Bactroban

Impetigo, Communicable Diseases, staphylococcus aurea colonization of the nasal passage + 3 more

Treatment

7 FDA approvals

0 Active Studies for Bactroban

What is Bactroban

Mupirocin

The Generic name of this drug

Treatment Summary

Mupirocin is an antibiotic medication derived from the bacteria _Pseudomonas fluorescens_. It works by inhibiting bacterial protein synthesis and does not cause cross-resistance with other antibiotics. It is only available as a topical cream or ointment and is used to treat skin infections caused by _Staphylococcus aureus_ and _Streptococcus pyogenes_. It may also be used to eradicate nasal carriage of staphylococci when administered intranasally. It is marketed under the brand name Bactroban.

Bactroban

is the brand name

image of different drug pills on a surface

Bactroban Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bactroban

Mupirocin

1996

98

Approved as Treatment by the FDA

Mupirocin, also called Bactroban, is approved by the FDA for 7 uses which include staphylococcus aurea colonization of the nasal passage and Secondary infection Skin infection .

staphylococcus aurea colonization of the nasal passage

Secondary infection Skin infection

Bacterial infection due to streptococcus, group A

Impetigo

Bacterial Infections

Impetigo

Communicable Diseases

Effectiveness

How Bactroban Affects Patients

Mupirocin can kill certain types of bacteria, including Staphylococcus aureus and Streptococcus pyogenes. It works by blocking the formation of proteins the bacteria need to survive. Generally, it takes a higher concentration of mupirocin to kill the bacteria than to stop its growth. Studies have shown that mupirocin is effective in treating impetigo and other skin infections in over 90% of patients. In some cases, bacteria can become resistant to mupirocin if they create a modified protein or get a gene from another bacteria that makes them resistant.

How Bactroban works in the body

Mupirocin works by binding to an enzyme that helps convert isoleucine and tRNA into a tRNA molecule. By blocking this enzyme, mupirocin stops bacteria from making proteins and RNA. It works quickly, killing 90-99% of bacteria after 24 hours.

When to interrupt dosage

The proposed quantity of Bactroban is contingent upon the determined disorder, including Communicable Diseases, Bacterial Infections and staphylococcus aurea colonization of the nasal passageway. The amount likewise fluctuates as per the technique of delivery (e.g. Ointment or Cream) featured in the table beneath.

Condition

Dosage

Administration

staphylococcus aurea colonization of the nasal passage

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Impetigo

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Impetigo

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Communicable Diseases

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Impetigo

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Bacterial Infections

0.02 mg/mg, , 0.0215 mg/mg, 2.0 %

, Topical, Ointment - Topical, Cream, Cream - Topical, Ointment, Nasal, Ointment - Nasal, Kit - Topical, Kit

Warnings

Bactroban Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Mupirocin may interact with Pulse Frequency

There are 16 known major drug interactions with Bactroban.

Common Bactroban Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Mupirocin.

(R)-warfarin

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with (R)-warfarin.

(S)-Warfarin

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with (S)-Warfarin.

4-hydroxycoumarin

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with 4-hydroxycoumarin.

Acenocoumarol

Moderate

The risk or severity of bleeding can be increased when Mupirocin is combined with Acenocoumarol.

Bactroban Toxicity & Overdose Risk

Taking too much mupirocin can be toxic, with an oral LD50 in rats of 5000 mg/kg. No tests have been done to see if mupirocin causes cancer. Mupirocin has not been found to cause mutation in animals or bacteria. When given to rats, no signs of fertility problems were noticed. Mupirocin has been found in breast milk, so pregnant women should be cautious when using it. However, studies have found that it is safe and effective for children aged 2 months to 16 years.

image of a doctor in a lab doing drug, clinical research

Bactroban Novel Uses: Which Conditions Have a Clinical Trial Featuring Bactroban?

One active trial is investigating the use of Bactroban to combat Bacterial Infections, Impetigo and Communicable Diseases.

Condition

Clinical Trials

Trial Phases

Bacterial Infections

0 Actively Recruiting

staphylococcus aurea colonization of the nasal passage

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Impetigo

0 Actively Recruiting

Impetigo

0 Actively Recruiting

Impetigo

0 Actively Recruiting

Bactroban Reviews: What are patients saying about Bactroban?

5

Patient Review

8/8/2012

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

Within three days of using Bactroban Ointment, the sores in my right nostril had completely vanished. I couldn't be happier with how this medication worked and relieved me of a lot of pain.

5

Patient Review

3/7/2013

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

I've only been using this product for a day, so I can't speak to its long-term efficacy yet. That said, it seems to be helping my folliculitis (which was red, irritated, and had pus-filled pimples) clear up.

5

Patient Review

5/20/2018

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

I went to the ER and was diagnosed with impetigo. The doctor prescribed bactroban, but it made the itching so much worse without actually helping the infection.

5

Patient Review

7/23/2012

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

The only issue I had with this treatment was how often I needed to apply it. Otherwise, it was great!

5

Patient Review

11/25/2010

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

4

Patient Review

5/11/2012

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

My daughter started getting rashes around her mouth when she was two years old. The doctor prescribed this medication, and it worked the very next day! I now have a cold sore on my lip, so I'm using the same medication to see if it really works on cold sores.

3

Patient Review

10/20/2010

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

2.3

Patient Review

8/24/2016

Bactroban for Infection of the Skin caused by Staphylococcus Aureus

My doctor prescribed this for a wound on my foot that wouldn't heal, but after just five days of using it I had to take time off work because it severely burned my feet. Will never use again.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about bactroban

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I get BACTROBAN over the counter?

"There will be no over-the-counter equivalent to Bactroban. Bactroban contains the antibiotic mupirocin."

Answered by AI

What is BACTROBAN cream 2% used for?

"This ointment is used to treat skin infections such as impetigo, folliculitis, and furunculosis. Apply it to the affected area two to three times a day for up to ten days, depending on how your body responds to the treatment."

Answered by AI

What is BACTROBAN used to treat?

"The ointment can be used to treat impetigo, hair root infections, and boils. It can also be used on skin that has been damaged by eczema, dermatitis, psoriasis, herpes, wounds, cuts, grazes, insect bites, and minor burns."

Answered by AI

Do you need a prescription for BACTROBAN?

"Mupirocin ointment is used to treat impetigo, a skin infection caused by bacteria. The ointment kills bacteria or prevents their growth. It is available only with a doctor's prescription."

Answered by AI