces intrinsic ketone production, but it is unclear whether ketone supplementation confers humans' protection against high salt similar to rodents. Therefore, the investigators seek to conduct a short-term high-dietary salt study to determine whether ketone supplementation prevents high dietary salt from eliciting increased blood pressure, blood vessel dysfunction, and kidney injury/impaired blood flow. The investigators will also measure inflammatory markers in blood samples and isolate immune cells that control inflammation. Lastly, the investigators will also measure blood ketone concentration and other circulating metabolites that may be altered by high salt, which could facilitate novel therapeutic targets to combat high salt.

Recruiting
Has No Placebo

School of Public Health

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Image of Goldring Center for High Performance Sport in Toronto, Canada.

Physical Activity for Delayed Onset Muscle Soreness

18 - 35
All Sexes
Toronto, Canada

After completing novel activity or exercise we may experience exercise-induced muscle damage (EIMD), resulting in a period of reduced muscle function and delayed onset muscle soreness (DOMS). DOMS is characterized by muscle pain and tenderness that typically resolves within a week. While the precise cause of DOMS is unknown, there is growing evidence implicating damage to the connective tissue that surrounds our muscle fibers and is related to a small amount of inflammation. This inflammation is a normal part of our body's ability to recovery from injuries and may be visualized through the use of ultrasound technology. A variety of recovery techniques have been proposed that may help with the recovery of DOMS such as massage and electrical muscle stimulation, but these are not always accessible. Therefore, we are interested in investigating whether the number of daily steps can affect how you experience DOMS.

Waitlist Available
Has No Placebo

Goldring Center for High Performance Sport

Image of UCSF in San Francisco, United States.

Moisturizers for Aging

65+
All Sexes
San Francisco, CA

This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with moisturizers can reduce serum biomarkers of inflammation. The primary objective is to determine the feasibility for a larger trial, and the secondary objectives are to determine the extent to which measures of serum inflammation, skin barrier function, and the skin microbiome change in response to moisturizers. Participants will be asked to apply one of two topical moisturizers that are widely available over the counter in the US (Vaseline® 100% pure petroleum jelly or CeraVe® moisturizing cream) once daily for 4 weeks to the front of the torso, buttocks, arms, and legs. Subjects will act as their own control (i.e. they will be asked to apply the study moisturizer they are randomized to for one intervention period (4 weeks) and not to apply topical moisturizers for the other 4- week intervention period). Participants will be randomized in a 1:1:1:1 ratio to one of 4 treatment groups: i. no intervention then CeraVe; ii. CeraVe then no intervention; iii. no intervention then Vaseline; iv. Vaseline then no intervention. At each visit (baseline, week 4, and week 8), participants will undergo skin barrier testing, skin microbiome sampling, and phlebotomy to measure serum inflammatory markers.

Phase 4
Recruiting

UCSF

Katrina Abuabara, MD

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