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What is Bactroban
MupirocinThe Generic name of this drug
Treatment SummaryMupirocin is an antibiotic medication derived from the bacteria _Pseudomonas fluorescens_. It works by inhibiting bacterial protein synthesis and does not cause cross-resistance with other antibiotics. It is only available as a topical cream or ointment and is used to treat skin infections caused by _Staphylococcus aureus_ and _Streptococcus pyogenes_. It may also be used to eradicate nasal carriage of staphylococci when administered intranasally. It is marketed under the brand name Bactroban.
Bactrobanis the brand name
Bactroban Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bactroban
Mupirocin
1996
98
Approved as Treatment by the FDA
Mupirocin, also called Bactroban, is approved by the FDA for 4 uses which include staphylococcus aurea colonization of the nasal passage and Impetigo .staphylococcus aurea colonization of the nasal passage
Impetigo
Communicable Diseases
Bacterial Infections
Effectiveness
How Bactroban Affects PatientsMupirocin can kill certain types of bacteria, including Staphylococcus aureus and Streptococcus pyogenes. It works by blocking the formation of proteins the bacteria need to survive. Generally, it takes a higher concentration of mupirocin to kill the bacteria than to stop its growth. Studies have shown that mupirocin is effective in treating impetigo and other skin infections in over 90% of patients. In some cases, bacteria can become resistant to mupirocin if they create a modified protein or get a gene from another bacteria that makes them resistant.
How Bactroban works in the bodyMupirocin works by binding to an enzyme that helps convert isoleucine and tRNA into a tRNA molecule. By blocking this enzyme, mupirocin stops bacteria from making proteins and RNA. It works quickly, killing 90-99% of bacteria after 24 hours.
When to interrupt dosage
The proposed quantity of Bactroban is contingent upon the determined disorder, including Communicable Diseases, Bacterial Infections and staphylococcus aurea colonization of the nasal passageway. The amount likewise fluctuates as per the technique of delivery (e.g. Ointment or Cream) featured in the table beneath.Condition
Dosage
Administration
staphylococcus aurea colonization of the nasal passage
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Impetigo
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Impetigo
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Bacterial Infections
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Communicable Diseases
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Impetigo
0.02 mg/mg, , 0.0215 mg/mg, 2.0 %
, Topical, Ointment, Ointment - Topical, Cream, Cream - Topical, Ointment - Nasal, Nasal, Kit, Kit - Topical
Warnings
Bactroban ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Mupirocin may interact with Pulse Frequency
Common Bactroban Drug Interactions
Drug Name
Risk Level
Description
Vibrio cholerae CVD 103-HgR strain live antigen
Major
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Mupirocin.
(R)-warfarin
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with (R)-warfarin.
(S)-Warfarin
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with (S)-Warfarin.
4-hydroxycoumarin
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with 4-hydroxycoumarin.
Acenocoumarol
Moderate
The risk or severity of bleeding can be increased when Mupirocin is combined with Acenocoumarol.
Bactroban Toxicity & Overdose RiskTaking too much mupirocin can be toxic, with an oral LD50 in rats of 5000 mg/kg. No tests have been done to see if mupirocin causes cancer. Mupirocin has not been found to cause mutation in animals or bacteria. When given to rats, no signs of fertility problems were noticed. Mupirocin has been found in breast milk, so pregnant women should be cautious when using it. However, studies have found that it is safe and effective for children aged 2 months to 16 years.
Bactroban Novel Uses: Which Conditions Have a Clinical Trial Featuring Bactroban?
One active trial is investigating the use of Bactroban to combat Bacterial Infections, Impetigo and Communicable Diseases.Condition
Clinical Trials
Trial Phases
Impetigo
0 Actively Recruiting
Impetigo
0 Actively Recruiting
Communicable Diseases
0 Actively Recruiting
Bacterial Infections
0 Actively Recruiting
Impetigo
0 Actively Recruiting
staphylococcus aurea colonization of the nasal passage
0 Actively Recruiting
Bactroban Reviews: What are patients saying about Bactroban?
5Patient Review
8/8/2012 Within three days of using Bactroban Ointment, the sores in my right nostril had completely vanished. I couldn't be happier with how this medication worked and relieved me of a lot of pain.
5Patient Review
3/7/2013 I've only been using this product for a day, so I can't speak to its long-term efficacy yet. That said, it seems to be helping my folliculitis (which was red, irritated, and had pus-filled pimples) clear up.
5Patient Review
5/20/2018 I went to the ER and was diagnosed with impetigo. The doctor prescribed bactroban, but it made the itching so much worse without actually helping the infection.
5Patient Review
7/23/2012 The only issue I had with this treatment was how often I needed to apply it. Otherwise, it was great!
5Patient Review
11/25/20104Patient Review
5/11/2012 My daughter started getting rashes around her mouth when she was two years old. The doctor prescribed this medication, and it worked the very next day! I now have a cold sore on my lip, so I'm using the same medication to see if it really works on cold sores.
3Patient Review
10/20/20102.3Patient Review
8/24/2016 My doctor prescribed this for a wound on my foot that wouldn't heal, but after just five days of using it I had to take time off work because it severely burned my feet. Will never use again.
Patient Q&A Section about bactroban
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can I get BACTROBAN over the counter?
"There will be no over-the-counter equivalent to Bactroban. Bactroban contains the antibiotic mupirocin."
Answered by AI
What is BACTROBAN cream 2% used for?
"This ointment is used to treat skin infections such as impetigo, folliculitis, and furunculosis. Apply it to the affected area two to three times a day for up to ten days, depending on how your body responds to the treatment."
Answered by AI
Do you need a prescription for BACTROBAN?
"Mupirocin ointment is used to treat impetigo, a skin infection caused by bacteria. The ointment kills bacteria or prevents their growth. It is available only with a doctor's prescription."
Answered by AI